Coprecipitation of nonoxynol-9 with polyvinylpyrrolidone to decrease vaginal irritation potential while maintaining spermicidal potency

AAPS PharmSciTech

Volumn 4, Issue 3, 2003, Pages

  Fowler, Philip T ^a   Doncel, Gustavo F ^b   Bummer, Paul M ^a   Digenis, George A ^a  

^a University of Kentucky   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

Hemolysis; HIV; Micelle; Red blood cell assay; Sander Cramer assay

Indexed keywords

NONOXINOL 9; ORGANIC SOLVENT; POVIDONE; SPERMICIDAL AGENT; IRRITANT AGENT; NONOXINOL; PHARMACEUTICAL VEHICLES AND ADDITIVES;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG POTENCY; DRUG STRUCTURE; FREEZE DRYING; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MATHEMATICAL COMPUTING; MICELLE; NONHUMAN; PRECIPITATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; VAGINA DISEASE; VAGINA EPITHELIUM; ANIMAL; BIOASSAY; CHEMISTRY; DOG; DRUG ANTAGONISM; DRUG EFFECT; ERYTHROCYTE; FEMALE; METABOLISM; SPERMATOZOON; VAGINITIS;

ANIMALS; BIOLOGICAL ASSAY; DOGS; ERYTHROCYTES; FEMALE; HEMOLYSIS; HUMANS; IRRITANTS; MALE; MICELLES; NONOXYNOL; PHARMACEUTIC AIDS; POVIDONE; PRECIPITATION; SPERMATOCIDAL AGENTS; SPERMATOZOA; VAGINITIS;

EID: 23144464358     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt040330     Document Type: Article

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