DNA-damage during photo(chemo)therapy studied by comet-assay

Neoplasma

Volumn 46, Issue SUPPL. 1, 1999, Pages 106-107

  Emri, G ^a   Remenyik, E ^a   Varga, Cs ^a   Hunyadi, J ^a   Horkay, I ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Neutral comet assay; UV and PUVA induced DNA strand breaks

Indexed keywords

EID: 21944455834     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. AVERBECK, D., DARDALHON, M., MAGANA-SCHWENCKE, N., MEIRA, L.B., MENIEL, V, BOITEUX, S., SAGE, E.: New aspects of the repair and genotoxicity of psoralen photoinduced lesions in DNA. J. Photochem. Photobiol. B:Biol., 14, 1992, 47-63.
2. BETHEA, D., FULLMER, B., SYED, S., SELTZER, G., TIANO, J., RISCHKO, C., GILLESPIE, L., BROWN, D., GASPARRO F.P.: Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J. Dermatol. Science, 19, 1999, 78-88.
3. COVEN, T.R., WALTERS, I.B., CARDINALE, I., KRUECER, J.G.: PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis. Photoderm. Photoimm. Photomed., 15, 1999, 22-27.
4. EL-MOFTY, A.M.: A preliminary clinical report on the treatment of leukoderma with Ammi majus Linn. J. R. Egypt. M. A., 31, 1948, 651.
5. GASPARRO, F.P.: Psoralen DNA photobiology. CRC Press, 1988, Inc. Boca Raton, Florida.
6. LEHMANN, J., POLLET, D., PEKER, S., STEINKRAUS, V, HOPFE, U.: Kinetics of DNA strand breaks and protection by antioxidants in UVA- orUVB-irradiated HaCaT keratinocytes using the single cell gel electrophoresis assay. Mutat. Res., 407, 1998, 97-108.
7. ORTEL, B., GANGE, R.W.: An action spectrum for the elicitation of erythema in skin persistently sensitized by photobound 8-methoxypsoralen. J. Invest. Dermatol., 94, 1990, 781-785.
8. PFUHLER, S., WOLF, H.U.: Detection of DNA-crosslinking agents with the alkaline comet assay. Environ. Mol. Mutagen., 27, 1996, 196-201.
9. SCHOTHORST, A. A., EVERS L. M., Noz K.C., FILON R., VAN ZEELAND A.A.: Pyrimidine dimer induction and repair in cultured human skin keratinocytes or melanocytes after irradiation with monochromatic ultraviolet radiation. J. Invest. Dermatol., 96, 1991, 916-920.
10. SINGH, N.P., McCOY, M.T., TICE, R.R., SCHNEIDER, E.L.: A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell. Res., 175, 1988, 184-191.
11. STERN, R.S., LAIRD, N.: The carcinogenic risk of treatments for severe psoriasis. Cancer, 73, 1994, 2759-2764.
12. VAN HOUTEN, B., CAMPER, H., HOLBROOK, S.R., HEARST, J.E., SANCAR, A.: Action mechanism of ABC excision nuclease on a DNA substrate containing a psoralen crosslink at a defined position. Proc. Natl. Acad. Sci. USA, 83, 1986, 8077-8081.
13. VARGA, Cs., HORVÁTH, G., TIMBRELL, V: On the mechanism of cogenotoxic action between ingested amphibole asbestos fibres and benzo(a)pyrene: II. Tissue specificity studies using comet assay. Cancer Letters, 1999 (in press).