Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory site

Molecular and Cellular Biology

Volumn 25, Issue 15, 2005, Pages 6314-6329

  Tcherkezian, Joseph ^a   Danek, Eric I ^a   Jenna, Sarah ^a   Triki, Ibtissem ^a   Lamarche Vane, Nathalie ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN CDC42; PROTEIN CDGAP; PROTEIN RHOGAP; RAC1 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; DNA CROSS LINKING; DOWNSTREAM PROCESSING; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; INVERTEBRATE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; TISSUE SPECIFICITY; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; FIBROBLASTS; GTPASE-ACTIVATING PROTEINS; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROLINE; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RAC1 GTP-BINDING PROTEIN; RAS PROTEINS; SIGNAL TRANSDUCTION;

INVERTEBRATA; MAMMALIA; VERTEBRATA;

EID: 22544479981     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.15.6314-6329.2005     Document Type: Article

References (38)

1. Ahmed, S., J. Lee, R. Kozma, A. Best, C. Monfries, and L. Lim. 1993. A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin. J. Biol. Chem. 268:10709-10712.
2. Bernards, A., and J. Settleman. 2004. GAP control: regulating the regulators of small GTPases. Trends Cell Biol. 14:377-385.
3. Boyle, W. J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:110-149.
4. Burridge, K., and K. Wennerberg. 2004. Rho and Rac take center stage. Cell 116:167-179.
5. Cerione, R. A., and Y. Zheng. 1996. The Db1 family of oncogenes. Curr. Opin. Cell Biol. 8:216-222.
6. Chiang, S. H., J. Hwang, M. Legendre, M. Zhang, A. Kimura, and A. R. Saltiel. 2003. TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 22:2679-2691.
7. Corbalan-Garcia, S., K. R. Degenhardt, and D. Bar-Sagi. 1996. Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. Oncogene 12:1063-5068.
8. Douville, E., and J. Downward. 1997. EOF induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene 15:373-383.
9. Erikson, R. L. 1991. Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6. J. Biol. Chem. 266:6007-6010.
10. Gonzalez, F. A., D. L. Raden, and R. J. Davis. 1991. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:22159-22163.
11. Hu, K. Q., and J. Settleman. 1997. Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J. 16:473-483.
12. Jacobs, D., D. Glossip, H. Xing, A. J. Muslin, and K. Kornfeld. 1999. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev. 13:163-175.
13. Jenna, S., N. K. Hussain, E. J. Danek, J. Triki, S. Wasiak, P. S. McPherson, and N. Lamarche-Vane. 2002. The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. J. Biol. Chem. 277:6366-6373.
14. Jenna, S., and N. Lamarche-Vane. 2003. The superfamily of Rho GTPase activating proteins, p. 68-87. In M. Symons (ed.). Rho GTPases. Kluwer Academic Press/Plenum Press, New York, N.Y.
15. Klemke, R. L., S. Cai, A. L. Giannini, P. J. Gallagher, P. de Lanerolle, and D. A. Cheresh. 1997. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137:481-492.
16. Kozma, R., S. Ahmed, A. Best, and L. Lim. 1996. The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol. Cell. Biol. 16:5069-5080.
17. Lamarche-Vane, N., and A. Hall. 1998. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. J. Biol. Chem. 273:29172-29177.
18. Li, X., E. Saint-Cyr-Proulx, K. Aktories, and N. Lamarche-Vane. 2002. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277:15207-15214.
19. Miki, H., M. Fukuda, E. Nishida, and T. Takenawa. 1999. Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J. Biol. Chem. 274:27605-27609.
20. Minoshima, Y., T. Kawashima, K. Hirose, Y. Tonozuka, A. Kawajiri, Y. C. Bao, X. Deng, M. Tatsuka, S. Narumiya, W. S. May, Jr., T. Nosaka, K. Semba, T. Inoue, T. Satoh, M. Inagaki, and T. Kitamura. 2003. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell 4:549-560.
21. Mitsushima, M., A. Suwa, T. Amachi, K. Ueda, and N. Kioka. 2004. Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. J. Biol. Chem. 279: 34570-34577,
22. Moon, S. Y., H. Zang, and Y. Zheng. 2003. Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP. J. Biol. Chem. 278: 4151-4159.
23. Moon, S. Y., and Y. Zheng. 2003. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13:13-22.
24. + exchanger in the rat myocardium by mitogen-activated protein kinase-dependent pathways. J. Biol. Chem. 274:22985-22992.
25. Moran, M. F., P. Polakis, F. McCormick, T. Pawson, and C. Ellis. 1991. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol. Cell. Biol. 11:1804-1812.
26. Nakamura, T., M. Komiya, K. Sone, E. Hirose, N. Gotoh, H. Morii, Y. Ohta, and N. Mori. 2002. Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Mol. Cell. Biol. 22:8721-8734.
27. Okabe, T., T. Nakamura, Y. N. Nishimura, K. Kohu, S. Ohwada, Y. Morishita, and T. Akiyama. 2003. RICS, a novel GTPase-activating protein for Cdc42 and Racl, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J. Biol. Chem. 278:9920-9927.
28. Olofsson, B. 1999. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal. 11:545-554.
29. 1. Science 269:1270-1272.
30. Peck, J., G. t. Douglas, C. H. Wu, and P. D. Burbelo. 2002. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. FEBS Lett. 528:27-34.
31. Roof, R. W., M. D. Haskell, B. D. Dukes, N. Sherman, M. Kinter, and S. J. Parsons. 1998. Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation. Mol. Cell. Biol. 18:7052-7063.
32. Sagnier, T., A. Grienenberger, M. Mariol, H. Berenger, J. Pradel, and Y. Graba. 2000. Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein. Mech. Dev. 94:267-270.
33. Songyang, Z., K. P. Lu, Y. T. Kwon, L. H. Tsai, O. Filhol, C. Cochet, D. A. Brickey, T. R. Soderling, C. Bartleson, D. J. Graves, A. J. DeMaggio, M. F. Hoekstra, J. Blenis, T. Hunter, and L. C. Cantley. 1996. A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II. NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16:6486-6493.
34. Su, L., J. M. Agati, and S. J. Parsons. 2003. p190RhoGAP is cell cycle regulated and affects cytokinesis. J. Cell Biol. 163:571-582.
35. Taniguchi, S., H. Liu, T. Nakazawa, K. Yokoyama, T. Tezuka, and T. Yamaraoto. 2003. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem. Biophys. Res. Commun. 306:151-155.
36. Van Aelst, L., and C. D'Souza-Schorey. 1997. Rho GTPases and signaling networks. Genes Dev. 11:2295-2322.
37. Woo, M. S., Y. Ohta, I. Rabinovitz, T. P. Stossel, and J. Blenis. 2004. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol. Cell. Biol. 24:3025-3035.
38. Zhao, C., H. Ma, E. Bossy-Wetzel, S. A. Lipton, Z. Zhang, and G. S. Feng. 2003. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J. Biol. Chem. 278:34641-34653.