Myofibroblasts correlate with lymphatic microvessel density and lymph node metastasis in early-stage invasive colorectal carcinoma

Anticancer Research

Volumn 25, Issue 4, 2005, Pages 2705-2712

  Liang, Pin ^a,b   Hong, Jian Wei ^a   Ubukata, Hideyuki ^a   Liu, Ge ^a   Katano, Motonobu ^a   Motohashi, Gyo ^a   Kasuga, Teruhiko ^a   Watanabe, Yoshinori ^a   Nakada, Ichiro ^a   Tabuchi, Takafumi ^a  

^a Tokyo Medical University Ibaraki Medical Center   (Japan)

^b NONE   (Japan)

Author keywords

Early stage colorectal carcinoma; Lymph node metastasis; Lymphangiogenesis; Microvessel density; Myofibroblast; Podoplanin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; PODOPLANIN;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; MYOFIBROBLAST; PRIORITY JOURNAL;

ACTINS; ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS;

EID: 22944491767     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hom YK, Young P, Wiesen JF et al: Uterine and vaginal organ growth requires epidermal growth factor receptor signaling from stroma. Endocrinology 139: 913-921, 1998.
2. Ogawa H, Iwaya K, Izumi M, Kuroda M, Serizawa H, Koyanagi Y et al: Expression of CD10 by stromal cells during colorectal tumor development. Hum Pathol 33: 806-811, 2002.
3. Li C, Gardy R, Seor BK et al: Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis. Br J Cancer 88: 1424-1431, 2002.
4. Nakada I, Tasaki T, Ubukata H, Goto Y, Wantanabe Y, Sato S, Tabuchi T et al: Desmoplastic response in biopsy specimens of early colorectal carcinoma is predictive of deep submucosal invasion. Dis Colon Rectum 41: 896-900, 1998.
5. Martin M, Pujuguet P and Martin F: Role of stromal myofibroblasts infiltrating colon cancer in tumor invasion. Path Res Pract 192: 712-717, 1996.
6. Lieubeau B, Garrigue L, Barbieux I, Meflash K and Gregoire M: The role of transforming growth factor beta 1 in the fibroblastic reaction associated with rat colorectal tumor development. Cancer Res 54(24): 6526-6532, 1994.
7. Zidar N, Gale N, Kambic V and Fischinger J: Proliferation of myofibroblasts in the stroma of epithelial hyperplastic lesions and squamous carcinoma of the larynx. Oncol 62: 381-385, 2002.
8. Weninger W, Partanen TA, Breiteneder-Geleff S, Mayer C, Kowalski H, Mildner M et al: Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest 79: 243-251, 1999.
9. Valencak J, Heere-Ress E, Kopp T, Schoppmann SF, Kittler H, Pehamberger H et al: Selective immunohistochemical staining shows significant prognostic influence of lymphatic and blood vessels in patients with malignant melanoma. Eur J Cancer 40: 358-364, 2004.
10. Kitamura K, Taniguchi H, Yamaguchi T, Sawai K, Takahashi T et al: Clinical outcome of surgical treatment for invasive early colorectal cancer in Japan. Hepatogast 44: 108-115, 1997.
11. Hermanek P and Gall FP: Early (microinvasive) colorectal carcinoma, pathology, diagnosis, surgical treatment. Int J Colored Dis 1: 79-84, 1986.
12. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal Carcinoma. First English Edition. Kanehara & Co., Lid., Tokyo, 1997.
13. Kudo S: Endoscopic mucosal resection of flat and depressed type of early colorectal cancer. Endoscopy 25: 455-461, 1993.
14. Lee H, Douglas-Jones AG, Morgan JM and Jasani B: The effect of fixation and processing on the sensitivity of oestrogen receptor assay by immunohistochemistry in breast carcinoma. J Clin Pathol 55: 236-238, 2002.
15. Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
16. Straume O, Jackson DG and Akslen LA: Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 9: 250-256, 2003.
17. Hewitt RE, Powe DG, Carter GI and Turner DR: Desmoplasia and its relevance to colorectal tumor invasion. Int J Cancer 53: 62-69, 1993.
18. Peter B, Monika S, Andreas O, Gerhard B, Heinrich K, Georg O et al: Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. Int J Cancer 95: 29-33, 2001.
19. Schurich W, Seemayer TA and Gbbiani G: The myofibroblast: a quarter century after its discovery. Am J Surg Pathol 22: 141-147, 1998.
20. Balazs M and Kovacs A: Electron microscopic study of carcinoma of the colon. Exp Path 20: 203-214, 1981.
21. Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK and Seed R: Tumor induction of VEGF promoter activity in stromal cells. Cell 94: 715-725, 1998.
22. Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K and Drtmar M: Induction of tumor lymphangiogenesis by VEGF-C promoters breast cancer metastasis. Nat Med 7: 192-198, 2001.
23. Curti BD, Urba WJ, Alvord WG, Janik JE, Smith JW II, Madara K and Longo DL: Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res 53: 2204-2207, 1993.
24. Padera TP, Kadambi A, Tomaso ED, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D and Wain J: Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296: 1883-1886, 2002.
25. Pourreyron C, Dumortier J, Ratineau C, Nejjari M, Beatrix O, Jacquier MF, Remy L, Chayvialle JA and Scoazec JY: Age-dependent variations of human and rat colon myofibroblasts in culture: influence on their functional interactions with colon cancer cells. Int J Cancer 104(1): 28-35, 2003.
26. Ban S, Kamada K, Mitsuki N, Goto Y, Shimizu Y, Tskahama M and Shibata T: Phenotypic change of muscosae in early invasive colorectal adenocarcinoma. J Clin Pathol 53: 878-881, 2000.
27. Nakayama H, Enzan H, Miyazaki E and Toi M: α-Smooth muscle actin positive stromal cells in gastric carcinoma. J Clin Pathol 55: 741-744, 2002.
28. Koretz K, Moller P and Schwartz-Albiez R: Plasminogen activators and plasminogen inhibitors in human colorectal carcinoma tissues are not expressed by the tumor cells. Eur J Cancer 29A: 1184-1189, 1993.
29. Pyke C, Ralfkiaer E, Tryggvason K and Dano K: Messenger RNA for two type IV collagenases is located in stromal cells in human colon adenocarcinomas. Am J Pathol 142: 359-365, 1993.
30. Brodsky JT, Richard GK, Cohen AM and Minisky BD: Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 69(2): 322-326, 1992.