Orthodontically induced root and alveolar bone resorption: Inhibitory effect of systemic doxycycline administration in rats

European Journal of Orthodontics

Volumn 27, Issue 3, 2005, Pages 215-225

  Mavragani, Maria ^a,b   Brudvik, Pongsri ^b   Selvig, Knut Andreas ^a  

^a Department of Dental Research ^*  (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; DOXYCYCLINE; ISOENZYME; TARTRATE-RESISTANT ACID PHOSPHATASE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; INFUSION PUMP; INSTRUMENTATION; JAW; MALE; MOLAR TOOTH; MONONUCLEAR CELL; OSTEOCLAST; OSTEOLYSIS; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TOOTH DISEASE; TOOTH ROOT; WISTAR RAT;

ACID PHOSPHATASE; ALVEOLAR BONE LOSS; ALVEOLAR PROCESS; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; DOXYCYCLINE; INFUSION PUMPS; INJECTIONS, SUBCUTANEOUS; ISOENZYMES; LEUKOCYTES, MONONUCLEAR; MALE; MOLAR; OSTEOCLASTS; PERIODONTAL LIGAMENT; RATS; RATS, WISTAR; ROOT RESORPTION; TOOTH MOVEMENT; TOOTH ROOT;

EID: 22144474086     PISSN: 01415387     EISSN: None     Source Type: Journal    
DOI: 10.1093/ejo/cji015     Document Type: Article

References (70)

1. Al-Ali W, Bissada N F, Greenwell H 1989 The effect of local doxycycline with and without tricalcium phosphate on the regenerative healing potential of periodontal osseous defects in dogs. Journal of Periodontology 60: 582-590
2. Amin A R et al. 1996 A novel mechanism of action of tetracyclines: effects on nitric oxide syntheses. Proceedings of the National Academy of Sciences of the USA 93: 14014-14019
3. Ashcraft M B, Southard K A, Tolley E A 1992 The effect of corticosteroid-induced osteoporosis on orthodontic tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics 102: 310-319
4. Bain S, Ramamurthy N S, Impeduglia T, Scolman S, Golub L M, Rubin C 1997 Tetracycline prevents cancellous bone loss and maintains near-normal rates of bone formation in diabetic rats. Bone 21: 147-153
5. Bjorvatn K, Weiss M B 1971 Effect of topical application of fluoride, cortisone and tetracycline on reimplanted rat molars. FASETT 1: 27-31
6. 2 on root resorption in replanted incisors in dogs. Scandinavian Journal of Dental Research 97: 477-482
7. 2 on root resorption in rats. American Journal of Orthodontics and Dentofacial Orthopedics 109: 277-286
8. Brudvik P, Rygh P 1993a The initial phase of orthodontic root resorption incident to local compression of the periodontal ligament. European Journal of Orthodontics 15: 249-263
9. Brudvik P, Rygh P 1993b Non-clast cells start orthodontic root resorption in the periphery of hyalinized zones. European Journal of Orthodontics 15: 467-480
10. Brudvik P, Rygh P 1995a Transition and determinants of orthodontic root resorption-repair sequence. European Journal of Orthodontics 17: 177-188
11. Brudvik P, Rygh P 1995b The repair of orthodontic root resorption: an ultrastructural study. European Journal of Orthodontics 17: 189-198
12. Burns F R, Stack M S, Gray R D, Paterson C A 1989 Inhibition of purified collagenase from alkali-burned rabbit corneas. Investigative Ophthalmology and Visual Science 30: 1569-1575
13. Caton J G et al. 2000 Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. Journal of Periodontology 71: 521-532
14. Chambers T J, McSheehy P M, Thomson B M, Fuller K 1985 The effect of calcium regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology 116: 234-239
15. Ciancio S, Ashley R 1998 Safety and efficacy of sub-antimicrobial-dose doxycycline therapy in patients with adult periodontitis. Advances in Dental Research 12: 27-31
16. Cvek M, Cleaton-Jones P, Austin J, Kling M, Lownie J, Fatti P 1990 Effect of topical application of doxycyline on pulp revascularization and periodontal healing in reimplanted monkey incisors. Endodontics and Dental Traumatology 6: 170-176
17. Davidovitch Z 1991 Tooth movement. Critical Reviews in Oral Biology and Medicine 2: 411-450
18. Forsgren A, Schmeling D, Quie P G 1974 Effect of tetracycline on the phagocytic function of human leukocytes. Journal of Infectious Diseases 130: 412-415
19. Gabler W L, Creamer H R 1991 Suppression of human neutrophil functions by tetracyclines. Journal of Periodontal Research 26: 52-58
20. Golub L M et al. 1983 Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of action. Journal of Periodontal Research 18: 516-526
21. Golub L M et al. 1984 Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease. Journal of Periodontal Research 19: 651-655
22. Golub L M et al. 1985 Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources. Journal of Periodontal Research 20: 12-23
23. Golub L M, McNamara T F, D'Angelo G, Greenwald R A, Ramamurthy N S 1987 A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. Journal of Dental Research 66: 1310-1314
24. Golub L M, Ciancio S, Ramamurthy N S, Leung M, McNamara T F 1990a Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans. Journal of Periodontal Research 25: 321-330
25. Golub L M, Ramamurthy N S, Kaneko H, Sasaki T, Rifkin B, McNamara T F 1990b Tetracycline administration prevents diabetes-induced osteopenia in the rat: initial observations. Research Communications in Chemical Pathology and Pharmacology 68: 27-40
26. Golub L M, Wolff M, Roberts S, Lee H M, Leung M, Payonk G S 1994 Treating periodontal diseases by blocking tissue-destructive enzymes. Journal of the American Dental Association 125: 163-169
27. Golub L M, Lee H M, Ryan M E, Giannobile W V, Payne J, Sorsa T 1998 Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Advances in Dental Research 12: 12-26
28. Greenwald R A, Golub L M, Ramamurthy N S, Chowdhury M, Moak S A, Sorsa T 1998 In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone 22: 33-38
29. Grevstad H J 1993 Doxycycline prevents root resorption and alveolar bone loss in rats after periodontal surgery. Scandinavian Journal of Dental Research 101: 287-291
30. Grevstad H J, Bøe O E 1995 Effect of doxycycline on surgically induced osteoclast recruitment in the rat. European Journal of Oral Sciences 103: 156-159
31. Harris E D, Welgus H G, Krane S M 1984 Regulation of the mammalian collagenases. Collagen and Related Research: Clinical and Experimental 4: 493-499
32. Igarashi K, Mitani H, Adachi H, Shinoda H 1994 Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics 106: 279-289
33. Igarahsi K, Adachi H, Mitani H, Shinoda H 1996 Inhibitory effect of the topical administration of a bisphosphonate (Risedronate) on root resorption incident to orthodontic tooth movement in rats. Journal of Dental Research 75: 1644-1649
34. Konttinen Y T et al. 1998 New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above. Matrix Biology 17: 585-601
35. Kvam E 1973 Organic tissue characteristic on the pressure side of human premolars following tooth movement. Angle Orthodontist 43: 18-23
36. Leiker B J, Nanda R S, Currier G F, Hower R I, Sinha P K 1995 The effects of exogenous prostaglandins on orthodontic tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics 108: 380-388
37. Loberg E, Engström C 1994 Thyroid administration to reduce root resorption. Angle Orthodontist 64: 395-399
38. Martin R R, Warr G A, Couch R B, Yeager H, Knight V 1974 Effects of tetracycline on leukotaxis. Journal of Infectious Diseases 129: 110-117
39. Mavragani M, Amundsen O C, Selliseth N J, Brudvik P, Selvig K A 2004 Early root alterations after orthodontic force application studied by light and scanning electron microscopy. European Journal of Orthodontics 26: 119-128
40. McGuire A, Moonga B, Rifkin B 1998 Tetracyclines promote osteoclast apoptosis. Journal of Dental Research 77: 722 (abstract)
41. Ong C K L, Walsh L J, Harbrow D, Taverne A A R, Symons A L 2000 Orthodontic tooth movement in the prednisolone-treated rat. Angle Orthodontist 70: 118-125
42. Parfitt A M et al. 1987 Bone histomorphometry: standarization of nomenclature, symbols, and units. Journal of Bone and Mineral Research 2: 595-610
43. Poumpros E, Loberg E, Engström C 1994 Thyroid function and root resorption. Angle Orthodontist 64: 389-394
44. 2 by minocycline and doxycycline. Biochemical Pharmacology 44: 1165-1170
45. Ramamurthy N S et al. 1990 The effect of tetracyclines on collagenase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. Research Communications in Chemical Pathology and Pharmacology 70: 323-325
46. Ramamurthy N S et al. 1998 Root-surface caries in rats and humans: inhibition by a non-antimicrobial property of tetracyclines. Advances in Dental Research 12: 43-50
47. Reitan K 1951 The initial tissue reaction incident to orthodontic tooth movement. Acta Odontologica Scandinavica 9: Supplement 6
48. Rifkin B R et al. 1992 Effects of tetracyclines on rat osteoblast collagenase activity and bone resorption in vitro. In: Davidovitch Z (ed.) The biological mechanisms of tooth movement and craniofacial adaptation. EBSCO Media, Birmingham, Alabama, pp. 85-90
49. Rifkin B R, Vernillo A T, Golub L M 1993 Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. Journal of Periodontology 64: 819-827
50. Rifkin B R, Vernillo A T, Golub L M, Ramamurthy N S 1994 Modulation of bone resorption by tetracyclines. Annals of the New York Academy of Sciences 732: 165-180
51. Rifkin B R, Golub L M, Ramamurthy N S, Vernillo A T 1996 Inhibition of bone resorption by tetracyclines. In: Davidovitch Z (ed.) Biological mechanisms of tooth movement and craniofacial adaptation. Harvard Society for the Advancement of Orthodontics, Boston, pp. 357-363
52. Rygh P 1977 Orthodontic root resorption studied by electron microscopy. Angle Orthodontist 47: 1-16
53. Saito M, Saito S, Ngan P W, Shanfeld J, Davidovich Z 1991 Interleukin 1 beta and prostaglandin E are involved in the response of periodontal cells to mechanical stress in vivo and in vitro. American Journal of Orthodontics and Dentofacial Orthopedics 99: 226-240
54. Sasaki T, Kaneko H, Ramammthy N S, Golub L M 1991 Tetracycline administration restores osteoblast structure and function during experimental diabetes. Anatomical Record 231: 25-34
55. Sasaki T, Ramamurthy N S, Golub L M 1992 Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats: a quantitative autoradiographic study. Calcified Tissue International 50: 411-419
56. Schroeder K L, Lee H, Wolff M, Ramamurthy N, Golub L 1990 Low-dose tetracyclines (TCs) decrease elastase and B-glucuronidase activities in gingival crevicular fluid. Journal of Dental Research 69: 245 (abstract)
57. Schroeder K L et al. 1992 Low-dose doxycycline (LDD) prevents attachment loss in adult periodontitis. Journal of Dental Research 72: 758 (abstract)
58. 2 and calcium gluconate on orthodontic tooth movement and root resorption in rats. European Journal of Orthodontics 25: 199-204
59. Selvig K A, Bjorvatn K, Bogle G C, Wikesjö U M E 1992 Effect of stannous fluoride and tctracycline on periodontal repair after delayed tooth replantation in dogs. Scandinavian Journal of Dental Research 100: 200-203
60. Shapira L, Soskolne W A, Houri Y, Barak V, Halabi A, Stabholz A 1996 Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion. Infection and Immunity 64: 825-828
61. Shirazi M, Dehpour A R, Jafari F 1999 The effect of thyroid hormone on orthodontic tooth movement in rats. Journal of Clinical Pediatric Dentistry 23: 259-264
62. Skidmore R et al. 2003 Effects of subantimicrobial-dose doxycycline in the treatment of moderate acne. Archives of Dermatology 139: 459-464
63. Smith D A, Burgman P M 1997 Formulary. In: Hillyer E V, Quesenberry K E (eds) Ferrets, rabbits and rodents. Clinical medicine and surgery. W.B. Saunders, Philadelphia, p. 400
64. Thomas J et al. 1995 Antibiotic resistance evaluation with low-dose doxycycline (LDD) in adult periodontitis. Journal of Dental Research 74: 575 (abstract)
65. Thomas J, Walker C, Bradshaw M 2000 Long-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibility. Journal of Periodontology 71: 1472-1483
66. Vernillo A T, Rifkin B R 1998 Effects of tetracyclines on bone metabolism. Advances in Dental Research 12: 56-62
67. Vernillo A T, Ramamurthy N S, Golub L M, Rifkin B R 1994 The nonantimicrobial properties of tetracycline for the treatment of periodontal disease. Current Opinion in Periodontology 2: 111-118
68. Williams S et al. 1996 Minocycline prevents the decrease in bone mineral density and trabecular bone in ovariectomized aged rats. Bone 19: 637-644
69. Yamasaki K 1983 The role of cyclic AMP, calcium, and prostaglandins in the induction of osteoclastic bone resorption associated with experimental tooth movement. Journal of Dental Research 62: 877-881
70. Yanagimura M, Koike F, Hara K 1989 Collagenase activity in gingival crevicular fluid and inhibition by tetracyclines. Journal of Dental Research 68: 1691-1693