Nitric oxide and prostaglandin E2 synthesis inhibitory activities of diarylheptanoids from the barks of Alnus japonica steudel

Archives of Pharmacal Research

Volumn 28, Issue 2, 2005, Pages 177-179

  Kim, Hyun Jung ^a   Yeom, Seung Hwan ^a   Kim, Min Kee ^a   Shim, Jae Geul ^a   Paek, In Na ^a   Lee, Min Won ^a  

^a Chung Ang University   (South Korea)

Author keywords

Alnus japonica; Anti inflammation; Betulaceae; Cancer chemoprevention; Cyclooxygenase 2; Diarylheptanoid; Nitric oxide

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GAMMA INTERFERON; HEPTANE DERIVATIVE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ALDER; ARTICLE; BARK; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MACROPHAGE; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ALNUS; CHROMATOGRAPHY, THIN LAYER; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DIARYLHEPTANOIDS; DINOPROSTONE; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT BARK; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES;

EID: 21844447165     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977711     Document Type: Article

References (9)

1. Jang D. S., Muriel C., Alison D. P., Leonardus B. S. K., Kazuko K., Norman R. F., Harry H. S. F., John M. P., and A. Douglas K., Potential cancer chemopreventive constituents of the leaves of Macaranga triloba. Phytochemistry, 65, 345-350 (2004)
2. Je K. H., Jan A. R., Lee H. T., Mar W. C., and Seo E. K., The inhibitory Principle of lipopolysaccharide-Induced Nitric Oxide Production from Inula britannica var. chinensis. Arch. Pharm. Res., 27, 83-85 (2004).
3. Kim, H. J., Kim, K. H., Yeom, S. H., Kim, M. K., Shim, J. G., and Lee M. W., New Diarylheptanoid from the Barks of Alnus japonica steudel. Chinese Chem. Lett., submitted (2004).
4. Lee, M. W., Kim N. Y., Park. M. S., Ahn, K. H., Toh, S. H., Hahn, D. R., Kim, Y. C., and Chung, J. T., Diarylheptanoids with In vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta. Planta Med., 66, 551-553 (2000).
5. Lee, M. W., Kim J. H., Jeong, D. W., Ahn, K. H., Toh, S. H., and Surh, Y. J., Inhibition of Cyclooxygenase-2 Expression by Diarylheptanoids from the Bark of Alnus hirsuta var. sibirica. Biol. Pharm. Bull., 23, 517-518 (2000).
6. Moncada S., Palmer R. M., and Higgs E. A., Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 1091-1042 (1991).
7. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Iimmunol. Methods., 65, 55-63 (1983).
8. Rie I., Koichi S., Masakazu H., Takeshi S., Susumu K., and Fumio A., Inhibitory Effects of Hydrolyzable Tannins from Melastoma dodecandrum Lour. On Nitric Oxide Production by a Murine Macrophage-Like cell Line, RAW 264.7, Activated with Lipopolysaccharide and Interferon-γ. Biol. Pharm. Bull., 22, 647-653 (1999)
9. Subbaramiah K., Telang N., Ramonetti J. T., Araki T., DeVito B., Weksler B. B., and Dannenberg A. J., Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res., 56, 4424-4429 (1996).