Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs

Steroids

Volumn 68, Issue 6, 2003, Pages 503-513

  Numazawa, Mitsuteru ^a   Watari, Yoko ^a   Yamada, Keiko ^a   Umemura, Nao ^a   Handa, Wakako ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

19 Oxygenation; 2,2 Dimethylandrostenedione; 2 Methylandrostenedione; Aromatase inhibition; Aromatization; Human placental microsomes

Indexed keywords

2 ALPHA METHYL 19 HYDROXYANDROST 4 ENE 3,17 DIONE; 2 ALPHA METHYLANDROST 4 ENE 3,17 DIONE; 2 ALPHA METHYLANDROST 4 ENE 3,17,19 TRIONE; 2 BETA METHYLANDROST 4 ENE 3,17 DIONE; 2 METHYLENEANDROST 4 ENE 3,17 DIONE; 2,2 DIMETHYL 19 HYDROXYANDROST 4 ENE 3,17 DIONE; 2,2 DIMETHYLANDROST 4 ENE 3,17 DIONE; 2,2 DIMETHYLANDROST 4 ENE 3,17,19 TRIONE; ANDROSTENEDIONE DERIVATIVE; AROMATASE; AROMATASE INHIBITOR; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CATALYSIS; CHEMICAL BOND; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; HORMONE SYNTHESIS; INFRARED SPECTROSCOPY; MOLECULAR PROBE; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; STEREOSPECIFICITY; THERMODYNAMICS;

EID: 0043169335     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(03)00089-8     Document Type: Article

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