Severe hypoleptinaemia associated with insulin resistance in patients with common variable immunodeficiency

Clinical Endocrinology

Volumn 63, Issue 1, 2005, Pages 63-65

  Ferraroni, Natasha Rebouças ^a   Geloneze, Bruno ^a   Mansour, Eli ^a   Perroud, Ana Paula ^a   Muscelli, Elza O ^a   Tambascia, Marcos ^a   De Lima Zollner, Ricardo ^a   Velloso, Licio Augusto ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ADULT; AGE; ANALYSIS OF VARIANCE; ANTIBODY PRODUCTION; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HORMONE DEFICIENCY; HUMAN; HYPOLEPTINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECURRENT INFECTION; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

ADULT; BODY MASS INDEX; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; MIDDLE AGED;

EID: 22044444582     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2005.02300.x     Document Type: Article

References (12)

1. Moffitt, J.E., Guill, M.F., Leffell, M.S., Ades, E.W., Burek, C.L., Lobel, S.A. & Hoffman, W.H. (1989) Type I diabetes in an adolescent with common variable immunodeficiency. Journal of Allergy and Clinical Immunology, 84, 191-196.
2. Moschella, S.L., Rex, I. Jr & Goldman, G.C. (1971) Primary acquired hypogammaglobulinemia, diabetes mellitus, recurrent pyoderma, and obesity. Archives of Dermatology, 104, 452-454.
3. Kaplan, I.V. & Levinson, S.S. (1999) Misleading urinary protein pattern in a patient with hypogammaglobulinemia: effects of mechanical concentration of urine. Clinical Chemistry, 45, 417-419.
4. Savage, D.B. & O'Rahilly, S. (2002) Leptin: a novel therapeutic role in lipodystrophy. Journal of Clinical Investigation, 109, 1285-1286.
5. Carvalheira, J.B., Ribeiro, E.B., Folli, F., Velloso, L.A. & Saad, M.J. (2003) Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver. Biological Chemistry, 384, 151-159.
6. Cunningham-Rundles, C. (2001) Common variable immunodeficiency. Current Allergy and Asthma Reports, 1, 421-429.
7. Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F., Egger, G., Targher, G., Alberiche, M., Bonadonna, R.C. & Muggeo, M. (1998) Prevalence of insulin resistance in metabolic disorders: The Bruneck Study. Diabetes, 47, 1643-1649.
8. Ruige, J.B., Dekker, J.M., Blum, W.F., Stehouwer, C.D., Nijpels, G., Mooy, J., Kostense, P.J., Bouter, L.M. & Heine, R.J. (1999) Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study. Diabetes Care, 22, 1097-1104.
9. Raskin, S., Pereira, L., Reis, F., Rosario, N.A., Ludwig, N., Valentim, L., Phillips, J.A. 3rd, Allito, B., Heim, R.A., Sugarman, E.A., Probst, C., Faucz, F. & Culpi, L. (2003) High allelic heterogeneity between Afro-Brazilians and Euro-Brazilians impacts cystic fibrosis genetic testing. Genetics Testing, 7, 213-218.
10. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. & Turner, R.C. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
11. Farooqi, I.S., Matarese, G., Lord, G.M., Keogh, J.M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S.A., Perna, F., Fontana, S., Lechler, R.I., Depaoli, A.M. & O'Rahilly, S. (2002). Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Journal of Clinical Investigation, 110, 1093-1103.
12. Busso, N., So, A., Chobaz-Peclat, V., Morard, C., Martinez-Soria, E., Talabot-Ayer, D. & Gabay, C. (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. Journal of Immunology, 168, 875-882.