Application of quantitative information on the uncertainty in the RfD to noncarcinogenic risk assessments

Human and Ecological Risk Assessment (HERA)

Volumn 5, Issue 3, 1999, Pages 527-546

  Carlson Lynch, Heather ^a   Price, Paul S ^b   Swartout, Jeffrey C ^c   Dourson, Michael L ^d   Keenan, Russell E ^b  

^a Ogden Environmental and Energy Services ^*  (United States)

^b Ogden Environmental and Energy Services   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d Toxicology Excellence for Risk Assessment   (United States)

Author keywords

Exposure; Mixtures; Monte Carlo; Noncancer risk assessment; Reference dose; Uncertainty; Variability

Indexed keywords

EID: 22644448984     PISSN: 10807039     EISSN: None     Source Type: Journal    
DOI: 10.1080/10807039.1999.10518877     Document Type: Article

References (32)

1. Baird, S.J.S., Cohen, J.T., Graham, J.D., Shlyakhter, A.I., and Evans, J.S. 1996. Noncancer risk assessment: Probabilistic characterization of population threshold doses. Human Ecol. Risk Assess. 2, 1, 79-102.
2. Barnes, D.G. and Dourson, M.L. 1988. Reference Dose (RfD): Description and use in health risk assessment. Regul. Toxicol. Pharmacol 8, 4, 471-486.
3. Bogen, K.T. 1995. Methods to appropriate joint uncertainty and variability in risk. Risk Anal. 15, 3, 411-419.
4. Finkel, A.M. 1990. Confronting Uncertainty in Risk Management: A Guide for Decision-Makers. Washington, DC, Resources for the Future.
5. Finley, B.L. and Paustenbach, D.J. 1994. The benefits of probabilistic exposure assessment: Three case studies involving contaminated air, water, and soil. Risk Anal. 14, 1, 53-73.
6. Frey, H.C. 1993. Separating variability and uncertainty in exposure assessment: Motivations and method. Presented at the 86th Annual Meeting of the Air and Waste Management Association, Denver, CO, June 13-18, 1993.
7. Gaylor, D.W. and Chen, J.J. 1996. A simple upper limit for the sum of the risks of the components in a mixture. Risk Anal. 16, 3, 395-398.
8. Hoffman, F. O. and Hammond, J. S. 1994. Propagation of uncertainty in risk assessments: The need to distinguish between uncertainty due to lack of knowledge and uncertainty due to variability. Risk Anal. 14, 5, 707-712.
9. McKone, T.E. and Bogen, K.T. 1992. Uncertainties in health risk assessment: An integrated case study based on tetrachloroethylene in groundwater. Regul. Toxicol. Pharmacol. 15, 1, 86-103.
10. MDEP (Massachusetts Department of Environmental Protection). 1996. The Massachusetts Contingency Plan. Bureau of Waste Site Cleanup, Boston, MA. 310 CMA 40.000. September.
11. Microsoft™ Corporation. 1994. Microsoft Excel Spreadsheet with Business Graphics and Database. Version 5.0, Palo Alto, CA.
12. 1 and making an appropriation from the Hazardous Discharge Bond Act of 1986.
13. Palisade Corporation. 1994. @Risk: Risk Analysis and Simulation Add-In for Microsoft Excel. Release 3.0, Newfield, NY.
14. Price, P.S., Sample, J., and Streiter, R. 1992. Determination of less-than-lifetime exposures to point source emissions. Risk Anal. 12, 3, 367-382.
15. Price, P.S., Su, S.H., Harrington, J.R., and Keenan, R.E. 1996. Uncertainty and variation in indirect exposure assessments: An analysis of exposure to tetrachlorodibenzo-p-dioxin from a beef consumption pathway. Risk Anal. 16, 2, 263-279.
16. Price, P., Keenan, R.E., Swartout, J.C., Gillis, C.A., Carlson-Lynch, H., and Dourson, M.L. 1997. An approach for modeling noncancer dose responses with an emphasis on uncertainty. Risk Anal. 17, 4, 427-437.
17. Putzrath, R.M. and Ginevan, M.E. 1991. Meta-analysis for combining data to improve quantitative risk analysis. Regul. Toxicol. Pharmacol. 14, 2, 178-188.
18. Putzrath, R.M. and Ginevan, M.E. 1994. Improving toxic equivalence factors (TEFs) for PCBs. Superfund XV Conference Proceedings, Washington, DC, November 29-December 1, 1994. Volume 2, pp. 1457-1463.
19. Renwick, A.G. and Walker, R. 1993. An analysis of the risk of exceeding the acceptable or tolerable daily intake. Regul. Toxicol. Pharmacol. 18, 3, 463-480.
20. a). Fund. Appl. Toxicol. (Suppl.), 36, 1, 208 (Abstract #1057).
21. Slob, W. and Pieters, M.N. 1997. A Probabilistic Approach for Deriving Acceptable Human Intake Limits and Human Health Risks from Toxicological Studies: General Framework. Rijksinstituut voor Volksgezondheid en Milieu, National Institute of Public Health and the Environment, The Netherlands. Report No. 620110005.
22. Stara, J.F., Bruins, R.J.F., Dourson, M.L., Erdreich, L.S., Hertzberg, R.C., Durking, P.R., and Pepelko, W. E. 1987. Risk assessment is a developing science: Approaches to improve evaluation of single chemicals and chemical mixtures. In: Methods for Assessing the Effects of Mixtures of Chemicals. (Vouk, V.B., Butler, G.C., Upton, A.C., Parke, D.V., and Asherr, S.C., Eds.).
23. Swartout, J. 1997. Exposure-duration uncertainty factor for the RfD. Fund. Appl. Toxicol. (Suppl.), 36, 1, 209 (Abstract #1060).
24. Swartout, J., Price, P., Dourson, M., Carlson-Lynch, H., and Keenan, R. 1998. A probabilistic framework for the reference dose. Risk Anal. (18)3.
25. Thompson, K.M., Burmaster, D.E., and Crouch, E.A.C. 1992. Monte Carlo techniques for quantitative uncertainty analysis in public health risk assessments. Risk Anal. 12, 1, 53-63.
26. USEPA (U.S. Environmental Protection Agency). 1986. Guidelines for the Health Risk Assessment of Chemical Mixtures. 51 FR 34014-34025.
27. USEPA (U.S. Environmental Protection Agency). 1988. Integrated Risk Information System (IRIS), Background Document 1. National Center for Environmental Assessment, Cincinnati, OH.
28. USEPA (U.S. Environmental Protection Agency). 1989. Risk Assessment Guidance for Superfund; Volume I: Human Health Evaluation Manual (Part A). Office of Emergency and Remedial Response, Washington, DC. EPA-540/1-89-002. Interim Final, July.
29. USEPA (U.S. Environmental Protection Agency). 1990. National Oil and Hazardous Substances Pollution Contingency Plan under the Comprehensive Environmental Response Compensation and Liability Act of 1980. 40 CFR 300.
30. USEPA (U.S. Environmental Protection Agency). 1992. Final Guidelines for Exposure Assessment; Notice. 57 Federal Register 104:22888-22938.
31. USEPA (U.S. Environmental Protection Agency). 1993. An SAB Report: Superfund Site Health Risk Assessment Guidelines. Review of the Office of Solid Waste and Emergency Responses Draft Risk Assessment Guidance for Superfund Human Health Evaluation Manual by the Environmental Health Committee. Science Advisory Board, Washington, DC. EPA-SAB-EHC-93-007. February.
32. USEPA (U.S. Environmental Protection Agency). 1995. Guidance for Risk Characterization. Science Policy Council, Washington, DC. February.