Modelling and optimization of a recombinant BHK-21 cultivation process using hybrid grey-box systems

Journal of Biotechnology

Volumn 118, Issue 3, 2005, Pages 290-303

  Teixeira, A ^a   Cunha, A E ^b   Clemente, J J ^b   Moreira, J L ^b   Cruz, H J ^b   Alves, P M ^b   Carrondo, M J T ^a,b   Oliveira, R ^a  

^a DEPARTAMENTO DE QUÍMICA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

BHK 21 cell lines; Hybrid grey box modelling; IgG1 IL2 fusion protein; Process optimization

Indexed keywords

CELLS; CONCENTRATION (PROCESS); CONSTRAINT THEORY; COST EFFECTIVENESS; GLUCOSE; METABOLISM; OPTIMIZATION; PROTEINS; RISK ASSESSMENT;

CULTIVATION PROCESS; GLUTAMINE; GLYCOPROTEINS; GREY-BOX;

CELL CULTURE;

GLUCOSE; GLUTAMINE; GLYCOPROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G1; INTERLEUKIN 2;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL HYBRIDIZATION; CELL LINE; CELL METABOLISM; CELL STRAIN BHK; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CULTURE OPTIMIZATION; FED BATCH CULTURE; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROCESS MODEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RELIABILITY;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; COMPUTER SIMULATION; CRICETINAE; GENETIC ENHANCEMENT; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-2; KIDNEY; KINETICS; MODELS, BIOLOGICAL; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS;

MAMMALIA;

EID: 22544465571     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.04.024     Document Type: Article

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