Raffinee in the treatment of spinal cord injury: An open-labeled clinical trial

Annals of the New York Academy of Sciences

Volumn 1042, Issue , 2005, Pages 396-402

  Chen, Hsin Ying ^a   Lin, Jer Min ^b   Chuang, Hung Yi ^c   Chiu, Wen Ta ^a,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TUNG FANG INSTITUTE OF TECHNOLOGY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Free radical scavenger; Lipid peroxidation; Raffinee; Spinal cord injury

Indexed keywords

NATURAL PRODUCT; RAFFINEE; SCAVENGER; UNCLASSIFIED DRUG;

ADULT; AGED; CLINICAL ARTICLE; CONFERENCE PAPER; DAILY LIFE ACTIVITY; DIARRHEA; FEMALE; HUMAN; INSOMNIA; LIPID PEROXIDATION; MALE; MOTOR ACTIVITY; SPINAL CORD INJURY; TAIWAN; WILCOXON SIGNED RANKS TEST;

EID: 22044436553     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1338.062     Document Type: Conference Paper

References (25)

1. TATOR, C.H. 1983. Spine-spinal cord relationships in spinal cord trauma. Clin. Neurosurg. 30: 479-494.
2. KAKULAS, B.A. 1984. Pathology of spinal injuries. Cent. Nerv. Syst. Trauma 1: 117-129.
3. TATOR, C.H. & M.G. FEHLINGS. 1991. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanism. J. Neurosurg. 75: 15-26.
4. SIESJO, B.K. 1992. Pathophysiology and treatment of focal cerebral ischemia. Part I: pathophysiology. J. Neurosurg. 77: 169-184.
5. SIESJO, B.K. 1992. Pathophysiology and treatment of focal cerebral ischemia. Part II: mechanisms of damage and treatment. J. Neurosurg. 77: 337-354.
6. PETTY, M.A., P. POULET, A. HAAS, et al. 1996. Reduction of traumatic brain edema by a free radical scavenger. Eur. J. Pharmacol. 307: 149-155.
7. GUHA, A., C.H. TATOR & J. ROCHON. 1989. Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 20: 372-377.
8. FADEN, A.L. & R.P. SIMON. 1988. A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann. Neurol. 23: 623-626.
9. GUTTERIDGE, J.M. 1995. Hydroxyl radicals, iron, oxidative stress, and neurodegeneration. Ann. N.Y. Acad. Sci. 765: 201-213.
10. PARK, E., Y. LIU & M.G. FEHLINGS. 2003. Changes in glial cell white matter AMPA receptor expression after spinal cord injury and relationship to apoptotic cell death. Exp. Neurol. 182: 35-48.
11. BRACKEN, M.B., M.J. SHEPARD, W.F. COLLINS, et al. 1990. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N. Engl. J. Med. 322: 1405-1411.
12. BRACKEN, M.B., M.J. SHEPARD, T.R. HOLFORD, et al. 1997. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury: results of the third national acute spinal cord injury randomized controlled trial. JAMA 277: 1597-1604.
13. NAITO, M. et al. 2003. Anti-atherogenic effects of fermented fresh coffee bean, soybean and rice bran extracts. Food Sci. Technol. Res. 9: 170-175.
14. CHEN, H.Y., J.M. LIN & C.C. LIN. 1998. "Raffinee," a free radical scavenger, in the treatment of subacute stage brain and spinal cord lesions: a case report. Am. J. Chin. Med. XXVI: 98-103.
15. AMERICAN SPINAL INJURY ASSOCIATION. 1996. International Standards for Neurological and Functional Classification of Spinal Cord Injury. ASIA. Chicago.
16. SEGAL, A.W. & O.T. JONES. 1980. Absence of cytochrome b reduction in stimulated neutrophils from both female and male patients with chronic granulomatous disease. FEBS Lett. 110: 111-114.
17. YUKIE, N., S. TSUYOSHI, M. YOSHIKI & O. MOTOAKI. 1984. Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous Superoxide dismutase activity and hydroxyl radical generation by clofazimine. J. Clin. Microbiol. 20: 837-842.
18. MAHONEY, F.I. & D.W. BARTHEL. 1965. Functional evaluation: the Barthel Index. Md. State Med. J. 14: 61-65.
19. HARRISON, W.W., M.G. NETSKY & M.D. BROWN. 1968. Trace elements in human brain: copper, zinc, iron and magnesium. Clin. Chim. Acta 21: 55-60.
20. STOCKS, J., J.M. GUTTERIDGE, R.J. SHARP & T.L. DORMANDY. 1974. Assay using brain homogenate for measuring the antioxidant activity of biological fluids. Clin. Sci. Mol. Med. 47: 215-222.
21. GUTTERIDGE, J.M. 1992. Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage. Clin. Sci. 82: 315-320.
22. CHOI, D.W. 1990. Cerebral hypoxia: some new approaches and unanswered questions. J. Neurosci. 10:2493-2501.
23. LIPTON, S.A., Y.B. CHOI, C.H. PAN, et al. 1993. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364: 626-632.
24. .) initiated lipid peroxidation. J. Biol. Chem. 266: 15091-15098.
25. YOUNG, W. 1993. Secondary injury mechanism in acute spinal cord injury. J. Emerg. Med. 11: 13-22.