COX-2 expressed with insulin in pancreatic beta-cells, and in the infiltrated leukocytes in inflamed islets of diabetic mice

European Journal of Inflammation

Volumn 3, Issue 2, 2005, Pages 55-61

  Luo, Cheng ^a,b   Simell, O ^a   Kung, H F ^c   He, M L ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

COX 2; Infiltrates; Insulin; Nonobese diabetic (NOD) mouse; Type 1 diabetes (T1D)

Indexed keywords

ARACHIDONIC ACID; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INSULIN; PLACEBO;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL INFILTRATION; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DIABETOGENESIS; DISEASE COURSE; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; INJECTION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULITIS; INTESTINE; LEUKOCYTE; LYMPHOCYTE MIGRATION; MACROPHAGE; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; SCID MOUSE;

EID: 23244432491     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727X0500300202     Document Type: Article

References (23)

1. Roep B.O. 2003. The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia 46:305.
2. Prochazka M., H.R. Gaskins, L.D. Shultz and E.H. Leiter. 1992. The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. Proc. Natl. Acad. Sci. 89:3290.
3. Shultz L.D., P.A. Schweitzer, S.W. Christianson, et al. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154:180.
4. Luo C., L. Strauss, A. Ristimaki, T. Streng and R. Santi. 2001. Constant expression of cyclooxygenase-2 gene in prostate and the lower urinary tract of estrogen-treated male rats. Z. Naturforsch. 56:455.
5. Tucker O.N., A.J. Dannenberg, E.K. Yang, et al. 1999. Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res. 59:987.
6. Molina M.A., M. Sitja-Arnau, M.G. Lemoine, M.L. Frazier and F.A. Sinicrope. 1999. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 59:4356.
7. Luo C., M. Kallajoki, R. Gross, M. Mulari, T. Teros, L. Ylinen, M. Makinen, J. Laine and O. Simell. 2002. Cellular distribution and contribution of cyclooxygenase COX-2 to diabetogenesis in NOD mouse. Cell Tissue Res. 310:169.
8. Litherland S.A., X.T. Xie, A.D. Hutson, et al. 1999. Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. J. Clin. Invest. 104:515.
9. Corbett J.A. and M.L. McDaniel. 1994. Reversibility of interleukin-1 beta-induced islet destruction and dysfunction by the inhibition of nitric oxide synthase. Biochem. J. 299:719.
10. Carpinelli A.R., M.C. Picinato, E. Stevanato, H.R. Oliveira and R. Curi. 2002. Insulin secretion induced by palmitate, a process fully dependent on glucose concentration. Diabetes Metab. 28(3S):37.
11. Tran P.O., C.E. Gleason and R.P. Robertson. 2002. Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes 51:1772.
12. Ganapathy V., T. Gurlo, H.O. Jarstadmarken and H. Grafenstein. 2000. Regulation of TCR-induced IFN-gamma release from islet-reactive non-obese diabetic CD8(+) T cells by prostaglandin E2 receptor signaling. Int. Immunol. 12:851.
13. Tetsuka T., D. Daphna-Iken, S.K. Srivastava, L.D. Baier, J. DuMaine and A.R. Morrison. 1994. Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc. Natl. Acad. Sci. 91:12168.
14. Luo C., V.J. Laine, L. Ylinen, T. Teros, M. Makinen, A. Ristimaki and O. Simell. 2002. Expression of cyclooxygenase-2 in intestinal goblet cells of pre-diabetic NOD mice. Acta Physiol. Scand. 174:265.
15. Iniguez M.A., C. Punzon and M. Fresno. 1999. Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors. J. Immunol. 163:111.
16. Kim H.J. and T.Y. Kim. 2004. IGF-II-Mediated COX-2 gene gxpression in human keratinocytes through extracellular signal-regulated kinase pathway. J. Invest. Dermatol. 123:547.
17. Kukreja A. and N.K. Maclaren. 1999. Autoimmunity and diabetes. J. Clin. Endocrinol. Metab. 84:4371.
18. Newberry R., W.F. Stenson and R.G. Lorenz. 1999. Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat. Med. 5:900.
19. Slover R.H. and G.S. Eisenbarth. 1997. Prevention of type 1 diabetes and recurrent β-cell destruction of transplanted islets. Endocrine Reviews 18:241.
20. Gough P.J. and S. Gordon. 2000. The role of scavenger receptors in the innate immune system. Microbes Infect. 2:305.
21. Svensson L., G.Camejo, A. Cabre, J.C. Vallve, J. Pedreno, K. Noren, O. Wiklund and L.M. Hulten. 2003 Fatty acids modulate the effect of darglitazone on macrophage CD36 expression. Eur. J. Clin. Invest. 33:464.
22. Tabatabaie T., A.M. Waldon, J.M. Jacob, R.A. Floyd and Y. Kotake. 2000. COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice. Biochem. Biophys. Res. Commun. 273:699.
23. Heitmeier M.R., C.B. Kelly, N.J. Ensor, K.A. Gibson, K.G. Mullis, J.A. Corbett and T.J. Maziasz. 2004. Role of cyclooxygenase-2 in cytokine-induced beta -cell dysfunction and damage by isolated rat and human islets. J. Biol. Chem. 279:53145.