Safety and immunogenicity of Salmonella enterica serovar Typhimurium llaB in mice

Journal of Microbiology and Biotechnology

Volumn 15, Issue 3, 2005, Pages 609-615

  Cho, Sun A ^c   Lee, In Soo ^a   Park, Jong Hwan ^c   Seok, Seung Hyeok ^c   Lee, Hui Young ^c   Kim, Dong Jae ^c   Back, Min Won ^c   Lee, Seok Ho ^b   Hur, Sook Jin ^b   Ban, Sang Ja ^b   Lee, Yoo Kyoung ^b   Park, Jae Hak ^c  

^a Hannam University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Attenuated recombinant Salmonella vaccine; Immunogenicity; S. enterica serovar Typhimurium llaB; Safety

Indexed keywords

BETA ACTIN; CONCANAVALIN A; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVE VACCINE; RECOMBINANT VACCINE; SALMONELLOSIS VACCINE; SODIUM CHLORIDE;

ACID TOLERANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE PROLIFERATION; MALE; MORTALITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA; SALMONELLOSIS; SPLEEN; SURVIVAL RATE; SURVIVAL TIME; VACCINATION; WILD TYPE;

SALMONELLA; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; TYPHIMURIUM;

EID: 22544465260     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Charfield, S., M. Roberts., P. London, I. Cropley, G. Douce, and G. Dougan. 1993. The development of oral vaccines based on live attenuated Salmonella strain. FEMS Immunol. Med. Microbiol. 7: 1-7.
2. Cookson, B. T. and M. J. Bevan. 1997. Identification of a natural T cell epitope presented by Salmonella infected macrophages and recognized by T cells from orally immunized mice. J. Immunol. 158: 4310-4319.
3. Ferreccio, C., M. M. Levine, H. Rodriguez, and R. Contreras. 1989. Comparative efficacy of two, three, or four doses of Ty21a live oral typhoid vaccine in enteric-coated capsule; a field trial in an endemic area. Infect Immun. 159: 766-769.
4. Foster, J. W. and B. Bearson. 1994. Acid-sensitive mutants of Salmonella typhimurium identification through a dinitrophenol lethal screening strategg. J. Bacteriol. 176: 2596-2602.
5. Gill, H. S., D. L. Watson, and M. R. Brandon. 1992. In vivo inhibition by monoclonal antibody to CD4+ T cells of Immoral and cellular immunity in sheep. Immunology 77: 38-42.
6. Hohmann, E. L., C. A. Oletta, K. P. Killeen, and S. I. Miller. 1996. phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers. J. Infect. Dis. 173: 1408-1414.
7. Holly, E. A. and W. Foster. 1982. Bacteriophage P22 as a vector for Mu mutagenesis in Salmonella typhimurium: Isolation of nad-lac and pnu-lac gene fusion. J. Bacteriol. 152: 959-962.
8. Hone, D. M., C. O. Tacket, A. M. Harris, B. Kay, G. Losonsky, and M. M. Levine. 1992. Evaluation in volunteers of a candidate live oral attenuated S. typhi vector vaccine. J. Clin. Invest. 90: 412-420.
9. Ivanoff, B., M. M. Levine, and P. H. Lambert. 1994. Vaccination against typhoid fever: Present status. Bull. World Health Organ. 72: 957-971.
10. Jonson, V. J., M. Tsunoda, and R. P. Sharma. 2000. Increased production of proinflammatory cytokines by murine macrophage following oral exposure to sodium selenite but not to seleno-L-methionine. Arch. Environ. Contam. Toxicol. 39: 243-250.
11. Kim, S. H., O. Y. Lim, S. H. Kim, J. Y. Kim, Y. H. Kang, and B. K. Lee. 2003. Pulsed-field gel electrophoresis and mutation typing of gyrA gene of quinolone-resistant Salmonella enterica serovar paratyphi a isolated from outbreak and sporadic cases, 1998-2002, Korea. J. Microbiol. Biotechnol. 13: 155-158.
12. Lee, H. Y., J. H. Park, S. H. Seok, S. A. Cho, M. W. Baek, D. J. Kim, Y. H. Lee, and J. H. Park. 2004. Dietary intake of various lactic acid bacteria suppresses Type 2 helper T cell production in antigen-primed mice splenocyte. J. Microbiol. Biotechnol. 14: 167-170.
13. Levine, M. M., D. Herrington, J. R. Murphy, J. G. Morris, G. Losonsky, B. Tall, A. A. Lindberg, S. Svenson, S. Baqar, and M. F. Edwards. 1987. Safety, infectivity, immunogenicity and in vivo ability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541Ty and 543Ty, as live oral vaccine in man. J. Clin. Invest. 79: 888-902.
14. Mosmann, T. R. and R. L. Coffman. 1989. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
15. Muotiala, A. and P. H. Makela. 1990. The role of INF-r in murine Salmonella typhimurium infection. Microb. Pathog. 8: 135-141.
16. Pang, T., M. M. Levine, B. Ivanoff, J. Wain, and B. B. Finlay. 1998. Typhoid fever - important issues still remain. Trends Microbiol. 6: 131-133.
17. Raupach, B. S. and H. Kaufmann. 2001. Bacterial virulence, proinflammatory cytokines and host immunity: How to choose the appropriate Salmonella vaccine strain? Microbes Infect. 3: 1261-1269.
18. Sebastiani, G., V. Blais, V. Sancho, S. N. Vogel, M. M. Stevenson, P. Gros, J. M. Lapointe, S. Rivest, and D. Malo. 2002. Host immune response to Salmonella enterica serovar typhimurium infection in mice derived from wild strains. Infect. Immun. 70: 1997-2009.
19. Sirard, J. C., F. Niedergang, and J. P. Kraehenbuhl. 1999. Live attenuated Salmonella: A paradigm of mucosal vaccines. Immunol. Rev. 171: 5-26.
20. Staats, H. F., R. J. Jackson, M. Marinaro, I. Takahashi, H. Kiyono, and J. R. McGhee. 1994. Mucosal immunity to infection with implication for vaccine development. Curr. Opin. Immunol. 6: 572-583.
21. Tacket, C. O., D. M. Hone, R. I. Curtiss, S. M. Kelly, G. Losonsky, L. Guers, A. M. Harris, R. Edelman, and M. M. Levine. 1992. Comparison of the safety and immunogenicity of aroCaroD and cya,crp Salmonella typhi strains in adult volunteers. Infect. Immun. 60: 536-541.
22. Tacket, C. O., M. B. Sztein, S. S. Wasserman, G. Losonsky, K. L. Kotloff, T. L. Wyant, J. P. Nataro, R. Edelman, J. Perry, P. Bedford, D. Brown, S. Chatfield, G. Dougan, and M. M. Levine. 2000. Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers. Infect. Immun. 68: 1196-1201.
23. Thatte, J., S. Rath, and V. Bal. 1995. Analysis of immunization route-related variations in the immune response to heat-killed Salmonella typhimurium in mice. Infect. Immun. 63: 99-103.
24. Wang, J. Y., M. F. Pasetti, F. R. Noriega, R. I. Anderson, S. S. Wasserman, J. E. Galen, M. B. Sztein, and M. M. Levine. 2001. Construction, genotyping and phenotyping characterization, and immunogenicity of attenuated ΔguaBA Salmonella enterica serovar typhi strain CDV 915. Infect. Immun. 69: 4734-4741.