Synthesis and biochemical properties of 6-bromoandrostenedione derivatives with a 2,2-dimethyl or 2-methyl group as aromatase inhibitors

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 11, 2004, Pages 1878-1882

  Numazawa, Mitsuteru ^a   Handa, Wakako ^a   Yamada, Keiko ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2,2 dimethyl steroid; 2 methyl 1,4 diene steroid; 6 bromoandrostenedione; Aromatase; Inactivation mechanism; Suicide substrate

Indexed keywords

2 METHYL 6ALPHA BROMOANDROSTA 1,4 DIENE 3,17 DIONE; 2 METHYLANDROSTA 1,4 DIENE 3,17 DIONE; 2,2 DIMETHYL 6ALPHA BROMOANDROST 4 ENE 3,17 DIONE; 2,2 DIMETHYL 6BETA BROMOANDROST 4 ENE 3,17 DIONE; 6BETA BROMOANDROSTENEDIONE; ANDROSTENEDIONE DERIVATIVE; AROMATASE INHIBITOR; UNCLASSIFIED DRUG; 6 BROMOANDROSTENEDIONE; 6-BROMOANDROSTENEDIONE; ANDROSTENEDIONE; DRUG DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MICROSOME; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; KINETICS; PLACENTA; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANDROSTENEDIONE; AROMATASE INHIBITORS; HUMANS; KINETICS; MICROSOMES; PLACENTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22044450345     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.1878     Document Type: Article

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