p62 protein is expressed in pancreatic β cells

Journal of Pathology

Volumn 206, Issue 4, 2005, Pages 402-408

  Lackner, Carolin ^a   Dlaska, Daniela ^a   Fuchsbichler, Andrea ^a   Stumptner, Cornelia ^a   Gogg Kamerer, Margit ^a   Zatloukal, Kurt ^a   Denk, Helmut ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

cell; Insulin; Neuroendocrine tumour; p62; Pancreas

Indexed keywords

CELL PROTEIN; CYTOPLASM PROTEIN; GLUCAGON; INSULIN; PROTEIN P62;

ALZHEIMER DISEASE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL INCLUSION; CELL PROLIFERATION; CHRONIC PANCREATITIS; CONTROLLED STUDY; DEGENERATIVE DISEASE; FATTY LIVER; GLUCAGONOMA; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INSULINOMA; MOUSE; NEUROENDOCRINE TUMOR; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS TUMOR; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SWINE; TUMOR CELL;

ANIMALS; ANTIBODIES, NEOPLASM; CARCINOMA, NEUROENDOCRINE; CHRONIC DISEASE; CROSS REACTIONS; FEMALE; GENE EXPRESSION; GLUCAGONOMA; HUMANS; IMMUNOHISTOCHEMISTRY; INSULINOMA; ISLETS OF LANGERHANS; MALE; MICE; PANCREATIC NEOPLASMS; PANCREATITIS; RNA-BINDING PROTEINS; SWINE;

EID: 22644432170     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1786     Document Type: Article

References (19)

1. Young HL, Jesang K, Joung I, Jung-Hye K, Jaekyoon S. Immediate early response of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein. FEBS Lett 1998; 438:297-300.
2. Geetha T, Wooten MW. Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett 2002; 512:19-24.
3. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 1996;70:1143-1153.
4. Joung I, Strominger JL, Shin J. Molecular cloning of a phosphotyrosine-independent ligand of the p56 lck SH2 domain. Proc Natl Acad Sci USA 1996;93:5991-5995.
5. Ishii T, Yanagawa T, Kawane T, Yuki K, Seita J, Yoshida H, Bannai S. Murine peritoneal macrophages induce a novel 60 kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. Biochem Biophys Res Commun 1996; 226:456-460.
6. Okazaki M, Ito S, Kawakita K, Takeshita S, Kawai S, Makishima F, et al. Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. Genomics 1999;60:87-95.
7. Puls A, Schmidt S, Grawe F, Stabel S. Interaction of protein kinase Cζ with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci USA 1997;94:6191-6196.
8. Pal S, Claffey KP, Dvorak HF, Mukhopadhyay D. The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J Biol Chem 1997;272:27 509-27 512.
9. Marcus SL, Winrow CJ, Capone JP, Rachubinski RA. A p56 (lck) ligand serves as a co-activator of an orphan nuclear hormone receptor. J Biol Chem 1996;271:27 197-27 200.
10. Rachubinski RA, Marcus SL, Capone JP. The p56(lck)-interacting protein p62 stimulates transcription via the SV40 enhancer. J Biol Chem 1999;274(26):18278-18284.
11. Stumptner C, Fuchsbichler A, Heid H, Zatloukal K, Denk H. Mallory body - a disease-associated type of sequestosome. Hepatology 2002;35:1053-1061.
12. Zatloukal K, Stumptner C, Fuchsbichler A, Heid H, Schnoelzer M, Kenner L, et al. P62 is a common component of cytoplasmic inclusions in protein aggregation diseases. Am J Pathol 2002; 160:255-263.
13. Kuusisto E, Salminen A, Alafuzoff I. Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies. NeuroReport 2001; 12:2085-2090.
14. Stumptner C, Heid H, Fuchsbichler A, Hauser H, Mischinger H-J, Zatloukal K, Denk H. Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma: demonstration of p62 as a major constituent. Am J Pathol 1999;154:1701-1710.
15. Nakano T, Nakaso K, Nakashima K, Ohama E. Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intra-neuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum. Acta Neuropathol 2004;107:359-364.
16. Zick Y. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol 2001; 11:437-441.
17. Leibiger IB, Leibiger B, Berggren P-O. Insulin feedback action on pancreatic β cell function. FEBS Lett 2002; 532:1-6.
18. Mandrup-Poulsen T. Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 2003;66:1433-1440.
19. Heitz PU, Komminoth P, Perren A, Klimstra DS, Dayal Y, Bordi C, et al. Tumours of the endocrine pancreas. In World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of Endocrine Organs, DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds). IARC Press: Lyon, 2004; 175-208.