Life-threatening hypercoagulable state following splenectomy in ITP: Successful management with aggressive antithrombotic therapy and danazol

Clinical and Applied Thrombosis/Hemostasis

Volumn 11, Issue 3, 2005, Pages 347-352

  Tiede, Maike P ^a   Ahn, Eugene R ^a   Jy, Wenche ^a   Scagnelli, Thomas ^a   Bidot, Carlos J ^a   Horstman, Lawrence L ^a   Jimenez, Joaquin J ^a   Ahn, Yeon S ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Danazol; Hypercoagulable state; Idiopathic thrombocytopenic purpura; Splenectomy

Indexed keywords

ANTICOAGULANT AGENT; DANAZOL; ENOXAPARIN; HEPARIN; IMMUNOGLOBULIN; STEROID;

ADULT; ANTICOAGULANT THERAPY; ARTICLE; BLOOD DONOR; CASE REPORT; DEEP VEIN THROMBOSIS; DISEASE COURSE; EMERGENCY TREATMENT; FIBRINOLYTIC THERAPY; GASTROINTESTINAL TUMOR; HEPARINIZATION; HUMAN; HYPERCOAGULABILITY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; LEG AMPUTATION; LUNG EMBOLISM; MALE; PRIORITY JOURNAL; PROCOAGULANT PLATELET MICROPARTICLE; RECURRENT DISEASE; REMISSION; SPLENECTOMY; STENT; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN;

BLOOD COAGULATION DISORDERS; DANAZOL; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SPLENECTOMY; THROMBOLYTIC THERAPY;

EID: 22544431632     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960501100316     Document Type: Article

References (16)

1. McMillan R. The pathogenesis of chronic immune (idiopathic) thrombocytopenic purpura. Semin Hematol 2000; 37:5.
2. Ahn YS, Horstman LL. Idiopathic thrombocytopenic purpura: Pathophysiology and management. Int J Hematol 2002;76:123.
3. Sims PJ, Wiedmer T. The response of human platelets to activated components of the complement system. Immunol Today 1991;12:338.
4. Bidot CJ, Jy W, Horstman LL, et al. Factor VII/VIIa: A new antigen in the antiphospholipid antibody syndrome. Br J Haematol 2003;120:618.
5. Jy W, Horstman LL, Park H, et al. Platelet aggregates as markers of platelet activation: Characterization of flow cytometric method suitable for clinical applications. Am J Hematol 1998;57:33.
6. Jy W, Horstman LL, Ahn YS, et al. Clinical significance of platelet microparticles in autoimmune thrombocytopenias. J Lab Clin Med 1992;119:334.
7. Ahn YS, Horstman LL, Jy W, et al. Vascular dementia in patients with immune thrombocytopenic purpura (ITP). Thromb Res 2003;107:337.
8. Ahn YS, Rocha R, Mylvaganam R, et al. Long-term danazol therapy in ITP. Unmaintained remissions and age dependent response in women. Ann Intern Med 1989;111: 723.
9. Kiefel V, Santoso S, Weisheit M, et al. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA). A new tool for the identification of platelet reactive antibodies. Blood 1987;70:1722.
10. Macchi L, Clofent-Sanches G, Marit G, et al. PAICA. A method for characterizing platelet-associated antibodies-its application to the study of idiopathic thrombocytopenic purpura and to the detection of platelet-bound c7E3. Thromb Hemost 1996;76:1020.
11. Robinette CD, Fraumeni Jr JF. Splenectomy and subsequent mortality in veterans of the 1936-1945 war. Lancet 1977;2:127.
12. Ozner MD, Ahn YS, Horstman LL, et al. Chronic platelet activation and acute coronary syndromes in 13 middle-aged patients. Clin Appl Thromb Hemost 1997;3:46.
13. Skarsgard E, Doski J, Jaksie T, et al. Thrombosis of the portal venous system after splenectomy for pediatric hematologic disease. J Pediatr Surg 1993;28:1109.
14. BaIz J, Minton JP. Mesenteric thrombosis following splenectomy. Ann Surg 1975;181:126.
15. Tai TT, Yu YL, Lau CP, et al. Myocardial infarction complicating post-splenectomy thrombocytosis, with early left ventricular mural thrombus formation and cerebral embolism: A case report. Angiology 1993;44:73.
16. Taylor SM, Reilly MP, Schreiber AD, et al. Thrombosis and shock induced by activating antiplatelet antibodies in human Fc gamma RIIA transgenic mice: The interplay among antibody, spleen, and Fc receptor. Blood 2000;96:4254.