Synthesis of a substance P antagonist: An efficient synthesis of 5-substituted-4-N,N-dimethylamino-1,2,3-triazoles

Organic Process Research and Development

Volumn 9, Issue 4, 2005, Pages 490-498

  Journet, Michel ^a   Cai, Dongwei ^a   Hughes, David L ^a   Kowal, Jason J ^a   Larsen, Robert D ^a,b   Reider, Paul J ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 23044492717     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050019s     Document Type: Article

References (38)

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35. 4) to 30/70 in 20 min. Retention time for azide was 7.35 min.
36. Triazole aldehyde 3 is highly water soluble. Its solubility is 63 g/L in methanol and DMSO, 19 g/L in DMF and <4 g/L in 2-propanol, 2-butanol, chloroform, THF, and toluene.
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38. 4 into a cold (0°C) solution of acetic acid (3.3 equiv) in DMAC will control the foaming caused by the release of hydrogen gas.