Is low-risk hypertension fact or fiction? Cardiovascular risk profile in the TROPHY study

American Journal of Hypertension

Volumn 18, Issue 7, 2005, Pages 980-985

  Nesbitt, Shawna D ^a,e   Julius, Stevo ^b   Leonard, David ^a   Egan, Brent M ^c   Grozinski, Melissa ^d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d ASTRAZENECA   (United Kingdom)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Angiotensin receptor blocker; Candesartan cilexetil; Cardiovascular disease risk factors; High normal blood pressure; Prehypertension; Prevention

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DIET RESTRICTION; FEMALE; HEART RATE; HEMATOCRIT; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; OBESITY; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BODY MASS INDEX; CLUSTER ANALYSIS; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; RISK FACTORS; SEX FACTORS; UNITED STATES;

EID: 22844441621     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2005.01.021     Document Type: Article

References (41)

1. R.S. Vasan, M.G. Larson, E.P. Leip, J.C. Evans, C.J. O'Donnell, W.B. Kannel, D. Levy Impact of high normal blood pressure on the risk of cardiovascular disease N Engl J Med 345 2001 1291 1297
2. S.D. Nesbitt, S. Julius Prehypertension a possible target for antihypertensive medication Curr Hypertens Rep 2 2000 356 361
3. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, R.C. Turner Homeostasis model assessment Insulin resistance and B cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
4. K.J. Mather, A.E. Hunt, H.O. Steinberg, G. Paradisi, G. Hook, A. Katz, M.J. Quon, A.D. Baron Repeatability characteristics of simple indices of insulin resistance implications for research applications J Clin Endocrinol Metab 86 2001 5457 5464
5. E. Bonora, G. Targher, M. Alberiche, R.C. Bonadonna, F. Saggiani, M.B. Zenere, T. Monauni, M. Muggeo Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity studies in subjects with various degrees of glucose tolerance and insulin sensitivity Diabetes Care 23 2000 57 63
6. Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) J Am Med Assoc 285 2001 2486 2497
7. American Diabetes Association Screening for diabetes Diabetes Care 24 2001 S21 S24
8. S. Julius, P. Palatini, S.D. Nesbitt Tachycardia an important determinant of coronary risk in hypertension J Hypertens 16 1998 S9 S15
9. W.B. Kannel, C. Kannel, R.S. Paffenbarger Jr, L.A. Cupples Heart rate and cardiovascular mortality the Framingham Study Am Heart J 113 1987 1489 1494
10. S. Smith (Nesbitt), S. Julius, K. Jamerson, J. Amerena, N. Schork Hematocrit levels and physiologic factors in relationship to cardiovascular risk in Tecumseh, Michigan J Hypertens 12 1994 455 462
11. M. Cirillo, M. Laurenzi, M. Trevisan, J. Stamler Hematocrit, blood pressure, and hypertension. The Gubbio Population Study Hypertension 20 1992 319 326
12. E.S. Ford, W.H. Giles, W.H. Dietz Prevalence of the metabolic syndrome among US adults J Am Med Assoc 287 2002 356 359
13. Centers for Disease Control and Prevention. The Third National Health and Nutrition Examination Survey (NHANES III 1988-1994) CD ROM.
14. Centers for Disease Control and Prevention. The Third National Health and Nutrition Examination Survey (NHANES III 1999-2000) CD ROM.
15. E.S. Ford, A.H. Mokdad, W.H. Giles, G.A. Mensah Serum total cholesterol concentrations and awareness, treatment, and control of hypercholesterolemia among US adults. Findings from the Third National Health and Nutrition Survey, 1999 to 2000 Circulation 107 2003 2185 2189
16. K.J. Greenlund, J.B. Croft, G.A. Mensah Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States, 1999-2000 Arch Intern Med 164 2004 2113 2118
17. J.L. Whyte, G.J. L'Italien, R.S. Chen, G.R. Williams, J. Ninommyia, A. Gamast, M.H. Criqui The prevalence of the metabolic syndrome and its associated CHD risk in the United States [Abstract]. The 62nd Scientific Sessions, American Diabetes Association. Abstract 979-P Diabetes 51 2002 A241 A242
18. Z.T. Bloomgarden Obesity, hypertension, and insulin resistance Diabetes Care 25 2002 2088 2097
19. G.M. Reaven Banting lecture. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
20. G.M. Reaven Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease J Clin Endocrinol Metab 88 2003 2399 2403
21. S. Julius, S. Nesbitt Sympathetic overactivity in hypertension Am J Hypertens 9 1996 113S 120S
22. S. Julius, M. Valentini, P. Palatini Overweight and hypertension a 2-way street? Hypertension 35 2000 807 813
23. S. Julius, K. Jamerson, A. Mejia, L. Krause, N. Schork, K. Jones The association of borderline hypertension with target organ changes and higher coronary risk Tecumseh Blood Pressure Study J Am Med Assoc 264 1990 354 358
24. L. Landsberg Insulin-mediated sympathetic stimulation role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why) J Hypertens 19 2001 523 528
25. J.E. Hall, D.A. Hildebrandt, J. Kuo Obesity hypertension role of leptin and sympathetic nervous system Am J Hypertension 14 2001 103S 115S
26. G.L. Vega Cardiovascular outcomes for obesity and metabolic syndrome Obes Res 10 2002 27S 32S
27. K.M. Flegal, M.D. Carroll, C.L. Ogden, C.L. Johnson Prevalence and trends in obesity among US adults, 1999-2000 J Am Med Assoc 288 2002 1723 1727
28. M.K. Rutter, H. Parise, E.J. Benjamin, D. Levy, M.G. Larson, J.B. Meigs, R.W. Nesto, P.W. Wilson, R.S. Vasan Impact of glucose intolerance and insulin resistance on cardiac structure and function. Sex-related differences in the Framingham Heart Study Circulation 107 2003 448 454
29. A.V. Chobanion, G.L. Bakris, H.R. Black, W.C. Cushman, L.A. Green, J.L. Izzo Jr, D.W. Jones, B.J. Materson, S. Oparil, J.T. Wright Jr, E.J. Roccella The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure the JNC 7 Report J Am Med Assoc 289 2003 2560 2572
30. K.J. Greenlund, J.B. Croft, G.A. Mensah Prevalence of heart disease and stroke risk factors in persons with prehypertension in the United States, 1999-2000 Arch Intern Med 164 2004 2113 2118
31. Heart Disease and Stroke Statistics 2003 Update. American Heart Association, Dallas, TX.
32. International Society of Hypertension Writing Group International Society of Hypertension (ISH) statement on blood pressure lowering and stroke prevention J Hypertens 21 2003 651 663
33. Prospective Studies Collaboration Age-specific relevance of usual blood pressure to vascular mortality a meta-analysis of individual data for one million adults in 61 prospective studies Lancet 360 2002 1903 1913
34. F.M. Sacks, L.P. Svetkey, W.M. Vollmer, L.J. Appel, G.A. Bray, D. Harsha, E. Obarzanek, P.R. Conlin, E.R. Miller 3rd, D.G. Simons-Morton, N. Karanja, P.H. Lin DASH-Sodium Collaborative Research Group Effects on blood pressure of reduced dietary sodium and the Dietary Approach to Stop Hypertension (DASH) diet N Engl J Med 344 2001 3 10
35. L.J. Appel, T.J. Moore, E. Obarzanek, W.M. Vollmer, L.P. Svetkey, F.M. Sacks, G.A. Bray, T.M. Vogt, J.A. Cutler, M.M. Windhauser, P.H. Lin, N. Karanja The DASH Collaborative Research Group A clinical trial of the effects of dietary patterns on blood pressure N Engl J Med 336 1997 1117 1124
36. Hypertension Prevention Trial Research Group The Hypertension Prevention Trial three-year effects of dietary changes on blood pressure Arch Intern Med 150 1990 153 162
37. Trials of Hypertension Prevention Collaborative Research Group Effects of weight loss and sodium reduction intervention on blood pressure in overweight people with high normal blood pressure Arch Intern Med 157 1997 657 667
38. H.G. Langford, B.R. Davis, D. Blaufox, A. Oberman, S. Wassertheil-Smoller, M. Hawkins, N. Zimbaldi The TAIM Research Group Effect of drug and diet treatment of mild hypertension on diastolic blood pressure Hypertension 17 1991 210 217
39. PREMIER Collaborative Research Group Effects of comprehensive lifestyle modification on blood pressure control J Am Med Assoc 289 2003 2083 2093
40. L.H. Opie, R. Schall Old antihypertensives and new diabetes J Hypertens 22 2004 1453 1458
41. S. Julius, S.E. Kjeldsen, M. Weber, H.R. Brunner, S. Ekman, L. Hansson, T. Hua, J. Laragh, G.T. McInnes, L. Mitchell, F. Plat, A. Schork, B. Smith, A. Zanchetti VALUE Trial Group Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine the VALUE randomized trial Lancet 363 2004 2022 2031