Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

Journal of Natural Products

Volumn 68, Issue 6, 2005, Pages 853-857

  Appendino, Giovanni ^a   Aviello, Gabriella ^a   Ballero, Mauro ^b   Borrelli, Francesca ^a   Fattorusso, Ernesto ^c   Petrucci, Francesca ^c   Santelia, Federico U ^c   Taglialatela Scafati, Orazio ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 EPOXYGERMACRA EN 1,2,6 TRIOL; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; GERMACRANE DERIVATIVE; PLANT EXTRACT; SANTOLINA INSULARIS EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN CACO 2; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MEDICINAL PLANT; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SANTOLINA INSULARIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASTERACEAE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ITALY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANTS, MEDICINAL; SESQUITERPENES, GERMACRANE; STEREOISOMERISM;

SANTOLINA INSULARIS;

EID: 22544463616     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np050120q     Document Type: Article

References (19)

1. Baig, M. A.; Banthorpe, D. V.; Branch, S. A. Fitoterapia 1989, 60, 184-186.
2. Sala, A.; Recio, C.; Giner, R. M.; Manez, S.; Rios, J. Life Sci. 2000, 66, PL35-40.
3. Ballero, M.; Fresu, I. Fitoterapia 1991, 62, 524-531.
4. Fattorusso, E.; Santelia, F. U.; Appendino, G.; Ballero, M.; Taglialatela-Scafati, O. J. Nat. Prod. 2004, 67, 37-41.
5. Marco, J. A.; Sanz-Cervera, J. F.; Carda, M.; Lex, J. Photochemistry 1993, 34, 1549-1559.
6. Sanz, J. F.; Garcia-Sarrion, A.; Marco, J. A. Phytochemistry 1991, 30, 3339-3342.
7. Barrero, A. F.; Herrador, M. M.; Quilez, J. F.; Alvarez-Manzaneda, R.; Portal, D.; Gavin, J. A.; Gravalos, D. G.; Simmonds, M. S. J.; Blaney, W. M. Phytochemistry, 1999, 51, 529-541.
8. Appendino, G.; Gariboldi, P. J. Chem. Soc., Perkin Trans 1 1983, 2017-2026.
9. Crandall, J. K.; Apparu, M. Org. React. 1983, 29, 345-443.
10. Appendino, G.; Valle, M. G.; Gariboldi, P. J. Chem. Soc., Perkin Trans. 1 1986, 1363-1372.
11. Watson, W. H.; Kashyap, R. P. J. Org. Chem. 1986, 51, 2521-2524.
12. Bohlmann, F.; Umemoto, K.; Jakupovic, J.; King, R. M.; Robinson, H. Phytochemistry 1984, 23, 1800-1802.
13. Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J. Am. Chem. Soc. 1991 113, 4092-4096.
14. (a) Crouse, G. D. Chemtech 1998, November, 36-45.
15. (b) Kapitsky, S. V.; Zhukovskaya, M. I. Pheromones 1999, 6, 3-14.
16. Finn, R. D.; Jones, C. D. Nat. Prod. Rep. 2003, 20, 382-391.
17. (a) Kupchan, S. M.; Eakin, M. A.; Thomas, A. M. J. Med. Chem. 1971, 14, 1147-1152.
18. (b) Beekman, A. C.; Woerdenbag, H. J.; van Uden, W.; Pras, N.; Konings, A. W. T.; Wikstroem, H. V.; Schmidt, T. J. J. Nat. Prod. 1997, 60, 252-257.
19. (c) Schmidt, T. J.; Heilman, J. Quant. Struct.-Act. Relat. 2002, 21, 277-287.