Phosphatidylserine/phosphatidylcholine microvesicles can induce preeclampsia-like changes in pregnant mice

Seminars in Thrombosis and Hemostasis

Volumn 31, Issue 3, 2005, Pages 314-320

  Omatsu, Kohei ^b   Kobayashi, Takao ^a   Murakami, Yusuke ^b   Suzuki, Mika ^b   Ohashi, Ryota ^b   Sugimura, Motoi ^b   Kanayama, Naohiro ^b  

^a SHINSHU UNIVERSITY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hypercoagulation; Hypertension; Intrauterine growth restriction; Phosphatidylserine (PS) phosphatidylcholine (PC); Preeclampsia

Indexed keywords

ANTITHROMBIN; ETHER; FIBRIN; PARAFORMALDEHYDE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; SODIUM CHLORIDE; THROMBIN ANTITHROMBIN COMPLEX;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FETUS; FETUS WEIGHT; FIBRIN DEPOSITION; HEART; HISTOPATHOLOGY; HYPERCOAGULABILITY; HYPERTENSION; INTRAUTERINE GROWTH RETARDATION; MOUSE; NONHUMAN; PLACENTA; PLACENTA WEIGHT; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEINURIA; STATISTICAL ANALYSIS; SYSTOLIC BLOOD PRESSURE; TAIL; THROMBOCYTE COUNT;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; FETAL WEIGHT; INJECTIONS; LIPOSOMES; MICE; MICE, INBRED ICR; ORGAN SIZE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; THROMBOPHILIA;

EID: 21844478086     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-872438     Document Type: Article

References (32)

1. Mushambi MC, Halligan AW, Williamson K. Recent developments in the pathophysiology and management of pre-eclampsia. Br J Anaesth 1996;76:133-138
2. Khatun S, Kanayama N, Belayet H, et al. The impact of vasoactive peptides on nitric oxide production in cultured sympathetic neurons. Neuroscience 1999;93:605-609
3. Khatun S, Kanayama N, Belayet H, et al. Increased concentrations of plasma neuropeptide-Y in patients with eclampsia and preeclampsia. Am J Obstet Gynecol 2000;182: 896-900
4. Kobayashi T, Terao T. Preeclampsia as chronic disseminated intravascular coagulation. Gynecol Obstet Invest 1987;24: 170-178
5. Kobayashi T, Tokunaga N, Sugimura M, et al. Coagulation/ fibrinolysis disorder in patients with severe preeclampsia. Semin Thromb Hemost 1999;25:451-454
6. Kobayashi T, Tokunaga N, Sugimura M, Kanayama N, Terao T. Predictive values of coagulation/fibrinolysis parameters for the termination of pregnancy complicated by severe preeclampsia. Semin Thromb Hemost 2001;27:137-141
7. Kobayashi T, Sumimoto K, Tokunaga N, et al. Coagulation index to distinguish severe preeclampsia from normal pregnancy. Semin Thromb Hemost 2002;28:495-499
8. Kobayashi T, Tokunaga N, Sugimura M, Kanayama N, Terao T. Vasospasms are characteristic in cases with eclampsia/ preeclampsia and HELLP syndrome: proposal of angiospastic syndrome of pregnancy. Semin Thromb Hemost 2001;27: 131-135
9. Kelton JG, Hunter DJS, Neame PB. A platelet function defect in pre-eclampsia. Obstet Gynecol 1985;65:107-109
10. Norris LA, Bevers EM, Comfurius P, van Rijn JLML, Hemke HC, Zwaal RFA. Generation of prothrombin-converting activity and the exposure of phosphatidylserine on the outer surface of platelets. Eur J Biochem 1982;122: 429-437
11. Vogt E, Ng AK, Rote NS. A model for the antiphospholipid antibody syndrome: monoclonal antiphosphatidylserine antibody induces intrauterine growth restriction in mice. Am J Obstet Gynecol 1996;174:700-707
12. Sugimura M, Su F, Kanayama N, Kobayashi H, Kobayashi T, Terao T. Anticoagulant activity in non-immunoglobulin fraction from plasma of patients with antiphospholipid syndrome. Semin Thromb Hemost 1998;24:473-477
13. Miyazaki Y, Nomura S, Miyake T, et al. High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles. Blood 1996;88:3456-3464
14. Abdul Halim MB, Kanayama N, Maradny EE, et al. Plasma P selectin (GMP-140) and glycocalicin are elevated in preeclampsia and eclampsia: their significance. Am J Obstet Gynecol 1996;174:272-277
15. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982;142:159-167
16. Kobayashi T, Sugimura M, Naruse H, et al. Anticholinergics induce eclamptic seizures. Semin Thromb Hemost 2002;28: 511-514
17. Thiagarajan P, Tait JF. Collagen-induced exposure of anionic phospholipid in platelets and platelet-derived microparticles. J Biol Chem 1991;266:24302-24307
18. Chap HJ, Zwaa RFA, van Deenen LLM. Action of highly purified phospholipids on blood platelets. Evidence for an asymmetric distribution of phospholipids in the surface membrane. Biochim Biophys Acta 1977;467:146-164
19. Bevers EM, Comfurius P, van Rijn JLML, Hemker HC, Zwaal RFA. Generation of prothrombin-converting activity and the exposure of phosphatidylserine on the outer surface of platelets. Eur J Biochem 1982;122:429-437
20. Stuart MC, Bevers EM, Comfurius P, Zwaal RF, Reutelingsperger CP, Frederik PM. Ultrastructural detection of surface exposed phosphatidylserine on activated blood platelets. Thromb Haemost 1995;74:1145-1151
21. Rosing J, Tans G, Govers-Reimslag WP, Zwaal RFA, Hemker HC. The role of phospholipid and factor Va in the prothrombinase complex. J Biol Chem 1980;255:274-283
22. Kumar R, Béguin S, Hemker HC. The effect of fibrin clots and clot-bound thrombin on the development of platelet procoagulant activity. Thromb Haemost 1995;74:962-968
23. Kinlough-Rathbone RL, Perry DW. Prolonged expression of procoagulant activity of human platelets degranulated by thrombin. Thromb Haemost 1995;74:958-961
24. Siljander P, Carpen O, Lassila R. Platelet-derived microparticles associated with fibrin during thrombosis. Blood 1996;87:4651-4663
25. Sugimura M, Kobayashi T, Shu F, Kanayama N, Terao T. Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice. Placenta 1999;20:555-560
26. Shu F, Sugimura M, Kanayama N, Kobayashi H, Kobayashi T, Terao T. Immunohistochemical study of annexin V expression in placentae of preeclampsia. Gynecol Obstet Invest 2000;49:17-23
27. Sugimura M, Ohashi R, Kobayashi T, Kanayama N. Intraplacental coagulation in intrauterine growth restriction: cause or result? Semin Thromb Hemost 2001;27:107-113
28. Perry KG, Martin JN. Abnormal hemostasis and coagulopathy in preeclampsia and eclampsia. Clin Obstet Gynecol 1992;35:338-350
29. Rabiet MJ, Plantier JL, Dejana E. Thrombin induced endothelial cell dysfunction. Br Med Bull 1994;50:936-945
30. Maki M, Kobayashi T, Terao T, et al. Antithrombin therapy for severe preeclampsia: results of a double blind, randomized, placebo-controlled trial. Thromb Haemost 2000;84:583-590
31. Kobayashi T, Terao T, Ikenoue T, Kajiwara Y, Maki M. Antithrombin therapy for preeclampsia. Biomed Progress 2003;16:72-77
32. Kobayashi T, Terao T, Ikenoue T, et al. Treatment of severe preeclampsia with antithrombin concentrate: results of a prospective feasibility study. Semin Thromb Hemost 2003;29: 645-652