Ratio of lathosterol to campesterol in serum predicts the cholesterol-lowering effect of sitostanol-supplemented margarine

International Journal of Clinical Pharmacology and Therapeutics

Volumn 43, Issue 7, 2005, Pages 305-310

  Thuluva, S C ^a   Igel, M ^a   Giesa, U ^a   Lutjohann D ^a   Sudhop, T ^a   von Bergmann, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Campesterol; Cholesterol; Hypercholesterolemia; Lathosterol; Sitostanol; Sitosterol

Indexed keywords

CAMPESTEROL; CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LATHOSTEROL; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MARGARINE; SITOSTANOL;

ADULT; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG MECHANISM; FOOD COMPOSITION; HUMAN; HYPERCHOLESTEROLEMIA; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PREDICTION;

EID: 22144449633     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP43305     Document Type: Article

References (33)

1. Adult Treatment Panel III 2001 Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults. JAMA 285: 2486-2497
2. Berge KE, Tian H, Graf GA et al 2000 Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290: 1771-1775
3. Berge KE, von Bergmann K, Lütjohann D et al 2002 Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. J Lipid Res 43: 486-494
4. Bjorkhem I, Miettinen T, Reihner E, Ewerth S, Angelin B, Einarsson K 1987 Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res 28: 1137-1143
5. Friedewald WT, Levy RI, Fredrickson DS 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502
6. Grundy SM 2004 Atherosclerosis imaging and the future of lipid management. Circulation 110: 3509-3511
7. Gylling H, Miettinen TA 1994 Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester- margarine treatment. Diabetologia 37: 773-780
8. Gylling H, Puska P, Vartiainen E, Miettinen TA 1999 Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. J Lipid Res 40: 593-600
9. Hallikainen MA, Sarkkinen ES, Uusitupa MI 2000 Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J Nutr 130: 767-776
10. Hallikainen MA, Sarkkinen ES, Wester I, Uusitupa MI 2002 Short-term LDL cholesterol-lowering efficacy of plant stanol esters. BMC Cardiovasc Disord 2: 14
11. Heinemann T, Kullak Ublick GA, Pietruck B, von Bergmann K 1991 Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol 40 (Supplement 1): S59-S63
12. Heinemann T, Axtmann G, von Bergmann K 1993 Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 23: 827-831
13. Hubacek JA, Berge KE, Cohen JC, Hobbs HH 2001 Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia. Hum Mutat 18: 359-360
14. Igel M, Giesa U, Lütjohann D, von Bergmann K 2003 Comparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice. J Lipid Res 44: 533-538
15. Ikeda I, Sugano M 1998 Inhibition of cholesterol absorption by plant sterols for mass intervention. Curr Opin Lipidol 9: 527-531
16. Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R 2003 Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78: 965-978
17. Kempen HJ, Glatz JF, Gevers Leuven JA, van der Voort HA, Katan MB 1988 Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res 29: 1149-1155
18. Kesaniemi YA, Miettinen TA 1987 Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population. Eur J Clin Invest 17: 391-395
19. Lee MH, Lu K, Hazard S et al 2001 Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet 27: 79-83
20. Lichtenstein AH, Deckelbaum RJ 2001 AHA Science advisory. Stanol/sterol ester-containing foods and blood cholesterol levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation 103: 1177-1179
21. McNamara DJ, Kolb R, Parker TS et al 1987 Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity. J Clin Invest 79: 1729-1739
22. Miettinen TA, Tilvis RS, Kesaniemi YA 1990 Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131: 20-31
23. Miettinen TA, Vanhanen H 1994 Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein E phenotypes. Atherosclerosis 105: 217-226
24. Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E 1995 Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 333: 1308-1312
25. Miettinen TA, Gylling H 2002 Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. Atherosclerosis 164: 147-152
26. Moghadasian MH, Frohlich JJ 1999 Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am J Med 107: 588-594
27. Nguyen TT 1999 The cholesterol-lowering action of plant stanol esters. J Nutr 129: 2109-2112
28. Nguyen TT, Dale LC, von Bergmann K, Croghan IT 1999 Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. Mayo Clin Proc 74: 1198-1206
29. Pollak OJ 1953 Reduction of blood cholesterol in man. Circulation 7: 702-706
30. Sehayek E, Nath C, Heinemann T et al 1998 U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans. J Lipid Res 39: 2415-2422
31. Tilvis RS, Miettinen TA 1986 Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr 43: 92-97
32. Vanhanen HT, Blomqvist S, Ehnholm C et al. 1993 Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment. J Lipid Res 34: 1535-1544
33. Vanhanen HT 1994 Cholesterol malabsorption caused by sitostanol ester feeding and neomycin in pravastatin-treated hypercholesterolaemic patients. Eur J Clin Pharmacol 47: 169-176