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Reductive coupling on a broad spectrum of carbonyl and azomethine derivatives has been the subject of many recent investigations, exemplified by the following: (a) A. Fürstner, A. Hupperts, A. Ptock, and E. Janssen J. Org. Chem. 59 1994 5215;
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(f) D.-Q. Shi, J.-X. Chen, W.-Y. Chai, W.-X. Chen, and T.-Y. Kao Tetrahedron Lett. 1993 2963;
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(g) J.-X Chen, W.-Y. Chai, J.-L. Zhu, J. Gao, W.-X. Chen, and T.-Y. Kao Synthesis 1993 87;
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J.J. Eisch, X. Shi, and F.A. Owuor Oganometallics 17 1998 5219:the preliminary communication of the synthesis of ansa-metallocenes by reductive dimerization of fulvenes
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For previously known methods of metallocene synthesis, the following references may be helpful: (a) R.B. King, in: J.J. Eisch, R.B. King (Eds.), Organometallic Syntheses, vol. 2, Academic Press, New York, 1966, p. 64;
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(b) K.M. Kane, P.J. Shapiro, A. Vij, R. Cubbon, and A.L. Rheingold Organometallics 16 1997 4567;
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J.J. Eisch, F.A. Owuor, and X. Shi Organometallics 18 1999 1583:the preliminary communication of the synthesis of Group 4 bis(substituted- cyclopentadienyl)metal dichlorides by the transfer-hydrometallation of fulvenes
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Wiley, New York, Chapters 2 and 13.
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N2 reactions, where the steric hindrance between substituents in such backside-attack raises the energy of the transition state (below). Also in equilibria of Lewis acid-Lewis base complexation, such as in R 3 ′ N - BR 3 adduct formation, greater F-strain between the R and R′ groups promotes complex dissociation. Cf. M.S. Newman Steric effects in organic chemistry 1956 Wiley New York (Chapters 2 and 13).
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nNH • HBr, the rate of closure to the aziridine (n = 2) is faster by 100-fold than the closure to the azetidine (n = 3): G. Salomon Helv. Chim. Acta 19 1936 743
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K. Ziegler, H.G. Gellert, H. Martin, K. Nagel, and J. Schneider Liebigs Ann. Chem. 589 1954 91
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J.J. Eisch, A.M. Piotrowski, S.K. Brownstein, E.J. Gabe, and F.L. Lee J. Am. Chem. Soc. 107 1985 7219
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