N-terminal cleavage of proTGFα occurs at the cell surface by a TACE-independent activity

Biochemical Journal

Volumn 389, Issue 1, 2005, Pages 161-172

  Juanes, Pedro P ^a   Ferreira, Laura ^a   Montero, Juan Carlos ^a   Arribas, Joaquín ^b   Pandiella, Atanasio ^b  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Growth factor; Metalloprotease; N terminal shedding; Secretase; Transforming growth factor (TGF )

Indexed keywords

BIOLOGICAL MEMBRANES; ENZYME INHIBITION; GROWTH KINETICS; PROTEINS;

ENDOPLASMIC RETICULUM; GROWTH FACTORS; METALLOPROTEASES; PROTEOLYSIS;

CELLS;

BB 3103; METALLOPROTEINASE INHIBITOR; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA PROTEASE INHIBITOR 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MATURATION; CELL SURFACE; CHO CELL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADAM PROTEINS; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; HYDROXAMIC ACIDS; PROTEASE INHIBITORS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 22144479011     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041128     Document Type: Article

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