Magnolol induces apoptosis via alteration of Bax/Bcl-XL ratio and activation of caspases

Chinese Pharmacological Bulletin

Volumn 21, Issue 3, 2005, Pages 318-322

  Xia, Ming Yu ^a   Wang, Min Wei ^a   Tashiro, Shin Ichi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; HeLa cell; Magnolol

Indexed keywords

CASPASE; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; FAS ANTIBODY; MAGNOLOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL XL; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; PHASE CONTRAST MICROSCOPY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIME SERIES ANALYSIS; WESTERN BLOTTING;

EID: 22344457067     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Zhong WB, Wang CY, Ho KJ et al. Magnolol induces apoptosis in human leukemia cells via cytochrome C release and caspase activation[J]. Anticancer Drugs, 2003,14(3):211-7.
2. Lin SY, Chang YT, Liu JD et al. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells[J]. Mol Carcinog, 2001,32(2):73-83.
3. Takano F, Tanaka T, Tsukamoto W et al. Isolation of (+)-catenin and (-)-epicatenin from Actinidia arguta as bone marrow cell proliferation promoting compounds[J]. Planta Med, 2003,69(4): 321-6.
4. Suzuki K, Hino M , Kutsuna H et al. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β[J]. J Immunol, 2001,167(11):5940-7.
5. Thornberry NA, Lazebnik Y. Caspases: enemies within[J]. Science, 1998,281(8):1312-6.
6. Adams JM, Gory S. The Bcl-2 protein family: arbiters of cell survival [J]. Science, 1998,281(8):1322-6.
7. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene[J]. Cell, 1995,80(2):293-9.
8. Budihardjo I, Oliver H, Lutter M et al. Biochemical pathways of caspase activation during apoptosis[J]. Annu Rev Cell Dev Biol, 1999,15(1):269-90.
9. Chang HY, Yang XL. Proteases for cell suicide; functions and regulation of caspases[J]. Micro Mol Biol Rev, 2000,64(12): 821-46.
10. Korsmeyer SJ, Wei MC, Saito M et al. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c[J]. Cell Death Differ, 2000,7(12): 1166-73.
11. L, and Apaf-1 form a ternary complex[J]. J Biol Chem, 1998,273(3):5841-5.
12. L interacts with Apaf-1 and inhibits Apaf-1 -dependent caspase-9 activation[J]. Proc Natl Acad Sci, USA, 1998,95(4):4386-91.