The chemical speciation of uranium in water does not influence its absorption from the gastrointestinal tract of rats

Chemical Research in Toxicology

Volumn 18, Issue 7, 2005, Pages 1150-1154

  Frelon, S ^a   Houpert, P ^a   Lepetit, D ^a   Paquet, F ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE IRSN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

URANIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; COMPUTER MODEL; CONTROLLED STUDY; DOSIMETRY; EX VIVO STUDY; FECES LEVEL; FLUID INTAKE; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN VERSUS NONHUMAN DATA; IN VIVO STUDY; MALE; NONHUMAN; PH; RAT; SALIVA LEVEL; SPECIES DIFFERENTIATION; STOMACH JUICE; URINE LEVEL; VALIDATION PROCESS; WATER CONTAMINATION; WATER SAMPLING;

ANIMALS; GASTRIC JUICE; GASTROINTESTINAL TRACT; INTESTINAL ABSORPTION; IONS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SALIVA; URANIUM; WATER;

EID: 22544458453     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx049662i     Document Type: Article

References (30)

1. ICRP (2005) Human alimentary tract model for radiological protection. ICRP Publication 99, Annals of the ICRP, in press.
2. Houpert, P., Paquet, F., and Dublineau-Naud, I. (2001) Effect of external irradiation on the gastrointestinal absorption of uranium and neptunium in rats. Int. J. Radiat. Biol. 77, 383-388.
3. La Touche, Y. D., Willis, D. L., and Dawydiak, O. I. (1987) Absorption and biokinetics of uranium following an oral administration of uranyl nitrate solution. Health Phys. 53, 147-162.
4. Jonnalagadda, S. B. R. P. V. (1993) Toxicity, bioavailability and metal speciation. Comp. Biochem. Physiol., Part C: Pharmacol., Toxicol. Endocrinol. 106, 585-595.
5. Paquet, F., Frelon, S., Cote, G., and Madic, C. (2003) The contribution of chemical speciation to internal dosimetry. Radiat. Prot. Dosim. 105, 179-184.
6. Fortin, C., Dutel, L., and Garnier-Laplace, J. (2004) Uranium complexation and uptake by a green alga in relation to chemical speciation: The importance of the free uranyl ion. Environ. Toxicol. Chem. 23, 974-981.
7. Limson Zamora, M., Zielinski, J. M., Meyerhof, D., Moodie, G., Falcomer, R., and Tracy, B. (2003) Uranium gastrointestinal absorption: the f1 factor in humans. Radiat. Prot. Dosim. 105, 55-60.
8. Limson Zamora, M., Zielinski, J. M., Meyerhof, D. P., and Tracy, B. L. (2002) Gastrointestinal absorption of uranium in humans. Health Phys. 83, 35-45.
9. Markich, S. J. (2002) Uranium speciation and bioavailability in aquatic systems: An overview. Sci. World J. 2, 707-722.
10. Paquet, F., Frelon, S., Cote, G., and Madic, C. (2004) Speciation et dosimétrie interne-Des espèces chimiques aux modèles dosimétriques. Radioprotection 39, 341-354.
11. ICRP (1979) Limits for intakes of radionuclides by Workers. ICRP publication 30 Part 1. Annals of ICRP 2 (3/4), pp 102-104, Pergamon Press, Oxford.
12. Bradford, M. (1976) A rapid and sensitive method of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
13. Van der Lee, J., and De Windt, L. (2002) CHESS Tutorial and Cookbook/Version 3.0, Users Manual LHM/RD/02/13, Ecole des Mines de Paris, Fontainebleau.
14. Bierman, S. R., Clayton, E. D., Denning, R. G., Fuger, J., Güsten, H., Kanellakopulos, B., Rössler, K., Buschbeck, K. C., and Keller, C. (1983) Gmelin Handbook of Inorganic Chemistry, 8th ed., Supplement Volume A6, Springer-Verlag, Berlin.
15. Sutton, M., and Burastero, S. R. (2004) Uranium (VI) solubility and speciation in simulated elemental human biological fluids. Chem. Res. Toxicol. 17, 1468-1480.
16. Webb, L. M., Taylor, D. M., and Williams, D. R. (2002) Computer modeling of the chemical speciation of lanthanide and actinide elements in the human gastro-intestinal tract: Mouth and stomach. Radiat. Prot. Dosim. 79, 219-222.
17. Lepetit, D. (2002) Personal communication.
18. Tracy, B. L., Quinn, J. M., Lahey, J., Gilman, A. P., Mancuso, K., Yagminas, A. P., and Villeneuve, D. C. (1992) Absorption and retention of uranium from drinking water by rats and rabbits. Health Phys. 62, 65-73.
19. Harrison, J. D. (1991) The gastrointestinal absorption of the actinide elements. Sci. Total Environ. 100, 43-60.
20. Leggett, R. W., and Harrison, J. D. (1995) Fractional absorption of ingested uranium in humans. Health Phys. 68, 484-498.
21. Wrenn, M. E., Durbin, P. W., Howard, B., Lipsztein, J., Rundo, J., Still, E. T., and Willis, D. L. (1985) Metabolism of ingested U and Ra. Health Phys. 48, 601-633.
22. Harrison, J. D., and Stather, J. W. (1981) The gastrointestinal absorption of protactinium, uranium, and neptunium in the hamster. Radiat. Res. 88, 47-55.
23. Edgar, W. M. (1992) Saliva: its secretion, composition and functions. Br. Dent. J. 172, 305-312.
24. Gusman, H., Lendenmann, U., Grogan, J., Troxler, R. F., and Oppenheim, F. G. (2001) Is salivary histatin 5 a metallopeptide? Biochim. Biophys. Acta 1545, 86-95.
25. Humphrey, S. P., and Williamson, R. T. (2001) A review of saliva: Normal composition, flow and function. J. Prosthet. Dent. 85, 162-168.
26. Levine, M. J. (1993) Salivary macromolecules. A structure/function synopsis. Ann. N. Y. Acad. Sci. 694, 11-16.
27. Tunio, A. M., Whitfield, P. F., and Hobsley, M. (1997) Quantification of swallowed saliva in aspirated gastric juice. Eur. J. Gastroenterol. Hepatol. 9, 279-282.
28. Lentner, C. (1981) Geigy Scientific Tables, pp 113-133, Ciba-Geigy Limited, Basel.
29. Taylor, D. M., Duffield, D. R., and Proctor, S. A. (1985) The chemical forms of plutonium in the gastrointestinal tract. In Speciation of Fission and Activation Products in the Environment (Bulman, J. R., and Harrison, J. R., Eds.) pp 208-212, Elsevier Applied Science, London.
30. Yule, L., Quinn, D. M., Taylor, D. M., and Williams, D. R. (1992) Speciation of rarer metals in biological systems. Met. Compd. Environ. Life 4, 421-428.