Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors

British Journal of Pharmacology

Volumn 145, Issue 5, 2005, Pages 656-663

  Schlesinger, Friedrich ^a   Tammena, Derk ^a   Krampfl, Klaus ^a   Bufler, Johannes ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Block mechanism; Human AMPA type receptors; Patch clamp; Ultrafast application

Indexed keywords

1 (1 ADAMANTYLMETHYLAMMONIO) 5 TRIMETHYLAMMONIOPENTANE DIBROMIDE; ADAMANTANE DERIVATIVE; GLUTAMATE RECEPTOR; LYSINE; MUTANT PROTEIN; RECOMBINANT PROTEIN; TYROSINE;

ARTICLE; BINDING SITE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; NEUROPROTECTION; NEUROTRANSMISSION; PATCH CLAMP; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RECEPTOR BLOCKING; STROKE;

ADAMANTANE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, AMPA;

EID: 22744458867     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706233     Document Type: Article

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