The cardiovascular actions of anandamide: More targets?

British Journal of Pharmacology

Volumn 145, Issue 5, 2005, Pages 565-566

  Randall, Michael D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

2 adrenoceptors; Anandamide; Cannabinoids; In vivo responses; NMDA receptors; Pressor actions

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ANANDAMIDE; ANESTHETIC AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; DOPAMINE DERIVATIVE; N ARACHIDONYLDOPAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTOBARBITAL; PROPRANOLOL; RIMONABANT; UNCLASSIFIED DRUG; URETHAN; VANILLOID RECEPTOR 1;

AUTONOMIC NERVOUS SYSTEM; CARDIOVASCULAR EFFECT; DRUG RESPONSE; DRUG TARGETING; GABAERGIC TRANSMISSION; GENERAL ANESTHESIA; GLUTAMATERGIC SYSTEM; IN VIVO STUDY; NEUROTRANSMISSION; NONHUMAN; NOTE; PRESSOR RESPONSE; PRIORITY JOURNAL;

ANIMALS; ARACHIDONIC ACIDS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; HEMODYNAMIC PROCESSES; POLYUNSATURATED ALKAMIDES; RATS; RECEPTORS, CANNABINOID;

EID: 22744454519     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706234     Document Type: Note

References (8)

1. GARDINER, S.M., MARCH, J.E., KEMP, P.A. & BENNETT, T. (2002). Complex regional haemodynamic effects of anandamide in conscious rats. Br. J. Pharmacol., 135, 1889-1896.
2. KWOLEK, G., ZAKRZESKA, A., SCHLICKER, E., GOTHERT, M., GODLEWSKI, G. & MALINOWSKA, B. (2005). Central and peripheral components of the pressor effect of anandamide in urethaneanaesthetized rats. Br. J. Pharmacol., 145, 567-575 (this issue).
3. LAKE, K.D., MARTIN, B.R., KUNOS, G. & VARGA, K. (1997). Cardiovascular effects of anandamide in anaesthetized and conscious normotensive rats. Hypertension, 29, 1204-1210.
4. MALINOWSKA, B., KWOLEK, G. & GOTHERT, M. (2001). Anandamide and methanandamide induce both vanilloid VR1- and cannabinoid CB1 receptor mediated changes in heart rate and blood pressure in anaesthetized rats. Nauyn-Schmiedeberg's Arch. Pharmacol., 364, 562-569.
5. PADLEY, J.R., LI, Q., PILOWSKY, P.M. & GOODCHILD, A.K. (2003). Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetised rats. Br. J. Pharmacol., 140, 384-394.
6. RANDALL, M.D., KENDALL, D.A. & O'SULLIVAN, S.E. (2004). The complexities of the cardiovascular actions of cannabinoids. Br. J. Pharmacol., 142, 20-26.
7. SEACARD, J.L., DEAN, C., PATEL, S., RADEMACHER, D.J., HOPP, F.A., SCMELING, W.T. & HILLIARD, C.J. (2004). Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreceptor-evoked sympathoinhibition. Am. J. Physiol., 286, H992-H1000.
8. STEIN, E.A., FULLER, S.A., EDGEMOND, W.S. & CAMPBELL, W.B. (1996). Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamine (anandamide), in the rat. Br J Pharmacol., 119, 107-114.