-
1
-
-
0026572540
-
Recombinant GM-CSF/IL-3 fusion protein: Its effect on in vitro human megakaryocytopoiesis
-
E. Bruno, R.A. Briddell, R.J. Cooper, and R. Hoffman Recombinant GM-CSF/IL-3 fusion protein: its effect on in vitro human megakaryocytopoiesis Exp. Hematol. 20 1992 494 499
-
(1992)
Exp. Hematol.
, vol.20
, pp. 494-499
-
-
Bruno, E.1
Briddell, R.A.2
Cooper, R.J.3
Hoffman, R.4
-
2
-
-
0027755234
-
Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors
-
S. Grant, R. Traylor, and G.R. Pettit Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors Cytokine 5 1993 490 497
-
(1993)
Cytokine
, vol.5
, pp. 490-497
-
-
Grant, S.1
Traylor, R.2
Pettit, G.R.3
-
3
-
-
0030868182
-
Production of recombinant human GM-CSF-EPO hybrid proteins: In vitro biological characterization
-
A. Coscarella, C. Carloni, and R. Liddi Production of recombinant human GM-CSF-EPO hybrid proteins: in vitro biological characterization Eur. J. Haematol. 59 1997 238 246
-
(1997)
Eur. J. Haematol.
, vol.59
, pp. 238-246
-
-
Coscarella, A.1
Carloni, C.2
Liddi, R.3
-
4
-
-
0033810515
-
Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury
-
E. Galun, E. Zeira, and O. Pappo Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury FASEB J. 14 2000 1979 1987
-
(2000)
FASEB J.
, vol.14
, pp. 1979-1987
-
-
Galun, E.1
Zeira, E.2
Pappo, O.3
-
5
-
-
0035819764
-
Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3
-
T. Takizawa, M. Yanagisawa, and W. Ochiai Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 Cytokine 13 2001 272 279
-
(2001)
Cytokine
, vol.13
, pp. 272-279
-
-
Takizawa, T.1
Yanagisawa, M.2
Ochiai, W.3
-
6
-
-
5244233409
-
Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/ granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer
-
J.A. O'Shaughnessy, A. Tolcher, and D. Riseberg Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer Blood 87 1996 2205 2211
-
(1996)
Blood
, vol.87
, pp. 2205-2211
-
-
O'Shaughnessy, J.A.1
Tolcher, A.2
Riseberg, D.3
-
7
-
-
0033562815
-
Abrogation of the hematological and biological activities of the interleukin-3/granulocyte-macrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin
-
L.L. Miller, E.L. Korn, D.S. Stevens, and J.E. Janik Abrogation of the hematological and biological activities of the interleukin-3/granulocyte- macrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin Blood 93 1999 3250 3258
-
(1999)
Blood
, vol.93
, pp. 3250-3258
-
-
Miller, L.L.1
Korn, E.L.2
Stevens, D.S.3
Janik, J.E.4
-
8
-
-
0032885740
-
Randomized, double-blind, placebo-controlled trial to evaluate the hematopoietic growth factor PIXY321 after moderate-dose fluorouracil, doxorubicin, and cyclophosphamide in stage II and III breast cancer
-
S.E. Jones, P. Khandelwal, and K. McIntyre Randomized, double-blind, placebo-controlled trial to evaluate the hematopoietic growth factor PIXY321 after moderate-dose fluorouracil, doxorubicin, and cyclophosphamide in stage II and III breast cancer J. Clin. Oncol. 17 1999 3025 3032
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3025-3032
-
-
Jones, S.E.1
Khandelwal, P.2
McIntyre, K.3
-
9
-
-
0025346242
-
Use of recombinant human granulocyte-macrophage colony stimulating factors in graft failure after bone marrow transplantation
-
J. Neumunaitis, J.W. Singer, and C.D. Buckner Use of recombinant human granulocyte-macrophage colony stimulating factors in graft failure after bone marrow transplantation Blood 76 1990 245 253
-
(1990)
Blood
, vol.76
, pp. 245-253
-
-
Neumunaitis, J.1
Singer, J.W.2
Buckner, C.D.3
-
10
-
-
0025895274
-
Granulocyte-macrophage colony stimulating factors for the treatment of drug induced agranulocytosis
-
S. Nand, R. Bayer, and R.A. Prinz Granulocyte-macrophage colony stimulating factors for the treatment of drug induced agranulocytosis Am. J. Hematol. 37 1991 267 269
-
(1991)
Am. J. Hematol.
, vol.37
, pp. 267-269
-
-
Nand, S.1
Bayer, R.2
Prinz, R.A.3
-
11
-
-
0030792278
-
Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy: Correlation with clinical responses
-
C. Baxevanis, N. Tsavaris, and S. Papadhimitriou Granulocyte-macrophage colony-stimulating factor improves immunological parameters in patients with refractory solid tumours receiving second-line chemotherapy: correlation with clinical responses Eur. J. Cancer 33 1997 1202 1208
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 1202-1208
-
-
Baxevanis, C.1
Tsavaris, N.2
Papadhimitriou, S.3
-
12
-
-
10344242915
-
Randomized double-blind prospective trial to evaluate the effects of sargramostim versus placebo in a moderate-dose fluorouracil, doxorubicin, and cyclophosphamide adjuvant chemotherapy program for stage II and III breast cancer
-
S. Jones, M. Schottstaedt, and L. Duncan Randomized double-blind prospective trial to evaluate the effects of sargramostim versus placebo in a moderate-dose fluorouracil, doxorubicin, and cyclophosphamide adjuvant chemotherapy program for stage II and III breast cancer J. Clin. Oncol. 14 1996 2976 2983
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 2976-2983
-
-
Jones, S.1
Schottstaedt, M.2
Duncan, L.3
-
13
-
-
0033035045
-
Enhancement of hematopoietic reconstitution with recombinant cytokines: Effect of huIL-6 in combination with rhGM-CSF and rhIL-3 on unmodified or T cell-depleted bone marrow
-
M. Mumcuoglu, and S. Slavin Enhancement of hematopoietic reconstitution with recombinant cytokines: effect of huIL-6 in combination with rhGM-CSF and rhIL-3 on unmodified or T cell-depleted bone marrow J. Hematother. 8 1999 247 253
-
(1999)
J. Hematother.
, vol.8
, pp. 247-253
-
-
Mumcuoglu, M.1
Slavin, S.2
-
14
-
-
8544247201
-
A phase I study of interleukin-6 after autologous bone marrow transplantation for patients with poor prognosis Hodgkin's disease
-
K. Imrie, B. Sheridan, and R. Colwill A phase I study of interleukin-6 after autologous bone marrow transplantation for patients with poor prognosis Hodgkin's disease Leuk. Lymphoma 25 1997 555 563
-
(1997)
Leuk. Lymphoma
, vol.25
, pp. 555-563
-
-
Imrie, K.1
Sheridan, B.2
Colwill, R.3
-
15
-
-
0028961058
-
Thrombopoietic effects and toxicity of IL-6 in patients with ovarian cancel before and after chemotherapy: A multicentric placebo-controlled, randomized phase Ib study
-
V.D. Hondt, Y. Humblet, and T. Guillaume Thrombopoietic effects and toxicity of IL-6 in patients with ovarian cancel before and after chemotherapy: a multicentric placebo-controlled, randomized phase Ib study Blood 85 1995 2347 2353
-
(1995)
Blood
, vol.85
, pp. 2347-2353
-
-
Hondt, V.D.1
Humblet, Y.2
Guillaume, T.3
-
16
-
-
0029147155
-
Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer
-
G.J. Veldhuis, P.H. Willemse, and D.T. Sleijfer Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non-small-cell lung cancer J. Clin. Oncol. 13 1995 2585 2593
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 2585-2593
-
-
Veldhuis, G.J.1
Willemse, P.H.2
Sleijfer, D.T.3
-
17
-
-
0035135625
-
A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: Enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities
-
F. Bracho, M.D. Krailo, and V. Shen A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities Clin. Cancer Res. 7 2001 58 67
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 58-67
-
-
Bracho, F.1
Krailo, M.D.2
Shen, V.3
-
18
-
-
0029097954
-
Thrombocytopenia in dogs induced by granulocyte-macrophage colony-stimulating factor: Increased destruction of circulating platelets
-
R.A. Nash, S. Burstein, and R. Storb Thrombocytopenia in dogs induced by granulocyte-macrophage colony-stimulating factor: increased destruction of circulating platelets Blood 86 1995 1765 1775
-
(1995)
Blood
, vol.86
, pp. 1765-1775
-
-
Nash, R.A.1
Burstein, S.2
Storb, R.3
-
19
-
-
0024502002
-
Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF
-
D. Caracciolo, S.C. Clark, and G. Rovera Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF Blood 73 1989 666 670
-
(1989)
Blood
, vol.73
, pp. 666-670
-
-
Caracciolo, D.1
Clark, S.C.2
Rovera, G.3
-
20
-
-
0025736823
-
Interleukin-6 and interleukin-1 enhancement of GM-CSF-dependent proliferation of haematopoietic progenitor cells in myelodysplastic syndromes
-
M.R. Schipperus, P. Sonneveld, and J. Lindemans Interleukin-6 and interleukin-1 enhancement of GM-CSF-dependent proliferation of haematopoietic progenitor cells in myelodysplastic syndromes Br. J. Haematol. 77 1991 515 522
-
(1991)
Br. J. Haematol.
, vol.77
, pp. 515-522
-
-
Schipperus, M.R.1
Sonneveld, P.2
Lindemans, J.3
-
21
-
-
0026520373
-
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor
-
M.R. Walter, W.J. Cook, and S.E. Ealick Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor J. Mol. Biol. 224 1992 1075 1085
-
(1992)
J. Mol. Biol.
, vol.224
, pp. 1075-1085
-
-
Walter, M.R.1
Cook, W.J.2
Ealick, S.E.3
-
22
-
-
0024361204
-
Analysis of human IL-6 mutants expressed in E. coli: Biologic activities are not affected by deletions of amino acid 1-28
-
J.P. Brakenhoff, M. Hart, and L.A. Aarden Analysis of human IL-6 mutants expressed in E. coli: biologic activities are not affected by deletions of amino acid 1-28 J. Immunol. 143 1989 1175 1182
-
(1989)
J. Immunol.
, vol.143
, pp. 1175-1182
-
-
Brakenhoff, J.P.1
Hart, M.2
Aarden, L.A.3
-
23
-
-
0031913593
-
Interleukin 6 and its receptor: Ten years later
-
T. Hirano Interleukin 6 and its receptor: ten years later Int. Rev. Immunol. 16 1998 249 284
-
(1998)
Int. Rev. Immunol.
, vol.16
, pp. 249-284
-
-
Hirano, T.1
-
24
-
-
0021801341
-
Human GM-CSF: Molecular cloning of the complementary DNA and purification of the natural and recombinant proteins
-
G.G. Wong, J.S. Witek, and P.A. Temple Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins Science 228 1985 810 815
-
(1985)
Science
, vol.228
, pp. 810-815
-
-
Wong, G.G.1
Witek, J.S.2
Temple, P.A.3
-
25
-
-
0025264198
-
Granulocyte-macrophage colony stimulating factor from human lymphocytes. the effect of glycosylation on receptor binding and biological activity
-
J. Cebon, N. Nicola, and M. Ward Granulocyte-macrophage colony stimulating factor from human lymphocytes. The effect of glycosylation on receptor binding and biological activity J. Biol. Chem. 265 1990 4483 4491
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 4483-4491
-
-
Cebon, J.1
Nicola, N.2
Ward, M.3
-
26
-
-
0023840199
-
CDNA cloning of murine interleukin-HP1: Homology with human interleukin 6
-
S.J. Van, S. Cayphas, and J.P. Szikora cDNA cloning of murine interleukin-HP1: homology with human interleukin 6 Eur. J. Immunol. 18 1988 193 197
-
(1988)
Eur. J. Immunol.
, vol.18
, pp. 193-197
-
-
Van, S.J.1
Cayphas, S.2
Szikora, J.P.3
-
27
-
-
0025945651
-
Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein
-
B.M. Curtis, D.E. Williams, and H.E. Broxmeyer Enhanced hematopoietic activity of a human granulocyte/macrophage colony-stimulating factor-interleukin 3 fusion protein Proc. Natl. Acad. Sci. USA 88 1991 5809 5813
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 5809-5813
-
-
Curtis, B.M.1
Williams, D.E.2
Broxmeyer, H.E.3
-
28
-
-
0028274194
-
Mutagenesis of the human interleukin-6 fourth predicted alpha-helix: Involvement of the Arg168 in the binding site
-
V. Fontaine, J. Ooms, and J. Content Mutagenesis of the human interleukin-6 fourth predicted alpha-helix: involvement of the Arg168 in the binding site Eur. J. Immunol. 24 1994 1041 1045
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 1041-1045
-
-
Fontaine, V.1
Ooms, J.2
Content, J.3
-
29
-
-
0030029349
-
Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy
-
C. Nishimura, A. Watanabe, and H. Gouda Folding topologies of human interleukin-6 and its mutants as studied by NMR spectroscopy Biochemistry 35 1996 273 281
-
(1996)
Biochemistry
, vol.35
, pp. 273-281
-
-
Nishimura, C.1
Watanabe, A.2
Gouda, H.3
-
30
-
-
0028342979
-
Refolding proteins by gel filtration chromatography
-
M.H. Werner, G.M. Clore, and A.M. Gronenborn Refolding proteins by gel filtration chromatography FEBS Lett. 345 1994 125 130
-
(1994)
FEBS Lett.
, vol.345
, pp. 125-130
-
-
Werner, M.H.1
Clore, G.M.2
Gronenborn, A.M.3
|