Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus

Annals of the New York Academy of Sciences

Volumn 1039, Issue , 2005, Pages 528-531

  Glasauer, Stefan ^a,b   Strupp, Michael ^a   Kalla, Roger ^a   Büttner, Ulrich ^a   Brandt, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cerebellum; Patient; Potassium channel blocker

Indexed keywords

4 AMINOPYRIDINE; POTASSIUM CHANNEL BLOCKING AGENT;

ADULT; AGED; CLINICAL ARTICLE; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EYE MOVEMENT; FEMALE; GAZE; HUMAN; MALE; NERVE CELL EXCITABILITY; NYSTAGMUS; PATHOGENESIS; POTASSIUM CURRENT; PURKINJE CELL; UPBEAT NYSTAGMUS;

EID: 22144480240     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1325.060     Document Type: Conference Paper

References (6)

1. STRUPP, M., O. SCHÜLER, S. KRAFCZYK, et al. 2003. Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study. Neurology 61: 165-170.
2. KALLA, R., S. GLASAUER, F. SCHAUTZER, et al. 2004. 4-aminopyridine improves downbeat nystagmus, smooth pursuit, and VOR gain. Neurology 62: 1228-1229.
3. GLASAUER, S., R. KALLA, U. BÜTTNER, et al. 2005. 4-aminopyridine restores visual ocular-motor function in upbeat nystagmus. J. Neurol. Neurosurg. Psychiatry 76: 451-453.
4. GLASAUER, S., M. HOSHI, U. KEMPERMANN, et al. 2003. Three-dimensional eye position and slow phase velocity in humans with downbeat nystagmus. J. Neurophysiol. 89: 338-354.
5. ETZION, Y. & Y. GROSSMAN. 2001. Highly 4-aminopyridine sensitive delayed rectifier current modulates the excitability of guinea pig cerebellar Purkinje cells. Exp. Brain Res. 139: 419-425.
6. MARTI, S., D. STRAUMANN & S. GLASAUER. 2005. The origin of downbeat nystagamus: an asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells. N.Y. Acad. Sci. 1039: 548-553.