Improving treatment of depression in the elderly: Two innovations in statistical design of clinical trials

Journal of Clinical Psychopharmacology

Volumn 25, Issue 4 SUPPL. 1, 2005, Pages

  Lavori, Philip W ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT;

CLINICAL TRIAL; COMORBIDITY; CONFERENCE PAPER; DEPRESSION; DRUG MARKETING; GERONTOPSYCHIATRY; HUMAN; METHODOLOGY; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; RELAPSE; REMISSION; SAMPLING; STATISTICAL ANALYSIS; TREATMENT FAILURE; TREATMENT OUTCOME;

AGED; ANTIDEPRESSIVE AGENTS; CLINICAL TRIALS; DEPRESSIVE DISORDER; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); RESEARCH DESIGN;

EID: 23044494208     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jcp.0000168502.16361.ad     Document Type: Conference Paper

References (11)

1. Lavori PW, Rush AJ, Wisniewski SR, et al. Strengthening clinical effectiveness trials: equipoise-stratified randomization. Biol. Pychiatry. 2001;50:792-801.
2. Angell M. The pharmaceutical industry-to whom is it accountable? N Engl J Med. 2000;342:1902-1904.
3. Lavori PW, Wagner TH, Feussner JR. Ethics and economics in placebo-controlled trials of new drugs for mood disorders. TEN Trends Evidence-Based Neuropsychiatry. 2000;2:44-48.
4. Lavori PW, Dawson R. Designing for intent-to-treat. Drug Inf J. 2001; 35:1079-1086.
5. Rush AJ, Trivedi M, Fava M. Depression. IV: STAR*D treatment trial for depression. Am J Psychiatry. 2003;160:237.
6. Leon AC. Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments. J Clin Psychiatry. 2004;65:1511-1514.
7. Lavori PW, Dawson R, Rush AJ. Flexible treatment strategies in chronic disease: clinical and research implications. Biol Psychiatry. 2000;48: 605-614.
8. Stassen HH, Delini-Stula A, Angst J. Time course of improvement under antidepressant treatment: a survival-analytical approach. Eur Neuropsychopharmacol. 1993;3:127-135.
9. Lavori PW, Dawson R. A design for testing clinical strategies: biased adaptive within-subject randomization. J R Stat Soc. 2000;163:29-38.
10. Dawson R, Lavori PW. Placebo-free designs for evaluating new mental health treatments: the use of adaptive treatment strategies. Stat Med. 2004;23:3249-3262.
11. Boden WE, O'Rourke RA, Crawford MH, et al. Outcomes in patients with acute non-Q-wave myocardial infarction randomly assigned to an invasive as compared with a conservative management strategy. Veterans Affairs Non-Q-Wave Infarction Strategies in Hospital (VANQWISH) Trial Investigators. N Engl J Med. 1998;338:1785-1792.