Hypoxaemia during open-airway apnoea: A computational modelling analysis

Anaesthesia

Volumn 60, Issue 8, 2005, Pages 741-746

  McNamara, M J ^a   Hardman, J G ^b  

^a GOLD COAST UNIVERSITY HOSPITAL   (Australia)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; OXYGEN;

AIRWAY CONDUCTANCE; AMBIENT AIR; AMBIENT OXYGEN FRACTION; ANESTHESIOLOGICAL TECHNIQUES; APNEA; ARTERIAL OXYGEN TENSION; ARTICLE; BRAIN DEATH; BRAIN STEM; COMPUTER SIMULATION; HEART OUTPUT; HYPOXEMIA; OXYGEN THERAPY; REPRODUCIBILITY; SHUNTING;

ANOXEMIA; APNEA; CARBON DIOXIDE; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; OXYGEN; PARTIAL PRESSURE; REPRODUCIBILITY OF RESULTS;

EID: 22944478016     PISSN: 00032409     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2044.2005.04228.x     Document Type: Article

References (26)

1. Canadian Neurocritical Care Group. Guidelines for the diagnosis of brain death. Canadian Journal of Neurological Science 1999; 26: 64-6.
2. Wijdicks EF. The diagnosis of brain death. New England Journal of Medicine 2001; 344: 1215-21.
3. Allen N, Burkholder J, Comiscioni J. Clinical criteria of brain death. Annals of the New York Academy of Science 1978; 315: 70-96.
4. Belsh JM, Blatt R, Schiffman PL. Apnoea testing in brain death. Archives of Internal Medicine 1986; 146: 2385-8.
5. Hardman JG, Wills JS, Aitkenhead AR. Investigating hypoxaemia during apnoea: validation of a set of physiological models. Anesthesia and Analgesia 2000; 90: 614-8.
6. Hardman JG, Bedforth NM, Ahmed AB, et al. A physiology simulator: validation of its respiratory components and its ability to predict the patient's response to changes in mechanical ventilation. British Journal of Anaesthesia 1998; 81: 327-32.
7. Hardman JG, Bedforth NM. Estimating venous admixture using a physiological simulator. British Journal of Anaesthesia 1999; 82: 346-9.
8. Bedforth NM, Hardman JG. Predicting patients' responses to changes in mechanical ventilation: a comparison between physicians and a physiological simulator. Intensive Care Medicine 1999; 25: 839-42.
9. 2: a factor analysis using a physiological simulation. Anaesthesia and Intensive Care 1999; 27: 452-8.
10. al Jumah M, McLean DR, al Rajeh S, Crow N. Bulk diffusion apnoea test in the diagnosis of brain death. Critical Care Medicine 1992; 20: 1564-7.
11. Marks SJ, Zisfein J. Apnoeic oxygenation in apnoea tests for brain death. A controlled trial. Archives of Neurology 1990; 47: 1066-8.
12. Feery J, Waller G, Solliday N. The use of apnoeic-diffusion respiration in the diagnosis of brain death. Respiratory Care 1985; 30: 328-33.
13. Benzel EC, Gross CD, Hadden TA, et al. The apnoea test for the determination of brain death. Journal of Neurosurgery 1989; 71: 191-4.
14. Damia G, Mascheroni D, Croci M, Tarenzi L. Perioperative changes in functional residual capacity in morbidly obese patients. British Journal of Anaesthesia 1988; 60: 574-8.
15. Wahba RW. Perioperative functional residual capacity. Canadian Journal of Anaesthesia 1991; 38: 384-400.
16. Frumin MJ, Epstein RM, Cohen G. Apnoeic oxygenation in man. Anesthesiology 1959; 20: 789-98.
17. Holmdahl MH. Pulmonary uptake of oxygen, acid-base metabolism, and circulation during prolonged apnoea. Acta Chirurgica Scandinavia 1956; 212 (Suppl.): 1-128.
18. Nunn JF. Nunn's Applied Respiratory Physiology, 4th edn. Oxford: Butterworth-Heineman, 1993.
19. Payne JP. Apnoeic oxygenation in anaesthetised man. Acta Anaesthesiologica Scandinavica 1962; 6: 129.
20. Keilson MJ. Apnoeic oxygenation in apnoea tests. Archives of Neurology 1991; 48: 789-90.
21. Fraioli RL, Sheffer LA, Steffenson JL. Pulmonary and cardiovascular effects of apnoeic oxygenation in man. Anesthesiology 1973; 39: 588-96.
22. Ropper AH, Kennedy SK, Russell L. Apnoea testing in the diagnosis of brain death. Clinical and physiological observations. Journal of Neurosurgery 1981; 55: 942-6.
23. Hardman JG, Wills JS, Aitkenhead AR. Factors determining the onset and course of hypoxaemia during apnoea: an investigation using physiological modelling. Anesthesia and Analgesia 2000; 90: 619-24.
24. Pitts LH. Determination of brain death. Western Journal of Medicine 1984; 140: 628-31.
25. Perel A, Berger M, Cotev S. The use of continuous flow of oxygen and PEEP during apnoea in the diagnosis of brain death. Intensive Care Medicine 1983; 9: 25-7.
26. 2 and apnoea testing for brain stem death. Anaesthesia 1997; 52: 87.