JTP-27536 [(+)-1,3-dihydroxy-2-hydroxymethylpropyl-2-ammonium 2-[(R)-3-cyclo-hexyl-1-phenylpropyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5- carboxylate monohydrate], a novel inhibitor of immunoglobulins and interleukin-5 with anti-inflammatory properties in mouse allergic dermatitis model

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 1, 2005, Pages 293-301

  Mimura, Takayuki ^a   Shinozaki, Yuichi ^a   Kawasaki, Hisashi ^a   Iwamura, Hiroyuki ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIHYDROXY 2 HYDROXYMETHYLPROPYL 2 AMMONIUM 2 (3 CYCLOHEXYL 1 PHENYLPROPYL) 1,3 DIOXO 2,3 DIHYDRO 1H ISOINDOLE 5 CARBOXYLATE; 2,4 DINITROPHENOL; ANTIINFLAMMATORY AGENT; CYTOKINE RECEPTOR ANTAGONIST; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; JTP 27536; PICRYL CHLORIDE; PREDNISOLONE; SUPLATAST TOSYLATE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASCARIS; B LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; DRUG POTENCY; EDEMA; HUMAN; HUMAN CELL; IC 50; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SKIN ALLERGY; SKIN INFLAMMATION; SKIN SENSITIZATION; SPLEEN CELL; TH2 CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ASCARIS; B-LYMPHOCYTES; CHRONIC DISEASE; CYCLOHEXANES; DERMATITIS, ALLERGIC CONTACT; FEMALE; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULINS; INDOLES; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; PICRYL CHLORIDE; PREDNISOLONE; SPLEEN;

EID: 23044437505     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.080846     Document Type: Article

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