Seizures in young dogs and cats: Pathophysiology and diagnosis

Compendium on Continuing Education for the Practicing Veterinarian

Volumn 27, Issue 6, 2005, Pages 447-460

  Coates, Joan R ^a   Bergman, Robert L ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b Carolina Veterinary Specialists   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS;

EID: 22544443037     PISSN: 01931903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (129)

1. Bunch SE: Anticonvulsant drug therapy in companion animals, in Kirk RW (ed): Current Veterinary Therapy IX. Philadelphia, WB Saunders, 1986, pp 836-844.
2. Cunningham JG, Farnbach GC: Inheritance and idiopathic canine epilepsy. JAAHA 24:421-424, 1988.
3. O'Brien D: Neurological examination and development of the neonatal dog. Semin Vet Med Surg Small Anim 9:62-67, 1994.
4. Kubova H, Moshe SL: Experimental models of epilepsy in young animals. J Child Neurol 9(suppl 1):S3-S11, 1994.
5. Sanchez RM, Jensen FE: Maturational aspects of epilepsy mechanisms and consequences for the immature brain. Epilepsia 42:577-585, 2001.
6. Holmes GL, Khazipov R, Ben Ari Y: New concepts in neonatal seizures. Neuroreport 13:A3-A8, 2002.
7. A channel subtypes. Mol Neurobiol 18:35-86, 1998.
8. Seress L, Frotscher M, Ribak CE: Local circuit neurons in both the dentate gyrus and Ammon's horn establish synaptic connections with principal neurons in five-day-old rats: A morphological basis for inhibition in early development. Exp Brain Res 78:1-9, 1989.
9. Seress L, Ribak CE: The development of GABAergic neurons in the rat hippocampal formation: An immunocytochemical study. Brain Res Dev Brain Res 44:197-209, 1988.
10. Kunkel DD, Hendrickson AE, Wu JY, Schwartzkroin PA: Glutamic acid decarboxylase (GAD) immunocytochemistry of developing rabbit hippocampus. J Neurosci 6:541-552, 1986.
11. Roberts E, Kuriyama K: Biochemical-physiological correlations in studies of the gamma-aminobutyric acid system. Brain Res 8:1-35, 1968.
12. A-receptor subtypes during postnatal development: An immunohistochemical study. J Neurosci 14:5302-5324, 1994.
13. Gaiarsa JL, McLean H, Congar P, et al: Postnatal maturation of gamma-aminobutyric acid A and B-mediated inhibition in the CA3 hippocampal region of the rat. J Neurobiol 26:339-349, 1995.
14. A receptors. Science 269:977-981, 1995.
15. Platt SR, McDonnell JJ: Status epilepticus: Patient management and pharmacologic therapy. Compend Contin Educ Pract Vet 22:722-729, 2000.
16. Young AB, Fagg GE: Excitatory amino acid receptors in the brain: Membrane binding and receptor autoradiographic approaches. Trends Pharmacol Sci 11:126-133, 1990.
17. Insel TR, Miller LP, Gelhard RE: The ontogeny of excitatory amino acid receptors in rat forebrain - I. N-methyl-D-aspartate and quisqualate receptors. Neuroscience 35:31-43, 1990.
18. Furuta A, Rothstein JD, Martin LJ: Glutamate transporter protein subtypes are expressed differentially during rat CNS development. J Neurosci 17:8363-8375, 1997.
19. 2+ changes during epileptiform discharges in the immature rat neocortex. Brain Res 433:299-303, 1987.
20. Eayrs JT, Goodhead B: Postnatal development of the cerebral cortex in the rat. J Anat 93:385-402, 1959.
21. Rennie JM: Neonatal seizures. Eur J Pediatr 156:83-87, 1997.
22. Vannucci RC, Fujikawa DG: Energy balance of the immature brain during status epilepticus, in Wasterlain CG, Vert P (eds): Neonatal Seizures. New York, Raven Press, 1990, pp 99-112.
23. Sacktor B, Wilson JE, Tiekert CG: Regulation of glycolysis in brain, in situ, during convulsions. J Biol Chem 241:5071-5075, 1966.
24. Young RS, Osbakken MD, Briggs RW, et al: 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog. Ann Neurol 18:14-20, 1985.
25. Marks JD, Bindokas VP, Zhang XM: Maturation of vulnerability to excitotoxicity: Intracellular mechanisms in cultured postnatal hippocampal neurons. Brain Res Dev Brain Res 124:101-116, 2000.
26. Marks JD, Friedman JE, Haddad GG: Vulnerability of CA1 neurons to glutamate is developmentally regulated. Brain Res Dev Brain Res 97:194-206, 1996.
27. Liu Z, Stafstrom CE, Sarkisian M, et al: Age-dependent effects of glutamate toxicity in the hippocampus. Brain Res Dev Brain Res 97:178-184, 1996.
28. McCabe BK, Silveira DC, Cilio MR, et al: Reduced neurogenesis after neonatal seizures. J Neurosci 21:2094-2103, 2001.
29. Moshe SL, Albala BJ: Kindling in developing rats: Persistence of seizures into adulthood. Brain Res 256:67-71, 1982.
30. Schmid R, Tandon P, Stafstrom CE, Holmes GL: Effects of neonatal seizures on subsequent seizure-induced brain injury. Neurology 53:1754-1761, 1999.
31. Liu Z, Yang Y, Silveira DC, et al: Consequences of recurrent seizures during early brain development. Neuroscience 92:1443-1454, 1999.
32. Montgomery DL, Lee AC: Brain damage in the epileptic beagle dog. Vet Pathol 20:160-169, 1983.
33. Martin E, Boesch C, Zuerrer M, et al: MR imaging of brain maturation in normal and developmentally handicapped children. J Comput Assist Tomogr 14:685-692, 1990.
34. Verity CM: Do seizures damage the brain? The epidemiological evidence. Arch Dis Child 78:78-84, 1998.
35. Commission on classification and terminology of the international league against epilepsy: Proposal for classification of epilepsies and epileptic syndromes. Epilepsia 26:268-278, 1985.
36. Jayakar P, Chiappa KH: Clinical correlations of photoparoxysmal responses. Electroencephalogr Clin Neurophysiol 75:251-254, 1990.
37. Nordli Jr DR, Kuroda MM, Hirsch LJ: The ontogeny of partial seizures in infants and young children. Epilepsia 42:986-990, 2001.
38. Volpe JJ: Neonatal seizures: Current concepts and revised classification. Pediatrics 84:422-428, 1989.
39. Tharp BR: Neonatal seizures and syndromes. Epilepsia 43(suppl 3):2-10, 2002.
40. Mizrahi EM, Kellaway P: Characterization and classification of neonatal seizures. Neurology 37:1837-1844, 1975.
41. Mizrahi EM: Neonatal seizures and neonatal epileptic syndromes. Neurologic Clinics 19:427-463, 2001.
42. Podell M, Fenner WR, Powers JD: Seizure classification in dogs from a nonreferral-based population. JAVMA 206:1721-1728, 1995.
43. March PA: Seizures: Classification, etiologies, and pathophysiology. Clin Tech Small Anim Pract 13:119-131, 1998.
44. Lorenz MD, Kornegay JN: Seizures, narcolepsy, and cataplexy, in Lorenz MD, Kornegay JN (eds): Handbook of Veterinary Neurology. St. Louis, Elsevier Science, 2004, pp 323-344.
45. Farnbach GC: Seizures in the dog. Part I: Basis, classification, and predilection. Compend Contin Educ Pract Vet 6:569-576, 1984.
46. Heynold Y, Faissler D, Steffen F, Jaggy A: Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 Labrador retrievers: A long-term study. J Small Anim Pract 38:7-14, 1997.
47. Berendt M, Gram L: Epilepsy and seizure classification in 63 dogs: A reappraisal of veterinary epilepsy terminology. J Vet Intern Med 13:14-20, 1999.
48. Knowles K: Seizure disorders in the pediatric animal patient. Semin Vet Med Surg Small Anim 9:108-115, 1994.
49. Thomas WB: Idiopathic epilepsy in dogs. Vet Clin North Am Small Anim Pract 30:183-206, vii, 2000.
50. Patterson EE, Mickelson JR, Da Y, et al: Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas. J Vet Intern Med 17:319-325, 2003.
51. Oliver JE, Lorenz MD, Kornegay JN: Handbook of Veterinary Neurology. Philadelphia, WB Saunders, 1997.
52. Podell M: Seizures in dogs. Vet Clin North Am Small Anim Pract 26:779-809, 1996.
53. Dewey CW: Encephalopathies: Disorders of the brain, in Dewey CW (ed): A Practical Guide to Canine and Feline Neurology. Ames, Iowa State University Press, 2003, pp 99-178.
54. Becker SV, Selby LA: Canine hydrocephalus. Compend Contin Educ Pract Vet 2:647-652, 1980.
55. Lu D, Lamb CR, Pfeiffer NE, Targett MP: Neurological signs and results of magnetic resonance imaging in 40 cavalier King Charles spaniels with Chiari type I-like malformations. Vet Rec 153:260-263, 2003.
56. Csiza CK, Scott FW, de Lahunta A, Gillespie JH: Pathogenesis of feline panleukopenia virus in susceptible newborn kittens, I: Clinical signs, hematology, serology, virology. Infect Immun 3:833-837, 1971.
57. Scott FW, de Lahunta A, Schultz RD, et al: Teratogenesis in cats associated with griseofulvin therapy. Teratology 11:79-86, 1975.
58. Summers BA, Cummings JF, de Lahunta A: Malformations of the central nervous system, in Summers BA, Cummings JF, de Lahunta A (eds): Veterinary Neuropatholgy. St. Louis, Mosby, 2000, pp 68-94.
59. Simpson ST: Hydrocephalus, in Kirk RW, Bonagura JD (eds): Current Veterinary Therapy X: Small Animal Practice. Philadelphia, WB Saunders, 1989, pp 842-847.
60. Hudson JA, Simpson ST, Buxton DF, et al: Ultrasonographic diagnosis of canine hydrocephalus. Vet Radial 31:50-58, 1990.
61. Klemm WR, Hall CL: Electroencephalograms of anesthetized dogs with hydrocephalus. Am J Vet Res 32:1859-1864, 1971.
62. th ACVIM Forum:891-893, 1994.
63. Gage ED, Hoerlein BF: Surgical treatment of canine hydrocephalus by verticuloatrial shunting. JAVMA 153:1418-1431, 1968.
64. Podell M, Shelton GD, Nyhan WL, et al: Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy. Metab Brain Dis 11:239-247, 1996.
65. Brenner O, de Lahunta A, Summers BA, et al: Hereditary polioencephalomyelopathy of the Australian cattle dog. Acta Neuropathol (Berl) 94:54-66, 1997.
66. Brenner O, Wakshlag JJ, Summers BA, de Lahunta A: Alaskan Husky encephalopathy: A canine neurodegenerative disorder resembling subacute necrotizing encephalomyelopathy (Leigh syndrome). Acta Neuropathol (Berl) 100:50-62, 2000.
67. Skelly BJ, Franklin RJM: Recognition and diagnosis of lysosomal storage diseases in the cat and dog. J Vet Intern Med 16:133-141, 2002.
68. Williams CE, Mallard C, Tan W, Gluckman PD: Pathophysiology of perinatal asphyxia. Clin Perinatal 20:305-325, 1993.
69. Gluckman PD, Pinal CS, Gunn AJ: Hypoxic-ischemic brain injury in the newborn: Pathophysiology and potential strategies for intervention. Semin Neonatol 6:109-120, 2001.
70. Yoshioka H, Nioka S, Miyake H, et al: Seizure susceptibility during recovery from hypercapnia in neonatal dogs. Pediatr Neural 15:36-40, 1996.
71. Howerton TL, Shell LG: Neurologic manifestations of altered serum glucose. Prog Vet Neural 3:57-64, 1992.
72. Hellmann J, Vannucci RC, Nardis EE: Blood-brain barrier permeability to lactic acid in the newborn dog: Lactate as a cerebral metabolic fuel. Pediatr Res 16:40-44, 1982.
73. Atkins CE: Disorders of glucose homeostasis in neonatal and juvenile dogs: Hypoglycemia (Part I). Compend Contin Educ Pract Vet 6:197-206, 1984.
74. van der Linde-Sipman JS, van den Ingh TS, van Toor AJ: Fatty liver syndrome in puppies. JAAHA 26:9-12, 1990.
75. Atkins CE: Disorders of glucose homeostasis in neonatal and juvenile dogs: Hypoglycemia (Part II). Compend Contin Educ Pract Vet 6:353-364, 1984.
76. Vannucci RC, Vannucci SJ: Hypoglycemic brain injury. Semin Neonatol 6:147-155, 2001.
77. Center SA, Magne ML: Historical, physical examination, and clinicopathologic features of portosystemic vascular anomalies in the dog and cat. Semin Vet Med Surg Small Anim 5:83-93, 1990.
78. Butler LM, Fossum TW, Boothe HW: Surgical management of extrahepatic portosystemic shunts in the dog and cat. Semin Vet Med Surg Small Anim 5:127-133, 1990.
79. Maddison JE: Hepatic encephalopathy: Current concepts of the pathogenesis. J Vet Intern Med 6:341-353, 1992.
80. Holt DE, Washabau RJ, Djali S, et al: Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts. Am J Vet Res 63:1167-1171, 2002.
81. McDonald JW, Silverstein FS, Johnston MV: Neurotoxicity of N-methyl-Daspartate is markedly enhanced in developing rat central nervous system. Brain Res 459:200-203, 1988.
82. Rothuizen J, van den Ingh TS, Voorhout G: Congenital portosystemic shunts in sixteen dogs and three cats. J Small Anim Pract 23:67-81, 1982.
83. Mathews K, Gofton N: Congenital extrahepatic portosystemic shunt occlusion in the dog: Gross observations during surgical correction. JAAHA 24:387-394, 1988.
84. Matushek KJ, Bjorling D, Mathews K: Generalized motor seizures after portosystemic shunt ligation in dogs: Five cases (1981-1988). JAVMA 196:2014-2017, 1990.
85. Hardie EM, Kornegay JN, Cullen JM: Status epilepticus after ligation of portosystemic shunts. Vet Surg 19:412-417, 1990.
86. Tisdall PL, Hunt GB, Youmans KR, Malik R: Neurological dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts. J Small Anim Pract 41:539-546, 2000.
87. Aronson LR, Gacad RC, Kaminsky-Russ K, et al: Endogenous benzodiazepine activity in the peripheral and portal blood of dogs with congenital portosystemic shunts. Vet Surg 26:189-194, 1997.
88. Tipold A: Diagnosis of inflammatory and infectious diseases of the central nervous system in dogs: A retrospective study. J Vet Intern Med 9:304-314, 1995.
89. Quesnel AD, Parent JM, McDonell W, et al: Diagnostic evaluation of cats with seizure disorders: 30 cases (1991-1993). JAVMA 210:65-71, 1997.
90. Thomas WB, Sorjonen DC, Steiss JE: A retrospective evaluation of 38 cases of canine distemper encephalomyelitis. JAAHA 29:129-133, 1993.
91. Cornwell HJ, Thompson H, McCandlish IA, et al: Encephalitis in dogs associated with a batch of canine distemper (Rockborn) vaccine. Vet Rec 122:54-59, 1988.
92. Murtaugh RJ, Fenner WR, Johnson GC: Focal granulomatous meningoencephalomyelitis in a pup. JAVMA 187:835-836, 1985.
93. Braund KG: Granulomatous meningoencephalomyelitis. JAVMA 186:138-141, 1985.
94. Cordy DR: Canine granulomatous meningoencephalomyelitis. Vet Pathol 16:325-333, 1979.
95. Ryan K, Marks SL, Kerwin SC: Granulomatous meningoencephalomyelitis in dogs. Compend Contin Educ Pract Vet 23:644-650, 2001.
96. Sorjonen DC: Clinical and histopathological features of granulomatous meningoencephalomyelitis in dogs. JAAHA 26:141-147, 1990.
97. Cordy DR, Holliday TA: A necrotizing meningoencephalitis of pug dogs. Vet Pathol 26:191-194, 1989.
98. Tipold A, Fatzer R, Jaggy A, et al: Necrotizing encephalitis in Yorkshire terriers. J Small Anim Pract 34:623-628, 1993.
99. Stalls IH, Chadwick B, Dayrell-Hart B, et al: Necrotizing meningoencephalitis of Maltese dogs. Vet Pathol 32:230-235, 1995.
100. Plummer SB, Wheeler SJ, Thrall DE, Kornegay JN: Computed tomography of primary inflammatory brain disorders in dogs and cats. Vet Radiol Ultrasound 33:307-312, 1992.
101. Smith-Maxie LL, Parent JP, Rand J, et al: Cerebrospinal fluid analysis and clinical outcome of eight dogs with eosinophilic meningoencephalomyelitis. J Vet Intern Med 3:167-174, 1989.
102. Bennett PF, Allan FJ, Guilford WG, et al: Idiopathic eosinophilic meningoencephalitis in rottweiler dogs: Three cases (1992-1997). Aust Vet J 75:786-789, 1997.
103. Schultze AE, Cribb AE, Tvedten HW: Eosinophilic meningoencephalitis in a cat. JAAHA 22:627, 1986.
104. Drobatz KJ, Concannon K: Noncardiogenic pulmonary edema. Compend Contin Educ Pract Vet 16:333-346, 1994.
105. th ACVIM Forum:361-364, 1990.
106. Boothe D, Peterson ME: Considerations in pediatric and geriatric poisoned patients, in Peterson ME, Talcott P (eds): Small Animal Toxicology, Philadelphia, WB Saunders, 2001, pp 114-127.
107. Hellmann J, Vannucci RC, Nardis EE: Blood-brain barrier permeability to lactic acid in the newborn dog: Lactate as a cerebral metabolic fuel. Pediatr Res 16:40-44, 1982.
108. O'Brien DP: Toxic and metabolic causes of seizures. Clin Tech Small Anim Pract 13:159-166, 1998.
109. Gerard VA, Conarck CN: Identifying the cause of an early onset of seizures in puppies with epileptic parents. Vet Med 1060-1061, 1991.
110. Wallace ME: Keeshonds: A genetic study of epilepsy and EEG readings. J Small Anim Pract 16:1-10, 1975.
111. Van der Velden NA: Fits in Tervueren shepherd dogs: A presumed hereditary trait. J Small Anim Pract 9:63-70, 1968.
112. Falco MJ, Barker J, Wallace ME: The genetics of epilepsy in the British Alsatian. J Small Anim Pract 15:685-692, 1974.
113. Jaggy A, Faissler D, Gaillard C, et al: Genetic aspects of idiopathic epilepsy in Labrador retrievers. J Small Anim Pract 39:275-280, 1998.
114. Srenk P, Jaggy A: Interictal electroencephalographic findings in a family of golden retrievers with idiopathic epilepsy. J Small Anim Pract 37:317-321, 1996.
115. Bielfelt SW, Redman HC, McClellan RO: Sire- and sex-related differences in rates of epileptiform seizures in a purebred beagle dog colony. Am J Vet Res 32:2039-2048, 1971.
116. Hall SJ, Wallace ME: Canine epilepsy: A genetic counselling programme for keeshonds. Vet Rec 138:358-360, 1996.
117. Famula TR, Oberbauer AM, Brown KN: Heritability of epileptic seizures in the Belgian Tervueren. J Small Anim Pract 38:349-352, 1997.
118. Famula TR, Oberbauer AM: Segregation analysis of epilepsy in the Belgian tervueren dog. Vet Rec 147:218-221, 2000.
119. Berkovic SF, Scheffer IE: Genetics of the epilepsies. Epilepsia 42(suppl 5):16-23, 2001.
120. Winkler JT, Bohling MW, Tillson DM, et al: Portosystemic shunts: Diagnosis, prognosis, and treatment of 64 cases (1993-2001). JAAHA 39:169-185, 2003.
121. Ozand PT, Gascon GG: Organic acidurias: A review. Part 1. J Child Neurol 6:196-219, 1991.
122. Ozand PT, Gascon GG: Organic acidurias: A review. Part 2. J Child Neurol 6:288-303, 1991.
123. Fenner WR: Central nervous system infections, in Greene CE (ed). Infectious Diseases of the Dog and Cat. Philadelphia, WB Saunders, 1998, pp 647-657.
124. Palmer DG, Huxtable CR, Thomas JB: Immunohistochemical demonstration of canine distemper virus antigen as an aid in the diagnosis of canine distemper encephalomyelitis. Res Vet Sci 49:177-181, 1990.
125. Rivers WJ, Walter PA: Hydrocephalus in the dog: Utility of ultrasonography as an alternate diagnostic imaging technique. JAAHA 28:333-343, 1992.
126. Saito M, Olby NJ, Spaulding KA: Identification of arachnoid cysts in the quadrigeminal cistern using ultrasonography. Vet Radiol Ultrasound 42:435-439, 2001.
127. Maytal J, Krauss JM, Novak G, et al: The role of brain computed tomography in evaluating children with new onset of seizures in the emergency department. Epilepsia 41:950-954, 2000.
128. Redding RW, Prynn RB, Wagner JL: Clinical use of the electroencephalogram in canine encephalitis. JAVMA 148:141-149, 1966.
129. Fox MW: Postnatal development of the EEG in the dog (part III). J Small Anim Pract 8:109-112, 1967.