Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties

Journal of Medicinal Chemistry

Volumn 48, Issue 14, 2005, Pages 4504-4506

  Parenty, Alexis D C ^a   Smith, Louise V ^a   Guthrie, Kevin M ^a   Long, De Liang ^a   Plumb, Jane ^b   Brown, Robert ^b   Cronin, Leroy ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXY 8 METHOXY 5 METHYL 2,3 METHYLENEDIOXYBENZO[C]PHENANTHRIDINIUM HYDROGEN SULFATE; BENZO[C]PHENANTHRIDINIUM; CARBOPLATIN; CHELERYTHRINE; DIHYDROPYRROLOPHENANTHRIDINIUM; DIOXOLOPHENANTHRIDINIUM; FAGARIDINE; FAGARONINE; INTERCALATING AGENT; NITIDINE; PHENANTHRIDINE DERIVATIVE; PYRROLOPHENANTHRIDINIUM; SANGUINARINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG HYDROLYSIS; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OVARY TUMOR; OXIDATION REDUCTION REACTION; REACTION ANALYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; INTERCALATING AGENTS; PHENANTHRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22244493849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050320z     Document Type: Article

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