Differential stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor in extensive and poor metabolizers of pantoprazole-A preliminary study

Chirality

Volumn 9, Issue 1, 1997, Pages 17-21

  Tanaka, M ^a   Yamazaki, H ^a   Hakusui, H ^a   Nakamichi, N ^b   Sekino, H ^c  

^a DAIICHI SANKYO CO   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Sekino Hospital   (Japan)

Author keywords

genetic polymorphism; human; pantoprazole; proton pump inhibitor; stereoselective pharmacokinetics

Indexed keywords

PANTOPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG HALF LIFE; DRUG METABOLISM; ENANTIOMER; ENTERIC COATED TABLET; GENETIC POLYMORPHISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; JAPAN; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADMINISTRATION, ORAL; BENZIMIDAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MALE; OMEPRAZOLE; POLYMORPHISM, GENETIC; PROTON PUMPS; STEREOISOMERISM; SULFOXIDES; TABLETS, ENTERIC-COATED;

EID: 0030937510     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:1<17::AID-CHIR4>3.0.CO;2-D     Document Type: Article

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