Is P50 suppression a measure of sensory gating in schizophrenia?

Biological Psychiatry

Volumn 43, Issue 12, 1998, Pages 873-878

  Jin, Yi ^a   Bunney Jr, William E ^a   Sandman, Curt A ^a   Patterson, Julie V ^a   Fleming, Kirsten ^a   Moenter, Jeffrey R ^a   Kalali, Amir H ^a   Hetrick, William P ^a   Potkin, Steven G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

P50; Perceptual anomaly; Schizophrenia; Sensory gating

Indexed keywords

ADULT; ARTICLE; AUDITORY STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INFORMATION PROCESSING; MALE; PERCEPTION DISORDER; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSORY STIMULATION; VISUAL INFORMATION;

ACOUSTIC STIMULATION; ADULT; EVOKED POTENTIALS, AUDITORY; FEMALE; HALLUCINATIONS; HUMANS; MALE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; STARTLE REACTION;

EID: 0032526365     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00115-2     Document Type: Article

References (32)

1. Adler L.E., Pachtman E., Franks R.D., Pecevich M., Waldo M.C., Freedman R. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiatry. 17:1982;639-654.
2. Adler L.E., Waldo M.C., Freedman R. Neurophysiological studies of sensory gating in schizophrenia Comparison of auditory and visual responses . Biol Psychiatry. 17:1985;1284-1296.
3. Adler L.E., Pang K., Gerhardt G., Rose G.M. Modulation of the gating of auditory evoked potentials by norepinephrine Pharmacological evidence obtained using a selective neurotoxin . Biol Psychiatry. 24:1988;179-190.
4. Andreasen N.C., Arndt S., Swayze V. II, et al. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science. 266:1994;294-298.
5. Baker N.J., Adler L.E., Franks R.D., et al. Neurophysiological assessment of sensory gating in psychiatric inpatients Comparison between schizophrenia and other diagnoses . Biol Psychiatry. 22:1987;603-617.
6. Baker N.J., Staunton M., Adler L.E., et al. Sensory gating deficits in psychiatric inpatients Relation to catecholamine metabolites in different diagnostic groups . Biol Psychiatry. 27:1990;519-528.
7. Boutros N., Zouridakis G., Rustin T., Peabody C., Warder D. The p50 component of the auditory evoked potential and subtypes of schizophrenia. Psychiatry Res. 47:1993;243-254.
8. Braff D.L., Swerdlow N.R., Geyer M.A. Gating and habituation deficits in the schizophrenia disorders. Clin Neurosci. 3:1995;131-139.
9. Buchsbaum M.S., Someya T., Teng C.Y., et al. PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am J Psychiatry. 153:1996;191-199.
10. Cardenas V.A., Gersun J., Fein G. The reliability of P50 suppression as measured by the conditioning/testing ratio is vastly improved by dipole modeling. Biol Psychiatry. 33:1993;335-344.
11. Cullum C.M., Harris J.G., Waldo M.C., et al. Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia. Schizophr Res. 10:1993;131-141.
12. Eccles J.C. The Inhibitory Pathways of the Central Nervous System. 1969;University Press, Liverpool.
13. Franks R.D., Adler L.E., Waldo M.C., Pachtman E., Alpert J., Freedman R. Neurophysiological studies of sensory gating in mania Comparison with schizophrenia . Biol Psychiatry. 18:1983;989-1005.
14. Freedman R., Adler L.E., Waldo M.C., Pachtman E., Franks R.D. Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia Comparison of medicated and drug-free patients . Biol Psychiatry. 18:1983;537-551.
15. Freedman R., Adler L.E., Gerhardt G.A., et al. Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull. 13:1987;669-678.
16. Geyer M.A., Swerdlow N.R., Mansbach R.S., Braff D.L. Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull. 25:1990;485-498.
17. Hetrick W.P., Youssef M.M., Jin Y., et al. A structured clinical assessment of external sensory gating deficit in schizophrenia. Schizophr Res. 15:1995;177-178.
18. Hetrick W.P., Sandman C.A., Bunney W.E. Jr, Jin Y., Potkin S.G., White M.H. Gender differences in gating of the auditory evoked potential in normal subjects. Biol Psychiatry. 39:1996;51-58.
19. Jin Y., Potkin S.G. P50 changes with visual interference in normal subjects A sensory distortion model for schizophrenia . Clin Electroencephalogr. 27:1996;151-154.
20. Jin Y., Potkin S.G., Patterson J.V., Sandman C.A., Hetrick W.P., Bunney W.E. Jr. Effects of P50 temporal variability on sensory gating in schizophrenia. Psychiatry Res. 70:1997;71-81.
21. Judd L.L., McAdams L., Budnick B., Braff D.L. Sensory gating deficits in schizophrenia New results . Am J Psychiatry. 149:1992;488-493.
22. Kathmann N., Engel R.R. Sensory gating in normals and schizophrenics A failure to find strong P50 suppression in normals . Biol Psychiatry. 27:1990;1216-1226.
23. McGhie A., Chapman J. Disorders of attention and perception in early schizophrenia. Proc R Soc Med. 34:1961;103-116.
24. Nagamoto H.T., Adler L.E., Waldo M.C., Freedman R. Sensory gating in schizophrenic patients and normal controls Effects of changing stimulation interval . Biol Psychiatry. 25:1989;549-561.
25. Nuechterlein K.H., Dawson M.E. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull. 10:1985;160-203.
26. Schwarzkopf S.B., Lamberti J.S., Smith D.A. Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition. Biol Psychiatry. 33:1993;815-828.
27. Shagass C. Early evoked potentials. Schizophr Bull. 3:1977;80-90.
28. Siegel C., Waldo M.C., Minzer G., Adler L.E., Freedman R. Deficits in sensory gating in schizophrenia patients and their relatives. Arch Gen Psychiatry. 41:1984;607-612.
29. Venables P.H. Selectivity of attention in schizophrenia. Maher B.A. Progress in Experimental Personality Research. 1:1964;1-47 Academic Press, New York.
30. Waldo M.C., Freedman R. Gating of auditory evoked responses in normal college students. Psychiatry Res. 19:1986;233-239.
31. Waldo M.C., Carey G., Myles-Worsley M., et al. Codistribution of a sensory gating deficit and schizophrenia in multi-affected families. Psychiatry Res. 39:1991;257-268.
32. Weckowicz T.E., Blewett D.B. Size constancy and abstract thinking in schizophrenic patients. J Ment Sci. 105:1959;909-934.