Beauty and the beast. The nitric oxide paradox in systemic sclerosis

Rheumatology

Volumn 41, Issue 8, 2002, Pages 843-847

  Matucci Cerinic, M ^a,c   Kahaleh, M B ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b MEDICAL COLLEGE OF OHIO   (United States)

^c Division of Rheumatology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; CELL ADHESION MOLECULE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; BLOOD VESSEL WALL; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; DISEASE ACTIVITY; EDITORIAL; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME POLYMORPHISM; HUMAN; IMMUNE INJURY; INFLAMMATION; ISCHEMIA; MICROVASCULATURE; MOUSE; NONHUMAN; OXIDATION; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAYNAUD PHENOMENON; REPERFUSION INJURY; SKIN DEFECT; SMOOTH MUSCLE FIBER; SYSTEMIC SCLEROSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION INHIBITION; VASCULAR ENDOTHELIUM; VASOSPASM;

ENDOTHELIUM, VASCULAR; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SCLERODERMA, SYSTEMIC;

EID: 0036053611     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (43)

1. Autoimmunity and vascular involvement in systemic sclerosis (SSc)
2. The vascular involvement in systemic sclerosis
3. New approaches to Raynaud's phenomenon
4. Endothelin an endothelial dependent vasoconstrictor in scleroderma. Enhanced production and profibrotic action
5. Serum from patients with Raynaud's phenomenon inhibits prostacyclin production
6. Study of endothelial dependent relaxation in scleroderma
7. Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis
8. The effects of iloprost infusion on microcirculation is independent of nitric oxide metabolites and endothelin I in chronic peripheral ischemia
9. Correlation between nitric oxide production and markers of endothelial activation in systemic sclerosis: Findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule I, and vascular adhesion molecule I
10. Increased nitric oxide production in patients with systemic sclerosis
11. Biosynthesis and metabolism of endothelium-derived nitric oxide
12. Endothelium derived nitric oxide: Actions and properties
13. Local venomotor response to intravenous infusion of substance P and glyceryl trinitrate in systemic sclerosis
14. The loss of endothelium dependent vascular tone control in systemic sclerosis
15. Defective endothelially mediated pulmonary vasodilation in systemic sclerosis
16. Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma
17. Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma
18. Down regulation of nitric oxide synthase gene in microvascular endothelial cells from lesional scleroderma: Assessment by quantitative RT-PCR and possible role for cytotoxic T cells
19. Exacerbation of antigen induced arthritis in inducible nitric oxide synthase deficient mice
20. The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis
21. Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes
22. Interactions between nitric oxide and lipid oxidation pathway: Implications for vascular disease
23. Protective effect of nitric oxide against iron induced neuronal damage
24. Nitric oxide down regulates MKP-3mRNA levels: Involvement in endothelial cell protection from apoptosis
25. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cells
26. From Raynaud's phenomenon to systemic sclerosis: Lack or exhaustion of adaptation?
27. Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin
28. N-acetyl cysteine reduces superoxide anion and peroxynitrite production of lung alveolar macrophages in systemic sclerosis
29. Increased production of nitric oxide stimulated by interleukin-1β in peripheral blood mononuclear cells in patients with systemic sclerosis
30. Nitric oxide synthesis in peripheral blood monocytes and polymorphonuclear cells from patients with systemic sclerosis
31. Role of peroxynitrite and activation of poly(ADP-ribose) synthase in the vascular failure induced by zymosan-activated plasma
32. Endothelial cell apoptosis in systemic sclerosis induced by antibody-dependent cell-mediated cytotoxicity via CD95
33. Peroxynitrite induces haem-1 oxygenase-1 in vascular endothelial cells: A link to apoptosis
34. Nitric oxide induces and inhibits apoptosis through different pathways
35. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein e-knockout mice
36. TGF-beta 1 protects hippocampal neurons against degeneration caused by transient global ischemia. Dose dependent relationship and potential neuroprotective mechanisms
37. Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension
38. Increased nitric oxide in exhaled air in patients with systemic sclerosis
39. Exhaled nitric oxide is increased in active fibrosing alveolitis
40. Exhaled nitric oxide in systemic sclerosis: Relationships with lung involvement and pulmonary hypertension
41. Exhaled nitric oxide is elevated in patients with progressive systemic sclerosis without interstitial lung disease
42. High prevalence of polymorphisms of angiotensin-converting enzyme (I/D) and endothelial nitric oxide synthase (Glu298Asp) in patients with systemic sclerosis
43. Low levels of nitric oxide (NO) in systemic sclerosis: Inducible NO synthase production is decreased in cultured peripheral blood monocyte/macrophage cells