Italian multicentric pilot study on MBL2 genetic polymorphisms in HIV positive pregnant women and their children

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 17, Issue 4, 2005, Pages 253-256

  Crovella, Sergio ^a,b   Bernardon, Maria ^b   Braida, Laura ^a   Boniotto, Michele ^a,b   Guaschino, Secondo ^a   Ferrazzi, Enrico ^c   Martinelli, Pasquale ^d   Alberico, Salvatore ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d FEDERICO II UNIVERSITY HOSPITAL   (Italy)

Author keywords

Beta defensins; Genetic polymorphisms; HIV; Innate immunity; MBL2; Pregnancy

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; MANNOSE BINDING LECTIN;

ADULT; APGAR SCORE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DELIVERY; DISEASE TRANSMISSION; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; ITALY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MBL2 GENE; NEWBORN; PILOT STUDY; PREGNANCY; PRIORITY JOURNAL; SERODIAGNOSIS; TREATMENT OUTCOME; VERTICAL TRANSMISSION; VIRUS TRANSMISSION;

ADULT; COHORT STUDIES; DISEASE TRANSMISSION, VERTICAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, NATURAL; INFANT, NEWBORN; ITALY; MALE; MANNOSE-BINDING LECTIN; PILOT PROJECTS; POLYMORPHISM, GENETIC; PREGNANCY;

EID: 22244465907     PISSN: 14767058     EISSN: None     Source Type: Journal    
DOI: 10.1080/14767050500072599     Document Type: Article

References (8)

1. Boniotto M, Braida L, Pirulli D, et al. MBL2 polymorphisms are involved in HIV-1 infection in Brazilian perinatally infected children. AIDS 2003;17:779-780.
2. Amoroso A, Boniotto M, Crovella S, Serra C, Vatta S, Scarlatti G, Palomba E, Berrino M, Tovo PA. Polymorphism at codon 54 of Mannose binding protein gene influences AIDS progression but not HIV infection in exposed children. AIDS 1999;13:863-864.
3. Boniotto M, Crovella S, Pirulli D, Scarlatti G, Spanò A, Vatta L, Zezlina S, Tovo PA, Palomba E, Amoroso A. Polymorphisms in the MBL2 promoter correlated with risk of HIV-1 vertical transmission and AIDS progression. Genes and Immunity 2000;1(5):346-348.
4. Walsh PS, Metzger DA, Higuchi R. Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 1991;10:506-513.
5. Hladnik U, Braida L, Boniotto M, et al. Single-tube genotyping of MBL-2 polymorphisms using melting temperature analysis. Clin Exp Med 2002;2:105-108.
6. Garred P, Madsen HO, Balslev U, et al. Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin. Lancet 1997;349:236-240.
7. HIV-Infected Pregnant Women and Vertical Transmission in Europe since 1986 - European Collaborative Study. AIDS 2001;15:761.
8. Turner MW, Hamvas RM. Mannose-binding lectin: structure, function, genetics and disease associations. Rev Immunogenet 2000;2:305-322.