A hybrid Bayesian adaptive design for dose response trials

Journal of Biopharmaceutical Statistics

Volumn 15, Issue 4, 2005, Pages 677-691

  Chang, Mark ^a   Chow, Shein Chung ^b  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Bayesian adaptive design; Continual reassessment method; Dose escalation; Response adaptive randomization; Utility adaptive

Indexed keywords

ADAPTIVE DESIGN; ARTICLE; BAYES THEOREM; CANCER CHEMOTHERAPY; CLINICAL TRIAL; COMPUTER SIMULATION; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG DOSE REGIMEN; HUMAN; MAXIMUM TOLERATED DOSE; METHODOLOGY; ONCOLOGY; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RANDOMIZATION; STATISTICAL MODEL; STATISTICAL PARAMETERS;

ALGORITHMS; ANTINEOPLASTIC AGENTS; BAYES THEOREM; CLINICAL TRIALS; CLINICAL TRIALS, PHASE I; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDPOINT DETERMINATION; LIKELIHOOD FUNCTIONS; MODELS, STATISTICAL; RANDOM ALLOCATION; RESEARCH DESIGN;

EID: 22044446489     PISSN: 10543406     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIP-200062288     Document Type: Article

References (9)

1. Babb, J. S., Rogatko, A. (2004). Bayesian methods for cancer phase I clinical trials. In Advances in Clinical Trial Biostatistics. Geller, N., ed. New York: Marcel Dekker, pp. 1-40.
2. Bauer, P., Rohmel, J. (1995). An adaptive method for establishing a dose-response relationship. Statist. Med. 14:1595-1607.
3. Crowley, J. (2001). Handbook of Statistics in Clinical Oncology. New York: Marcel Dekker.
4. EMEA (2002). Point to consider on methodological issues in confirmatory clinical trials with flexible design and analysis plan. The European Agency for the Evaluation of Medicinal Products Evaluation of Medicines for Human Use. CPMP/EWP/2459/02, London, UK.
5. Gasparini, M., Eisele, J. (2000). A curve-free method for phase I clinical trials. Biometrics 56:609-615.
6. O'Quigley, J., Pepe, M., Fisher, L. (1990). Continual reassessment method: A practical design for phase I clinical trial in cancer. Biometrics 46:33-48.
7. O'Quigley, J., Shen, L. (1996). Continual reassessment method: A likelihood approach. Biometrics 52:673-684.
8. Rosenberger, W., Lachin, J. (2003). Randomization in Clinical Trials. New York: John Wiley and Sons.
9. Whitehead, J. (1997). Bayesian decision procedures with application to dose-finding studies. International Journal of Pharmaceutical Medicine 11:201-208.