Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy

Epilepsia

Volumn 46, Issue SUPPL. 5, 2005, Pages 49-51

  Arbatova, Jelena ^a   D'Amato, Elena ^b,c   Vaarmann, Annika ^d   Zharkovsky, Alex ^d   Reeben, Mati ^e  

^a Glenlab Niini Ltd   (Finland)

^b UNIVERSITY OF GENOA   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF TARTU   (Estonia)

^e UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cystatin B deficient mice; Kynurenines; Progressive myoclonus epilepsy; Serotonin; Tryptophan

Indexed keywords

3 HYDROXYANTHRANILIC ACID; CYSTATIN B; KYNURENINE; SEROTONIN; TRYPTOPHAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CASE REPORT; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE COURSE; ELECTROCHEMICAL ANALYSIS; EVALUATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; MOUSE; MYOCLONUS EPILEPSY; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEROTONIN BLOOD LEVEL; SEROTONIN RELEASE; TRYPTOPHAN METABOLISM;

3-HYDROXYANTHRANILIC ACID; ADULT; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTATINS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; KYNURENINE; MALE; MICE; MYOCLONIC EPILEPSIES, PROGRESSIVE; SEROTONIN; TRYPTOPHAN;

EID: 21844476742     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2005.01008.x     Document Type: Conference Paper

References (15)

1. Pennacchio LA, Lehesjoki A-E, Stone NE, et al. Mutations in the gene encoding cystatin B cause progressive myoclonus epilepsy (EPM1). Science 1996;271:1731-4.
2. Leino E, MacDonald E, Airaksinen MM, Riekkinen PJ. Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with progressive myoclonus epilepsy. Acta Neurol Scand 1980;62:41-54.
3. Airaksinen EM, Leino E. Decrease of GABA in the cerebrospinal fluid of patients with progressive myoclonus epilepsy and its correlation with the decrease of 5HIAA and HVA. Acta Neurol Scand 1982;66:666-72.
4. Koskiniemi M, Hyyppa M, Sainio K, Salmi T, Sama S, Uotila L. Transient effect of L-tryptophan in progressive myoclonus epilepsy without Lafora bodies: clinical and electrophysiological study. Epilepsia 1980;21:351-7.
5. Leino E, MacDonald E, Airaksinen MM, Riekkinen PJ, Salo H. L-tryptophan-carbidopa trial in patients with long-standing progressive myoclonus epilepsy. Acta Neurol Scand 1981;64:132-41.
6. Pranzatelli MR, Tate E, Huang Y, et al. Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan. Epilepsia 1995;36:783-91.
7. Stone TW. Endogenous neurotoxins from tryptophan. Toxicon 2001;39:61-73.
8. Schwarcz R. The kynurenine pathway of tryptophan degradation as a drug target. Curr Opin Pharmacol 2004;4:12-7.
9. Pratt JA, Jenner P, Johnson AL, Shorvon SD, Reynolds EH. Anti-convulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function. J Neurol Neurosurg Psychiatry 1984;4:1131-3.
10. Koskiniemi M. Findings in routine laboratory examination in progressive myoclonus epilepsy. Acta Neurol Scand 1975;51:12-20.
11. Pennacchio LA, Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RM. Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Nature Genet 1998;20:251-8.
12. Vaarmann A, Kask A, Mäeorg U. Novel and sensitive high-performance liquid chromatographic method based on electrochemical coulometric array detection for simultaneous determination of catecholamines, kynurenine and indole derivatives of tryptophan. J Chromatography B Analyt Technol Biomed Life Sci 2002;769:145-53.
13. Koskiniemi ML. Deficient intestinal absorption of L-tryptophan in progressive myoclonus epilepsy without Lafora bodies. J Neurol Sci 1980;47:1-6.
14. Hiraoka A, Miura I, Sato M, Tominaga I, Hattori M. Effects of anti-epileptic drugs on the L-tryptophan binding to human serum albumin. Chem Pharm Bull (Tokyo) 1992;40:1629-30.
15. Lapin IP. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm 1978;42:37-43.