P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia

Psychiatry Research

Volumn 136, Issue 1, 2005, Pages 27-34

  Louchart De La Chapelle, Sandrine ^a   Levillain, Daniel ^b   Ménard, Jean François ^a   Van Der Elst, Alexis ^a   Allio, Gabrielle ^a   Haouzir, Sadeq ^a   Dollfus, Sonia ^c   Campion, Dominique ^a   Thibaut, Florence ^a  

^a HÔPITAL CHARLES NICOLLE   (France)

^b CHS du Rouvray   (France)

^c CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

Auditory evoked potentials; Electrophysiology; Negative symptoms; P50; Schizophrenia; Sensory gating

Indexed keywords

PROTEIN P50;

ADULT; ARTICLE; AUDITORY STIMULATION; CHANNEL GATING; CLINICAL FEATURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED AUDITORY RESPONSE; FEMALE; HUMAN; LATENT PERIOD; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSORY SYSTEM; SYMPTOMATOLOGY;

ADULT; CONDITIONING (PSYCHOLOGY); ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; EYE MOVEMENTS; FEMALE; HUMANS; MALE; NEURAL INHIBITION; SCHIZOPHRENIA; SENSATION DISORDERS; SEVERITY OF ILLNESS INDEX; SUPINE POSITION;

EID: 22744447787     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2003.04.001     Document Type: Article

References (38)

1. L.E. Adler, E. Pachtman, R.D. Franks, M. Pecevich, M.C. Waldo, and R. Freedman Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia Biological Psychiatry 17 1982 639 654
2. L.E. Adler, M.C. Waldo, A. Tatcher, E. Cawthra, and N. Baker Lack of relationship of auditory sensory gating defects to negative symptoms in schizophrenia Schizophrenia Research 3 1990 131 138
3. L.E. Adler, L.D. Hoffer, A. Wiser, and R. Freedman Normalization of auditory physiology by cigarette smoking in schizophrenic patients American Journal of Psychiatry 150 1993 1856 1861
4. K.J. Aitchison, R.M. Meehan, and R. Murray First Episode Psychosis 1999 Martin-Dunitz Ed. London 138 pp.
5. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 APA Washington, DC
6. N.J. Baker, M. Staunton, L.E. Adler, G.A. Gerhardt, C. Drebing, M. Waldo, H. Nagamoto, and R. Freedman Sensory gating deficits in psychiatric inpatients: relation to catecholamine metabolites in different diagnostic groups Biological Psychiatry 27 1990 519 528
7. N. Boutros Dopamine and the P50 Biological Psychiatry 44 1998 932 938
8. N. Boutros, G. Zouridakis, and J. Overall Replication and extension of P50 findings in schizophrenia Clinical Electroencephalography 22 1991 40 45
9. D.L. Braff Information processing and attention dysfunctions in schizophrenia Schizophrenia Bulletin 19 1993 233 259
10. K.S. Cadenhead, G.A. Light, M.A. Geyer, and D.L. Braff Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypical personality disorder American Journal of Psychiatry 157 2000 55 59
11. B.A. Clementz, M.A. Geyer, and D.L. Braff P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis Biological Psychiatry 41 1997 1035 1044
12. R.J. Croft, A. Lee, J. Bertolot, and J.H. Gruzelier Association of P50 suppression and desensitization with perceptual and cognitive features of "unreality" in schizotypy Biological Psychiatry 50 2001 441 446
13. G. Fein, C. Biggins, and S. MacKay Cocaine abusers have reduced auditory P50 amplitude and suppression compared to both normal controls and alcoholics Biological Psychiatry 39 1996 955 965
14. P. Foster Neuroleptic equivalence Pharmacology Journal 30 1989 431 432
15. D.R. Franks, L.E. Alder, M.C. Waldo, J. Alpert, and R. Freedman Neurophysiobiological studies of sensory gating in mania. Comparison with schizophrenia Biological Psychiatry 18 1983 989 1005
16. R. Freedman, L.E. Adler, M.C. Waldo, E. Pachtman, and R.D. Franks Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients Biological Psychiatry 18 1983 537 551
17. R. Freedman, L.E. Adler, G.A. Gerhardt, M. Waldo, N. Baker, G.M. Rose, C. Drebing, H. Nagamoto, P. Bickford-Wimer, and R. Franks Neurobiological studies of sensory gating in schizophrenia Schizophrenia Bulletin 13 1987 669 678
18. R. Freedman, L.E. Adler, and M. Waldo Gating of the auditory evoked potential in children and adults Psychophysiology 24 1987 223 227
19. R. Freedman, H. Coon, M. Myles-Worsley, A. Orr-Urteger, A. Olincy, A. Davis, M. Polymeropoulos, J. Holik, J. Hopkins, M. Hoff, J. Rosenthal, M.C. Waldo, F. Reimherr, P. Wender, J. Yaw, D.A. Young, C.R. Breese, C. Adams, D. Patterson, L.E. Adler, L. Kruglyak, S. Leonard, and W. Byerley Linkage of a neurophysiological deficit in schizophrenia to chromosome 15 locus Proceedings of the National Academy of Sciences of the United States of America 94 1997 587 592
20. A.J. Fyer, J. Endicott, S. Manuzza, and D.F. Klein Schedule for Affective Disorders and Schizophrenia-Lifetime Version Modified for the Study of Anxiety Disorders 1985 New York State Psychiatric Institute New York
21. W.P. Hetrick, C.A. Sandman, W.E. Bunney Jr., Y. Jin, S.G. Potkin, and M.H. White Gender differences in gating of the auditory evoked potential in normal subjects Biological Psychiatry 39 1996 51 58
22. Y. Jin, W.E. Bunney, C.A. Sandman, J.V. Patterson, K. Fleming, J.R. Moenter, A.H. Kalali, W.P. Hetrick, and S.G. Potkin Is P50 suppression a measure of sensory gating in schizophrenia? Biological Psychiatry 43 1998 873 878
23. N. Kathmann, and R.R. Engel Sensory gating in normals and schizophrenics: a failure to find strong P50 suppression in normals Biological Psychiatry 27 1990 1216 1226
24. S.R. Kay, A. Fiszbein, and L.A. Opler The positive and negative syndrome scale (PANSS) for schizophrenia Schizophrenia Bulletin 13 1987 261 276
25. G.A. Light, and D.L. Braff Human and animal studies of schizophrenia-related gating deficits Current Psychiatry Reports 1 1999 31 40
26. G.A. Light, and D.L. Braff Do self-reports of perceptual anomalies reflect gating deficits in schizophrenia patients? Biological Psychiatry 47 2000 463 467
27. A. McGhie, and J. Chapman Disorders of attention in early schizophrenia British Journal of Medical Psychology 34 1961 103 116
28. H.T. Nagamoto, L.E. Adler, M.C. Waldo, J. Griffith, and R. Freedman Gating of auditory response in schizophrenics and normal controls. Effects of recording site and stimulation interval on the P50 wave Schizophrenia Research 4 1991 31 40
29. K.H. Nuerchterlein, and M.E. Dawson Information processing and attentional functioning in the developmental course of schizophrenic disorders Schizophrenia Bulletin 10 1984 160 203
30. J.V. Patterson, Y. Jin, B.S. Glerczak, W.P. Herrick, S. Potkin, W.E. Bunney, and C.A. Sandman Effects of temporal variability on P50 and the gating ratio in schizophrenia Archives of General Psychiatry 57 2000 57 64
31. G. Raux, F. Bonnet-Brilhault, S. Louchart, E. Houy, R. Gantier, D. Levillain, G. Allio, S. Haouzir, M. Petit, M. Martinez, T. Frebourg, F. Thibaut, and D. Campion The -2bp deletion in exon 6 of the alpha 7-like nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit Molecular Psychiatry 7 2002 1006 1011
32. L.N. Robins, J.E. Helzen, J. Croughan, and K.S. Ratcliff National institute of mental health diagnostic interview schedule: its history characteristics and validity Archives of General Psychiatry 38 1981 381 389
33. C. Siegel, M.C. Waldo, C. Mizner, L.E. Adler, and R. Freedman Deficit in sensory gating in schizophrenia patients and their relatives Archives of General Psychiatry 41 1984 607 612
34. F. Thibaut, J.M. Ribeyre, N. Dourmap, J.F. Ménard, S. Dollfus, and M. Petit Plasma 3-methoxy-4-hydroxyphenyglycol and homovanillic acid measurements in deficit and nondeficit forms of schizophrenia Biological Psychiatry 43 1998 24 30
35. P.H. Venables Input dysfunction in schizophrenia B.A. Maher Progress in Experimental Personality Research (I) 1964 Academic Press New York 1 47
36. M.C. Waldo, K. Graze, S. DeGraff Bender, L.E. Adler, and R. Freedman Premenstrual mood changes and gating of the auditory evoked potential Psychoneuroendocrinology 12 1987 35 40
37. M.C. Waldo, M. Carey, M. Myles-Worsley, E. Cawthra, L.E. Adler, H.T. Nagamoto, P. Wender, W. Byerley, R. Plaetke, and R. Freedman Codistribution of sensory gating deficit and schizophrenia in multi-affected families Psychiatry Research 39 1991 257 268
38. P.B. Ward, L.D. Hoffer, B.J. Liebert, S.V. Catts, M. O'Donnell, and L.E. Adler Replication of a P50 auditory gating deficit in Australian patients with schizophrenia Psychiatry Research 64 1996 121 135