Pharmacokinetics and pharmacodynamics of pantoprazole in clinically normal neonatal foals

Equine Veterinary Journal

Volumn 37, Issue 4, 2005, Pages 336-341

  Ryan, C A ^a   Sanchez, L C ^a   Giguere S ^a   Vickroy, T ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida   (United States)

Author keywords

Foal; Gastric ulceration; Horse; Pantoprazole; Proton pump inhibitor

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

EID: 22144450336     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/0425164054529427     Document Type: Conference Paper

References (27)

1. Andrews, F.M., Bernard, W.V., Byars, T.D., Cohen, N.D., Divers, T.J., MacAllister, C.G., McGladdery, A., Merritt, A.M., Murray, M.J., Orsini, J.A., Snyder, J.R. and Vatistas, N.J. (1999a) Recommendations for the diagnosis and treatment of equine gastric ulcer syndrome (ECUS). Equine vet. Educ. 1, 122-134.
2. Andrews, P.M., Sifferman, R.L., Bernard, W., Hughes, P.E., Holste, J.E., Daurio, C.P., Alva, R. and Cox, J.L. (1999b) Efficacy of omeprazole paste in the treatment and prevention of gastric ulcers in horses. Equine vet. J., Suppl. 29, 81-86.
3. Andrews, P.M., Doherty, T.J., Blackford, J.T., Nadeau, J.A. and Saxton, A.M. (1999c) Effects of orally administered enteric-coated omeprazole on gastric acid secretion in horses. Am. J. vet. Res. 60, 929-931.
4. Anon (2002) Pantoprazole IV (Protonix IV). Med. Lett. Drugs Ther. 44, 41-42.
5. Brzozowski, T., Konturek, P.C., Konturek, S.J., Drozdowicz, D., Kwiecien, S., Pajdo, R., Bielanski, W. and Hahn, E.G. (2000) Role of gastric acid secretion in progression of acute gastric erosions induced by ischaemia-reperfusion into gastric ulcers. Eur. J. Pharmacol. 398, 147-158.
6. Burget, D.W., Chiverton, S.G. and Hunt, R.H. (1990) Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterol. 99, 345-351.
7. Daurio, C.P., Holste, I.E., Andrews, P.M., Merritt, A.M., Blackford, J.T., Dolz, F. and Thompson, D.R. (1999) Effect of omeprazole paste on gastric acid secretion in horses. Equine vet. J., Suppl. 29, 59-62.
8. Gibaldi, M. and Perrier, D. (1982) Pharmacokinetics, Marcel Dekker, New York.
9. Hammond, C.J. (1990) A study of gastric mucosal pH and its correlation with gastric ulcers in adult horses. J. equine vet. Sci. 10, 404-408.
10. Huang, J.Q. and Hunt, R.H. (2001) Pharmacological and pharmacodynamic essentials of H(2)-receptor antagonists and proton pump inhibitors for the practising physician. Best Pract. Res. Clin. Gastroenterol. 15, 355-370.
11. MacAllister, C.G., Sifferman, R.L., McClure, S.R., White, G.W., Vatistas, N.J., Holste, J.E., Ericcson, G.F. and Cox, J.L. (1999) Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial. Equine vet. J., Suppl. 29, 77-80.
12. Merritt, A.M., Sanchez, L.C., Burrow, J.A., Church, M. and Ludzia, S. (2003) Effect of GastroGard and three compounded oral omeprazole preparations on 24 h intragastric pH in gastrically cannulated mature horses. Equine vet. J. 35, 691-695.
13. Murray, M.J. (1989) Endoscopic appearance of gastric lesions in foals: 94 cases (1987-1988). J. Am. vet. med. Ass. 195, 1135-1141.
14. Murray, M.J. (1991) The pathogenesis and prevalence of gastric ulceration in foals and horses. Vet. Med. 86, 819.
15. Murray, M.J. (1999) Gastroduodenal ulceration in foals. Equine vet. Educ. 1, 43-52.
16. Murray, M.J. and Schusser, G.F. (1993) Measurement of 24-hour gastric pH using an indwelling pH electrode in horses unfed, fed and treated with ranitidine. Equine vet. J. 25, 417-421.
17. Murray, M.J., Haven, M.L., Eichorn, E.S., Zhang, D., Eagleson, J. and Hickey, G.J. (1997) Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses. Equine vet. J. 29, 425-429.
18. Murray, M.J., Eichorn, E.S., Holste, J.E., Cox, J.L., Stanier, W.B., Cooper, W.L. and Cooper, V.A. (1999) Safety, acceptability and endoscopic findings in foals and yearling horses treated with a paste formulation of omeprazole for twenty-eight days. Equine vet. J., Suppl. 29, 67-70.
19. Pue, M.A., Laroche, J., Meineke, I. and de Mey, C. (1993) Pharmacokinetics of pantoprazole following single intravenous and oral administration to healthy male subjects. Eur. J. Clin. Pharmacol. 44, 575-578.
20. Salas, M., Ward, A. and Caro, J. (2002) Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials. BMC Gastroenterol. 2, 17.
21. Sanchez, L.C., Lester, G.D. and Merritt, A.M. (1998) Effect of ranitidine on intragastric pH in clinically normal neonatal foals. J. Am. vet. med. Ass. 212, 1407-1412.
22. Sanchez, L.C., Lester, G.D. and Merritt, A.M. (2001) Intragastric pH in critically ill neonatal foals and the effect of ranitidine. J. Am. vet. med. Aas. 218, 907-911.
23. Sanchez, L.C., Murray, M.J. and Merritt, A.M. (2004) Effect of omeprazole paste on intragastric pH in clinically normal neonatal foals. Am. J. vet. Res. 65, 1039-1041.
24. Sangiah, S., McAllister, C.C. and Amouzadeh, H.R. (1988) Effects of cimetidine and ranitidine on basal gastric pH, free and total acid contents in horses. Res. vet. Sci. 45, 291-295.
25. Tanaka, M. and Yamazaki, H. (1996) Direct determination of pantoprazole enantiomers in human serum by reversed-phase high-performance liquid chromatography using a cellulose-based chiral stationary phase and column-switching system as a sample cleanup procedure. Anal. Chem. 68, 1513-1516.
26. Tanaka, M., Yamazaki, H., Hakusui, H., Nakamichi, N. and Sekino, H. (1997) Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole - a preliminary study. Chirality 9, 17-21.
27. Wolfe, M.M. and Soil, A.H. (1988) The physiology of gastric acid secretion. N. Engl. J. Med. 319, 1707-1715.