Decrease of CD4+ T-lymphocytes in children exposed to environmental lead

Biological Trace Element Research

Volumn 105, Issue 1-3, 2005, Pages 19-25

  Li, Sun ^a   Zhengyan, Zhao ^a   Rong, L I ^a   Hanyun, Cheng ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Environmental lead exposure; Lymphocyte; Preschool children

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; LEAD;

ARTICLE; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; IMMUNE SYSTEM; IMMUNOTOXICITY; LEAD BLOOD LEVEL; LEAD POISONING; LYMPHOCYTE COUNT; MALE; NATURAL KILLER CELL; PERIPHERAL LYMPHOCYTE; PRESCHOOL CHILD;

ANTIGENS, CD19; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, CD56; ANTIGENS, CD8; B-LYMPHOCYTES; BODY HEIGHT; BODY WEIGHT; CD4-POSITIVE T-LYMPHOCYTES; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; IMMUNE SYSTEM; INFANT; KILLER CELLS, NATURAL; LEAD; LEAD POISONING; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MALE; RECEPTORS, IGG; SPECTROPHOTOMETRY, ATOMIC;

EID: 22444450466     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. T. L. Bunn, J. A. Marsh, and R. R. Dietert, Gender differences in developmental immunotoxicity to Pb in the chicken: analysis following a single early low-level exposure in ovo, J. Toxicol. Environ. Health 61, 101-117 (2000).
2. T. L. Bunn, P. J. Parsons, E. Kao, and R. R. Dietert, Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender, Toxicol Sci. 64, 57-66 (2001).
3. L. Sun, Z. Y. Zhao, and R. Li, Preschool children's lead levels in some rural communities of Zhejiang province, J. Improv. Birth Outcome Child Dev. China 1, 18-20 (2001).
4. P. M. Lutz, T. J. Wilson, and J. Ireland, Elevated immunoglobulin E levels in children with exposure to environmental lead, Toxicology 134, 63-78 (1999).
5. N. Basaran and U. Undeger, Effects of lead on immune parameters in occupationally exposed workers, Am. J. Ind. Med. 38, 349-354 (2000).
6. T. E. Miller, K. A. Golemboski, and R. S. Ha, Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats, Toxiclol. Sci. 42, 129-135 (1998).
7. F. Sata, S. M. Araki, and T. Tanigawa, Changes in T cell subpopulations in lead workers, Environ. Res. 76, 61-64 (1998).
8. B. Bishayi and M. Sengupta, Intracellular survival of Staphylococcus aureus due to alteration of cellular activity in arsenic and lead intoxicated mature Swiss albino mice, Toxicology 184(1), 31-39 (2003).
9. C. Teijon, R. Olmo, and M. Dolores Blanco, Effects of lead administration at low doses by different routes on rat spleens. Study of response of splenic lymphocytes and tissue lysozyme, Toxicology 191(2-3), 245-258 (2003).
10. Y. Heo and P. J. Parsons, Lead differentially modifies cytokine production in vitro and in vivo, Toxicol. Appl. Pharmacol. 138, 149-157 (1996).
11. U. Undeger, N. Basaran, H. Canponar, and E. Kansu, Immune alterations in lead-exposed workers, Toxicolology 109, 167-172 (1996).
12. P. Borella and A. Giardino, Lead and cadmium at very low doses affect in vitro immune response of human lymphocytes, Environ. Res. 55, 165-177 (1991).
13. M. Kern, M. Wisniewski, L. Cabell, and G. Audesirk, Inorganic lead and calcium interact positively in activation of calmodulin, Neurotoxicology 21(3), 353-363 (2000).
14. G. T. Ramesh and A. L. Jadhav, Levels of protein kinase C and nitric oxide synthase activity in rats exposed to sub chronic low level lead, Mol. Cell. Biochem. 223(1-2), 27-33 (2001).
15. N. Ercal, P. Treeratphan, P. Lutx, T. Hammond, and R. Matthews, N-Acetylcysteine protects Chinese hamster ovary (CHO) cell from lead induced oxidative stress, Toxicology 108, 57-64 (1996).
16. A. Fischbein, P. Tsang, and J.-C. J. Luo, Phenotypic aberrations of CD3+ and CD4+ cells and functional impairments of lymphocytes at low-level occupational exposure to lead, Clin. Immunol. Immunopathol. 66, 163-168 (1993).
17. G. C. Coscia, G. Discalzi, and C. Ponzetti, Immunological aspects of occupational lead exposure, Med. Lab. 78, 360 (1987).
18. K. P. Mishra, V. K. Singh, and R. Rani, Effect of lead exposure on the immune response of some occupationally exposed individuals, Toxicology 188(2-3), 251-259 (2003).