Ketamine inhibits inspiratory-evoked γ-aminobutyric acid and glycine neurotransmission to cardiac vagal neurons in the nucleus ambiguus

Anesthesiology

Volumn 103, Issue 2, 2005, Pages 353-359

  Wang, Xin ^a   Huang, Zheng Gui ^a   Dergacheva, Olga ^a   Bouairi, Evguenia ^a   Gorini, Christopher ^a   Stephens, Christopher ^a   Andresen, Michael C ^b   Mendelowitz, David ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; INTRAVENOUS ANESTHETIC AGENT; KETAMINE; N METHYL DEXTRO ASPARTIC ACID; STRYCHNINE;

AMBIGUUS NUCLEUS; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART RATE; INTRAVENOUS ANESTHESIA; MEDULLA OBLONGATA; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION; VAGUS NERVE;

EID: 23044435881     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200508000-00019     Document Type: Article

References (48)

1. Loewy AD, Spyer KM: Central Regulation of Autonomic Functions. Edited by Loewy AD, Spyer KM. New York, Oxford University Press, 1990, pp 68-87
2. Machado BH, Brody MJ: Role of the nucleus ambiguus in the regulation of heart rate and arterial pressure. Hypertension 1988; 11:602-7
3. McAllen RM, Spyer KM: The location of cardiac vagal preganglionic motoneurones in the medulla of the cat. J Physiol 1976; 258:187-204
4. Mendelowitz D, Kunze DL: Identification and dissociation of cardiovascular neurons from the medulla for patch clamp analysis. Neurosci Lett 1991; 132:217-21
5. Mendelowitz D: Firing properties of identified parasympathetic cardiac neurons in nucleus ambiguus. Am J Physiol 1996; 271:H2609-14
6. Neff RA, WangJ, Baxi S, Evans C, Mendelowitz D: Respiratory sinus arrhythmia: Endogenous activation of nicotinic receptors mediates respiratory modulation of brainstem cardioinhibitory parasympathetic neurons. Circ Res 2003; 93:565-72
7. Anrep G, Pascual F, Rossler R: Respiratory variations of the heart rate: II. The central mechanism of the respiratory sinus arrhythmia and the inter-relations between the central and the reflex mechanisms. Proc Royal Soc 1936; 119:218-32
8. Ogawa A, Uemura M, Kataoka Y, Ol K, Inokuchi T: Effects of ketamine on cardiovascular responses mediated by N-methyl-D-aspartate receptor in the rat nucleus tractus solitarius. ANESTHESIOLOGY 1993; 78:163-7
9. Bouairi E, Neff R, Evans C, Gold A, Andresen MC, Mendelowitz D: Respiratory sinus arrhythmia in freely moving and anesthetized rats. J Appl Physiol 2004; 97:1431-6
10. Blake DW, Korner PI: Effects of ketamine and Althesin anesthesia on baroreceptor-heart rate reflex and hemodynamics of intact and pontine rabbits. J Auton Nerv Syst 1982; 5:145-54
11. Sneyd JR: Recent advances in intravenous anaesthesia. Br J Anaesth 2004; 93:725-36
12. Sarton E, Teppema LJ, Olievier C, Nieuwenhuijs D, Matthes HW, Kieffer BL, Dahan A: The involvement of the mu-opioid receptor in ketamine-induced respiratory depression and antinociception. Anesth Analg 2001; 93:1495-500
13. Hornchen U, Tauberger G: Investigations on the mechanism of the effects of ketamine (Ketanest) on circulation and respiration [author's translation; in German]. Anaesthesist 1980; 29:547-51
14. Blake DW, Korner PI: Effects of ketamine and Althesin Anesthesia on baroreceptor-heart rate reflex and hemodynamics of intact and pontine rabbits. J Auton Nerv Syst 1982; 5:145-54
15. Traber DL, Wilson RD, Priano LL: The effect of beta-adrenergic blockade on the cardiopulmonary response to ketamine. Anesth Analg 1970; 49:604-13
16. Traber DL, Wilson RD, Priano LL: A detailed study of the cardiopulmonary response to ketamine and its blockade by atropine. South Med J 1970; 63:1077-81
17. Brown RH, Wagner EM: Mechanisms of bronchoprotection by anesthetic induction agents: Propofol versus ketamine. ANESTHESIOLOGY 1999; 90:822-8
18. Inoue K, Arndt JO: Efferent vagal discharge and heart rate in response to methohexitone, Althesin, ketamine and etomidate in cats. Br J Anaesth 1982; 54:1105-16
19. Institute of Laboratory Animal Resources: Guide for the Care and Use of Laboratory Animals, 7th edition. Washington, D.C., National Academy Press, 1996
20. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL: Pre-Botzinger complex: A brainstem region that may generate respiratory rhythm in mammals. Science 1991; 254:726-9
21. Wang J, Irnaten M, Venkatesan P, Evans C, Baxi S, Mendelowitz D: Synaptic activation of hypoglossal respiratory motorneurons during inspiration in rats. Neurosci Lett 2002; 332:195-9
22. White PF, Ham J, Way WL, Trevor AJ: Pharmacology of ketamine isomers in surgical patients. ANESTHESIOLOGY 1980; 52:231-9
23. Frenkel C, Duch DS, Urban BW: Effects of i.v. anaesthetics on human brain sodium channels. Br J Anaesth 1993; 71:15-24
24. Kaka JS, Hayton WL: Pharmacokinetics of ketamine and two metabolites in the dog. J Pharmacokinet Biopharm 1980; 8:193-202
25. Hara Y, Chugun A, Nakaya H, Kondo H: Tonic block of the sodium and calcium currents by ketamine in isolated guinea pig ventricular myocytes. J Vet Med Sci 1998; 60:479-83
26. Ko SH, Lee SK, Han YJ, Choe H, Kwak YG, Chae SW, Cho KP, Song HS: Blockade of myocardial ATP-sensitive potassium channels by ketamine. ANESTHESIOLOGY 1997; 87:68-74
27. Rekling JC, Feldman JL: PreBotzinger complex and pacemaker neurons: Hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol 1998; 60:385-405
28. Thoby-Brisson M, Telgkamp P, Ramirez JM: The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. J Neurosci 2000; 20:2994-3005
29. Foutz AS, Champagnat Denavit-Saubie MJ: Involvement of N-methyl-D-aspartate (NMDA) receptors in respiratory rhythmogenesis. Brain Res 1989; 500:199-208
30. Kress HG: Mechanisms of action of ketamine [in German]. Anaesthesist 1997; 46 suppl 1: S8-19
31. Smith JA, Santer LJ: Respiratory arrest following intramuscular ketamine injection in a 4-year-old child. Ann Emerg Med 1993; 22:613-5
32. Bourke DL, Malit LA, Smith TC: Respiratory interactions of ketamine and morphine. ANESTHESIOLOGY 1987; 66:153-6
33. Crambes A, Monassier L, Chapleau D, Roegel JC, Feldman J, Bousquet P: GABAergic and glutaminergic modulation of centrally evoked arrhythmias in rats. Hypertension 1996; 27:148-54
34. Wakasugi M, Hirota K, Roth SH, Ho Y: The effects of general anesthetics on excitatory and inhibitory synaptic transmission in area CA1 of the rat hippocampus in vitro. Anesth Analg 1999; 88:676-80
35. Suria A, Rasheed F: Evidence for involvement of amino acid neurotransmitters in anesthesia and naloxone induced reversal of respiratory paralysis. Life Sci 1994; 54:2021-33
36. Mascia MP, Machu TK, Harris RA: Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol 1996; 119:1331-6
37. Yamakura T, Chavez-Noriega LE, Harris RA: Subunit-dependent inhibition of human neuronal nicotinic acetylcholine receptors and other ligand-gated ion channels by dissociative anesthetics ketamine and dizocilpine. ANESTHESIOLGY 2000; 92:1144-53
38. Shao XM, Feldman JL: Mechanisms underlying regulation of respiratory pattern by nicotine in preBotzinger complex. J Neurophysiol 2001; 85:2461-7
39. Scheller M, Bufler J, Hertle I, Schneck HJ, Franke C, Kochs E: Ketamine blocks currents through mammalian nicotinic acetylcholine receptor channels by interaction with both the open and the closed state. Anesth Analg 1996; 83:830-6
40. Irnaten M, Wang J, Venkatesan P, Evans C, KS, KC, Andresen MC, Mendelowitz D: Ketamine inhibits presynaptic and postsynaptic nicotinic excitation of identified cardiac parasympathetic neurons in nucleus ambiguus. ANESTHESIOLOGY 2002; 96:667-74
41. Daly MD: Some reflex cardioinhibitory responses in the cat and their modulation by central inspiratory neuronal activity. J Physiol 1991; 439:559-77
42. Elghozi JL, Laude D, Girard A: Effects of respiration on blood pressure and heart rate variability in humans. Clin Exp Pharmacol Physiol 1991; 18:735-42
43. Hrushesky WJ: Quantitative respiratory sinus arrhythmia analysis: A simple noninvasive, reimbursable measure of cardiac wellness and dysfunction. Ann N Y Acad Sci 1991; 618:67-101
44. Shykoff BE, Naqvi SS, Menon AS, Slutsky AS: Respiratory sinus arrhythmia in dogs: Effects of phasic afferents and chemostimulation. J Clin Invest 1991; 87:1621-7
45. Spyer KM, Gilbey MP: Cardiorespiratory interactions in heart-rate control. Ann N Y Acad Sci 1988; 533:350-7
46. Inoue K, Miyake S, Kumashiro M, Ogata H, Yoshimura O: Power spectral analysis of heart rate variability in traumatic quadriplegic humans. Am J Physiol 1990; 258:H1722-6
47. Warner MR, deTarnowsky JM, Whitson CC, Loeb JM: Beat-by-beat modulation of AV conduction: II. Autonomic neural mechanisms. AmJ Physiol 1986; 251:H1134-42
48. Neff RA, Simmens SJ, Evans C, Mendelowitz D: Prenatal nicotine exposure alters Cardiorespiratory responses to hypoxia in rats: Implications for sudden infant death syndrome. J Neurosci 2004; 24:9261-8