A phase I study of interleukin-6 after autologous bone marrow transplantation for patients with poor prognosis Hodgkin's disease

Leukemia and Lymphoma

Volumn 25, Issue 5-6, 1997, Pages 555-563

  Imrie, K R ^a,b   Sheridan, B ^b   Colwill, R ^a   Crump, M ^a   Stewart, A K ^a   McCrae, J ^a   Danish, R ^a   Sutton, D ^a   Romeyer, F ^c   Keating, A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c Sandoz Canada   (Canada)

Author keywords

Autologous bone marrow transplantation; Hodgkin's disease; Interleukin 6; Phase I study; Poor prognosis

Indexed keywords

ACICLOVIR; ALKALINE PHOSPHATASE; CIPROFLOXACIN; ETOPOSIDE; GRANULOCYTE COLONY STIMULATING FACTOR; MELPHALAN; NYSTATIN; RECOMBINANT INTERLEUKIN 6;

ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG SAFETY; DRUG TOLERABILITY; FEVER; GASTROINTESTINAL TOXICITY; HEADACHE; HODGKIN DISEASE; HUMAN; MUCOSA INFLAMMATION; MYALGIA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTE TRANSFUSION;

EID: 8544247201     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199709039044     Document Type: Article

References (26)

1. Van Snick, J. (1990). Interleukin-6: an overview, Annual Review of Immunology, 8, 253-278.
2. Lotz, M (1993). Interleukin-6, Cancer Investigation. 11(6), 732-742.
3. Caracciolo, D., Clark, S. C. and Rovera, G (1989). Human interleukin-6 supports granulocytic differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF, Blood, 73, 666.
4. Ishibashi, T., Kimura, H., Uchida, T., Kariyone, S., Friese, P. and Burstein, S. A. (1989). Human Interleukin-6 is a direct promoter of maturation of megakaryocytes in vitro, Proceedings of the National Academy of Sciences, 86, 5953-5957.
5. Suda, T., Yamaguchi, Y., Suda, J., Miura, Y., Okano, A. and Akiyama, Y. (1988). Effect of Interleukin-6 on the differentiation and proliferation of murine and human hematopoietic progenitors. Experimental Hematology, 16, 891.
6. Ptachen, M. L., Macvittie, T. J., Williams, J. L., Schwatz, G. N. and Souza, L. M. (1991). Administration of Interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression, Blood. 77, 472-480.
7. Okano, A., Suzuki, C., Takatsuki, F. et al. (1989) Effects of Interleukin-6 on hematopoiesis in bone marrow transplanted mice. Transplantation, 47, 738
8. Givon, T. and Slavin, S. (1994). Potential use of Interleukin-6 after syngeneic and semiallogeneic bone marrow transplantation in mice, Blood, 83(6), 1690-1697.
9. Herodin, F., Mestries, J., Janodet, D. et al. (1992). Recombinant glycosylated human interleukin-6 accelerates peripheral blood platelet count recovery in radiation-induced bone marrow depression in baboons. Blood, 80(3), 688-695
10. Asano, S., Okano, A., Ozawa, K. et al. (1990). In vivo effects of recombinant human interleukin-6 in primates: stimulated production of platelets,. Blood, 75(8), 1602-1605.
11. Weber, J., Yang, J. C., Topalian, S. L. et al. (1993). Phase I trial of Subcutaneous Interleukin-6 in patients with advanced malignancies. Journal of Clinical Oncology. 11(3), 499-506.
12. Kishimoto, T. (1989). The biology of Interleukin-6, Blood, 74, 1-10
13. Mule, J. J., McIntosh, J. A. and Jablons, D. M. (1990). In vivo administration of recombinant Interleukin-6 mediates tumor regression in mice. Journal of Experimental Medicine. 171, 629-637.
14. Chen, L., Ziberstein, A. and Revel, M. (1988). Growth inhibition of breast carcinoma and leukemia/lymphoma cell lines by recombinant Interferon-B2, Proceedings of the National Academy of Sciences, 85, 8037-8041.
15. Shabo, Y., Lotem, J., Rubenstein, M. et al. (1988). The myeloid blood cell differentiation-inducing protein MGI-2A is Interleukin-6, Blood, 72, 2070-2073.
16. Goldstone, A. H. and McMillan, A. K. (1993). The place of high-dose therapy with hematopoietic stem cell transplantation in relapsed and refractory hodgkin's disease, Annals of Oncology, 4(SuppI 1), 21.
17. Crump, M., Smith, A., Brandwein, J. et al. (1993). High-dose etoposide and melphalan, autologous bone marrow transplantation for patients with advanced Hodgkin's disease: importance of disease status at transplant. Journal of Clinical Oncology. 11(4), 704-711.
18. Prince, H. M., Crump, M., Imrie, K. et al. (1996) Intensive therapy and autotransplant for patients with an incomplete response to front-line therapy for lymphoma. Annals, of Oncology, 7, 1043-1049.
19. Miller, A. B. (1981). WHO Toxicity Scale, Cancer. 47, 210.
20. Du, X. X and Williams, D. A. (1994). Interleukin-11: a multi-functional growth factor derived from the hematopoietic microenvironment. Blood. 83(8), 2023-2030.
21. Du, X. X., Doerschuk, C. M., Orazi, A. and Williams, D. A. (1994). Bone marrow stromal derived growth factor, Interleukin-11, stimulates recovery of small intestinal mucosal cells following cytoablative therapy, Blood, 83, 33.
22. Dofferhoff, A. S., Bom, V. J. and Van Ingen, J (1991). Patterns of cytokines, plasma endotoxin, and acute phase proteins during the treatment of severe sepsis in humans, Progress in Clinical and Biologic Research, 43, 367.
23. Hack, C. E., De Groot, E. R.. Felt-Bersma, R. J. et al. (1989). Increased plasma levels of lnterleukin-6 in sepsis. Blood, 74, 1704-1710.
24. Chasty, R. C., Lamb, W. R., Gallati, H., Roberts, T. E., Brenchley, P. E. and Yin, J. A. (1993). Serum cytokine levels in patients undergoing bone marrow transplantation, Bone Marrow Transplantation, 12(4), 331.
25. Kawano, Y., Takaue, Y., Saito, S. et al. (1993). Granulocyte colony stimulating factor (CSF), macrophage-CSF, granulocyte macrophage CSF, interleukin-3, and interleukin-6 levels in sera from patients undergoing blood stem cell autografts, Blood, 81, 856-860.
26. Baiocchi, G., Scambia, G., Benedetti, P. et al. (1993). Autologous stem cell transplantation: Sequential production of hematopoietic cytokines underlying granulocytic recovery, Cancer Research, 53, 1297-1303.