Cellular distribution and contribution of cyclooxygenase “COX”-2 to diabetogenesis in NOD mouse

Cell and Tissue Research

Volumn 310, Issue 2, 2002, Pages 169-175

  Luo, Cheng ^a,b   Kallajoki, Markku ^a   Gross, Rene ^c   Mulari, Mika ^a   Teros, Tamara ^a,b   Ylinen, Laura ^a,b   Makinen, Marjaana ^a,b   Laine, Jukka ^a   Simell, Olli ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c CNRS   (France)

Author keywords

Confocal microscopy; COX 2; INS 1 cells; Macrophage; Mouse BALB c ; Non obese diabetic NOD mouse

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; GLUCOSE; INSULIN; PROSTAGLANDIN E;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; FEMALE; FLUORESCENCE MICROSCOPY; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULITIS; INTRACELLULAR SPACE; MACROPHAGE; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; CELL COMPARTMENTATION; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; ISOENZYMES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; PANCREAS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES;

ANIMALIA; MAMMALIA;

EID: 12244305551     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-002-0628-6     Document Type: Article

References (20)

1. Beffy P, Lajoix AD, Masiello P, Dietz S, Peraldi-Roux S, Chardes T, Ribes G, Gross R “2001” A constitutive nitric oxide synthase modulates insulin secretion in the INS-1 cell line. Mol Cell Endocrinol 183:41-48
2. Fox CJ, Danska JS “1998” Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation. Diabetes 47:331-338
3. Ganapathy V, Gurlo T, Jarstadmarken HO, von Grafenstein H “2000” Regulation of TCR-induced IFN-gamma release from islet-reactive non-obese diabetic CD8“+” T cells by prostag-landin E“2” receptor signaling. Int Immunol 12:851-860
4. Guan Z, Buckman SY, Baier LD, Morrison AR “1998” IGF-I and insulin amplify IL-1 beta-induced nitric oxide and prostaglandin biosynthesis. Am J Physiol 274:F673-F679
5. Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL “1995” Suppression of insulitis in non-obese diabetic “NOD” mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol 147:1193-1199
6. Hilkens CM, Vermeulen H, van Neerven RJ, Snijdewint FG, Wierenga EA, Kapsenberg ML “1995” Differential modulation of T helper type 1 “Th1” and T helper type 2 “Th2” cytokine secretion by prostaglandin E2 critically depends on interleu-kin-2. Eur J Immunol 25:59-63
7. Hla T, Neilson K “1992” Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A 89:7384-738
8. Lee KU, Amano K, Yoon JW “1988” Evidence for initial involvement of macrophage in development of insulitis in NOD mice. Diabetes 37:989-991
9. Litherland SA, Xie XT, Hutson AD, Wasserfall C, Whittaker DS, She JX, Hofig A, Dennis MA, Fuller K, Cook R, Schatz D, Moldawer LL, Clare-Salzler MJ “1999” Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. J Clin Invest 104:515-523
10. Luo C, Strauss L, Ristimaki A, Streng T, Santti R “2001” Constant expression of cyclooxygenase-2 gene in prostate and the lower urinary tract of estrogen-treated male rats. Z Naturforsch [C] 56:455-463
11. Luo C, Laine JVO, Ylinen L, Teros T, Makinen M, Ristimaki A, Simell O “2002” Expression of cyclooxygenase-2 in intestinal goblet cells of prediabetic NOD mice. Acta Physiol Scand 174:265-274
12. Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML, Sinicrope FA “1999” Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res 59:4356-4362
13. Palmen T, Ahola H, Palgi J, Aaltonen P, Luimula P, Wang S, Jaakkola I, Knip M, Otonkoski T, Holthofer H “2001” Nephrin is expressed in the pancreatic beta cells. Diabetologia 44:1274-1280
14. Ristimaki A, Honkanen N, Jankala H, Sipponen P, Harkonen M “1997” Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res 57:1276-1280
15. Robertson RP “1998” Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis. Diabetes 47:1379-1383
16. Smith WL, Dewitt DL “1996” Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 62:167-215
17. Sorli CH, Zhang HJ, Armstrong MB, Rajotte RV, Maclouf J, Robertson RP “1998” Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. Proc Natl Acad Sci U S A 95:1788-1793
18. Takano M, Nishimura H, Kimura Y, Washizu J, Mokuno Y, Nimura Y, Yoshikai Y “1998” Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice. J Immunol 161:3019-3025
19. Tran PO, Gleason CE, Poitout V, Robertson RP “1999” Prostaglandin E“2” mediates inhibition of insulin secretion by interleukin-1beta. J Biol Chem 274:31245-31248
20. Walker DA, Dillon M, Levitt G, Cervera A, Shaw D, Pritchard J “1992” Multiple exostosis “osteochondroma” and Wilms' tumour, a possible association. Med Pediatr Oncol 20:360-361