Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 69, Issue , 2004, Pages 125-129

  Kaneda, M ^a,b   Sado, T ^a,b,c   Hata, K ^a,b   Okano, M ^d,e   Tsujimoto, N ^e,f   Li, E ^e,f   Sasaki, H ^a,b  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d RIKEN   (Japan)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B;

AUTOSOME; CHROMOSOME ANALYSIS; CONFERENCE PAPER; DEVELOPMENT; DNA METHYLATION; EPIGENETICS; GENE; GENE FUNCTION; GENE SILENCING; GENOME IMPRINTING; GERM LINE; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; TRANSGENIC MOUSE; X CHROMOSOME; X CHROMOSOME INACTIVATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; MALE; MASH2 GENE; PHENOTYPE; RAT;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DNA MODIFICATION METHYLASES; DNA-BINDING PROTEINS; DOSAGE COMPENSATION, GENETIC; EMBRYONIC DEVELOPMENT; EPIGENESIS, GENETIC; FEMALE; GENOMIC IMPRINTING; MALE; MICE; MODELS, GENETIC; PREGNANCY; TRANSCRIPTION FACTORS;

MUS MUSCULUS;

EID: 23044457554     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2004.69.125     Document Type: Conference Paper

References (29)

1. Beard C., Li E., and Jaenisch R. 1995. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 9: 2325.
2. Bour'chis D., Xu G.L., Lin C.S., Bollman B., and Bestor T.H. 2001. Dnmt3L and the establishment of maternal genomic imprints. Science 294: 2536.
3. Brockdorff N. 2002. X-chromosome inactivation: Closing in on proteins that bind Xist RNA. Trends Genet. 18: 352.
4. Caspery T., Cleary M.A., Baker C.C., Guan X.-J., and Tilghman S.M. 1998. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol. Cell. Biol. 18: 3466.
5. Fitzpatrick G.V., Soloway P.D., and Higgins M.J. 2002. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat. Genet. 32: 426.
6. Goto Y. and Takagi N. 1998. Tetraploid embryos rescue embryonic lethality caused by an additional maternally derived X chromosome in the mouse. Development 125: 3353.
7. Guillemot F., Nagy A., Auerbach A., Rossant J., and Joyner A.L. 1994. Essential role of Mash-2 in extraembryonic development. Nature 371: 333.
8. Guillemot F., Caspary T., Tilghman S.M., Copeland N.G., Gilbert D.J., Jenkins N.A., Anderson D.J., Joyner, A.L., Rossant J., and Nagy A. 1995. Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat. Genet. 9: 235.
9. Hata K., Okano M., Lei H., and Li E. 2002. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 129: 1983.
10. Huynh K.D. and Lee J.T. 2003. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426: 857.
11. Kaneda M., Okano M., Hata K., Sado T., Tsujimoto N., Li E., and Sasaki H. 2004. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429: 900.
12. Lee J.T. 2003. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Curr. Biol. 13: R242.
13. Li E., Beard C., and Jaenisch R. 1993. Role for DNA methylation in genomic imprinting. Nature 366: 362.
14. Li E., Bestor T., and Jaenisch R. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915.
15. Lomeli H., Ramos-Mejia V., Gertsenstein M., Lobe C.G., and Nagy A. 2000. Targeted insertion of Cre recombinase into the TNAP gene: Excision in primordial germ cells. Genesis 26: 116.
16. Lyon M.F. 1961. Gene action in the X-chromosome of the mouse (Mus musculus L). Nature 190: 372.
17. Okamoto I., Tan S.-S., and Takagi N. 2000. X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation. Development 127: 4137.
18. Okamoto I., Otte A.P., Allis C.D., Reinberg D., and Heard E. 2004. Epigenetic dynamics of imprinted X-inactivation during early mouse development. Science 303: 644.
19. Okano M., Bell D.W., Haber D.A., and Li E. 1999. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247.
20. Panning B. and Jaenisch R. 1996. DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 10: 1991.
21. Reik W. and Walter J. 2001. Genomic imprinting: Parental influence on the genome. Nature Rev. Genet. 2: 21.
22. Sado T., Okano M., Li E., and Sasaki H. 2004. De novo methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development 131: 957.
23. Sado T., Fenner M.H., Tan S.-S., Tam P., Shioda T., and Li E. 2000. X-inactivation in the mouse embryo deficient for Dnmt1: Distinct effect of hypomethylation on imprinted and random X inactivation. Dev. Biol. 225: 294.
24. Sharman G.B. 1971. Late DNA replication in the paternally derived X chromosome of female kangaroos. Nature 230: 231.
25. Tada T., Obata Y., Tada M., Goto Y., Nakatsuji N., Tan S.-S., Kono T., and Takagi N. 2000. Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth. Development 127: 3101.
26. Takagi N. and Sasaki M. 1975. Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature 256: 640.
27. Takagi N., Sugimoto M., Yamaguchi S., Ito M., Tan S.-S., and Okabe M. 2002. Nonrandom X chromosome inactivation in mouse embryos carrying Searle's T(X;16)16H translocation visualized using X-linked lacZ and GFP transgenes. Cytogenet. Genome Res. 99: 52.
28. Tanaka M., Puchyr M., Gertsenstein M., Harpal K., Jaenisch R., Rossant J., and Nagy A. 1999. Parental-origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech. Dev. 87: 129.
29. Thornhill A.R. and Burgoyne P.S. 1993. A paternally imprinted X chromosome retards the development of the early mouse embryo. Development 118: 171.