Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy

Diabetes Care

Volumn 28, Issue 8, 2005, Pages 1959-1964

  Granberg, Viktoria ^a,d   Ejskjaer, Niels ^b   Peakman, Mark ^c   Sundkvist, Göran ^a  

^a LUND UNIVERSITY   (Sweden)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d Malmo University Hospital   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ADOLESCENT; ADULT; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; AUTONOMIC NERVE; AUTONOMIC NEUROPATHY; BREATHING MECHANICS; COMPLEMENT FIXATION; COOLING; DISEASE ASSOCIATION; FEMALE; HEART RATE VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NERVE FUNCTION; PERIPHERAL NEUROPATHY; PROSPECTIVE STUDY; SYMPATHETIC GANGLION; VASOCONSTRICTION;

ADOLESCENT; ADULT; ALBUMINURIA; AUTOANTIBODIES; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 1; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; FOLLOW-UP STUDIES; HEART CONDUCTION SYSTEM; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; PERIPHERAL NERVES; TIME FACTORS;

EID: 23044463743     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.28.8.1959     Document Type: Article

References (36)

1. O'Brien IA, O'Hare JP, Lewin IG, Corrall RJ: The prevalence of autonomic neuropathy in insulin-dependent diabetes mellitus: a controlled study based on heart rate variability. Q J Med 61:957-967, 1986
2. Wheeler SG, Ahroni JH, Boyko EJ: Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes. Diabetes Res Clin Pract 58:131-138, 2002
3. Chen HS, Hwu CM, Kuo BI, Chiang SC, Kwok CF, Lee SH, Lee YS, Weih MJ, Hsiao LC, Lin SH, Ho LT: Abnormal cardiovascular reflex tests are predictors of mortality in type 2 diabetes mellitus. Diabet Med 18:268-273, 2001
4. O'Brien IA, McFadden JP, Corrall RJ: The influence of autonomic neuropathy on mortality in insulin-dependent diabetes. Q J Med 79:495-502, 1991
5. Maser RE, Mitchell BD, Vinik AI, Freeman R: The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care 26:1895-1901, 2003
6. Vinik AI, Freeman R, Erbas T: Diabetic autonomic neuropathy. Semin Neurol 23: 365-372, 2003
7. Sugimoto K, Murakawa Y, Sima AA: Diabetic neuropathy: a continuing enigma. Diabetes Metab Res Rev 16:408-433, 2000
8. Tesfaye S, Malik R, Ward JD: Vascular factors in diabetic neuropathy. Diabetologia 37:847-854, 1994
9. Duchen LW, Anjorin A, Watkins PJ, Mackay JD: Pathology of autonomic neuropathy in diabetes mellitus. Ann Intern Med 92:301-303, 1980
10. Gilbey SG, Guy RJ, Jones H, Vergani D, Watkins PJ: Diabetes and autonomic neuropathy: an immunological association? Diabet Med 3:241-245, 1986
11. Ejskjaer N, Arif S, Dodds W, Zanone MM, Vergani D, Watkins PJ, Peakman M: Prevalence of autoantibodies to autonomic nervous tissue structures in type 1 diabetes mellitus. Diabet Med 16:544-549, 1999
12. Muhr-Becker D, Ziegler AG, Druschky A, Wolfram G, Haslbeck M, Neundorfer B, Standl E, Schnell O: Evidence for specific autoimmunity against sympathetic and parasympathetic nervous tissues in type 1 diabetes mellitus and the relation to cardiac autonomic dysfunction. Diabet Med 15:467-472, 1998
13. Stroud CR, Heller SR, Ward JD, Hardisty CA, Weetman AP: Analysis of antibodies against components of the autonomic nervous system in diabetes mellitus. QJM 90:577-585, 1997
14. Rabinowe SL, Brown FM, Watts M, Smith AM: Complement-fixing antibodies to sympathetic and parasympathetic tissues in IDDM: autonomic brake index and heart-rate variation. Diabetes Care 13: 1084-1088, 1990
15. Sundkvist G, Lind P, Bergstrom B, Lilja B, Rabinowe SL: Autonomic nerve antibodies and autonomic nerve function in type 1 and type 2 diabetic patients. J Intern Med 229:505-510, 1991
16. Zanone MM, Favaro E, Catalfamo E, Quadri R, Sacchetti C, Cerutti F, Perin PC, Camussi G: Autonomic function and autoantibodies to autonomic nervous tissues at follow-up in a cohort of young patients with type 1 diabetes: effects of serum from diabetic patients on human adrenergic cells. J Neuroimmunol 139:66-75, 2003
17. Bergstrom B, Lilja B, Osterlin S, Sundkvist G: Autonomic neuropathy in type I diabetes: influence of duration and other diabetic complications. Acta Med Scand 222: 147-154, 1987
18. Nilsson H, Bergstrom B, Lilja B, Juul-Moller S, Carlsson J, Sundkvist G: Prospective study of autonomic nerve function in type 1 and type 2 diabetic patients: 24 hour heart rate variation and plasma motilin levels disturbed in parasympathetic neuropathy. Diabet Med 12: 1015-1021, 1995
19. Forsen A, Kangro M, Sterner G, Norrgren K, Thorsson O, Wollmer P, Sundkvist G: A 14-year prospective study of autonomic nerve function in type 1 diabetic patients: association with nephropathy. Diabet Med 21:852-858, 2004
20. Zanone MM, Peakman M, Purewal T, Watkins PJ, Vergani D: Autoantibodies to nervous tissue structures are associated with autonomic neuropathy in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36:564-569, 1993
21. Olsson ML, Sundkvist G, Lernmark A: Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:327-332, 1987
22. Borg H, Fernlund P, Sundkvist G: Measurement of antibodies against glutamic acid decarboxylase 65 (GADA): two new 125I assays compared with [35S]GAD 65-ligand binding assay. Clin Chem 43: 779-785, 1997
23. Sundkvist G, Almer L, Lilja B: Respiratory influence on heart rate in diabetes mellitus. Br Med J 1:924-925, 1979
24. Sundkvist G, Lilja B, Almer LO: Abnormal diastolic blood pressure and heart rate reactions to tilting in diabetes mellitus. Diabetologia 19:433-438, 1980
25. Bornmyr S, Svensson H, Lilja B, Sundkvist G: Skin temperature changes and changes in skin blood flow monitored with laser Doppler flowmetry and imaging: a methodological study in normal humans. Clin Physiol 17:71-81, 1997
26. Freccero C, Svensson H, Bornmyr S, Wollmer P, Sundkvist G: Sympathetic and parasympathetic neuropathy are frequent in both type 1 and type 2 diabetic patients. Diabetes Care 27:2936-2941, 2004
27. Husebye ES, Winqvist O, Sundkvist G, Kampe O, Karlsson FA: Autoantibodies against adrenal medulla in type 1 and type 2 diabetes mellitus: no evidence for an association with autonomic neuropathy. J Intern Med 239:139-146, 1996
28. Schnell O, Muhr D, Dresel S, Tatsch K, Ziegler AG, Haslbeck M, Standl E: Autoantibodies against sympathetic ganglia and evidence of cardiac sympathetic dysinnervation in newly diagnosed and long-term IDDM patients. Diabetologia 39: 970-975, 1996
29. Sundkvist G, Velloso LA, Kampe O, Rabinowe SL, Ivarsson SA, Lilja B, Karlsson FA: Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients. Diabetologia 37:293-299, 1994
30. Muhr D, Mollenhauer U, Ziegler AG, Haslbeck M, Standl E, Schnell O: Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy. Diabetes Care 20: 1009-1012, 1997
31. Zanone MM, Petersen JS, Peakman M, Mathias CJ, Watkins PJ, Dyrberg T, Vergani D: High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy. Diabetes 43:1146-1151, 1994
32. Borg H, Marcus C, Sjoblad S, Fernlund P, Sundkvist G: Islet cell antibody frequency differs from that of glutamic acid decarboxylase antibodies/IA2 antibodies after diagnosis of diabetes. Acta Paediatr 89: 46-51, 2000
33. Gilbey SG, Hussain MJ, Watkins PJ, Vergani D: Cell-mediated immunity and symptomatic diabetic autonomic neuropathy. Diabet Med 5:845-848, 1988
34. Guy RJ, Richards F, Edmonds ME, Watkins PJ: Diabetic autonomic neuropathy and iritis: an association suggesting an immunological cause. Br Med J (Clin Res Ed) 289:343-345, 1984
35. Pittenger GL, Liu D, Vinik AI: The neuronal toxic factor in serum of type 1 diabetic patients is a complement-fixing autoantibody. Diabet Med 12:380-386, 1995
36. Pittenger GL, Malik RA, Burcus N, Boulton AJ, Vinik AI: Specific fiber deficits in sensorimotor diabetic polyneuropathy correspond to cytotoxicity against neuroblastoma cells of sera from patients with diabetes. Diabetes Care 22:1839-1844, 1999