Pravastatin does not have a consistent antiviral effect in chronically HIV-infected individuals on antiretroviral therapy [1]

AIDS

Volumn 19, Issue 10, 2005, Pages 1109-1111

  Sklar, Peter A ^a,b   Masur, Henry ^b   Grubb, Jessica R ^c   Voell, Jocelyn ^c   Witek, James ^a   Ono, Akira ^d   Freed, Eric O ^d   Maldarelli, Frank ^d  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPRENAVIR; CHOLESTEROL; DELAVIRDINE; DIDANOSINE; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; PRAVASTATIN; RITONAVIR; RNA; STAVUDINE; TENOFOVIR; ZIDOVUDINE;

ADULT; ANTIVIRAL ACTIVITY; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; MALE; PRIORITY JOURNAL; REBOUND; T LYMPHOCYTE; VIREMIA; VIRUS LOAD;

EID: 21844446908     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.aids.0000174461.31794.50     Document Type: Letter

References (8)

1. Freed EO. HIV-1 gag proteins: diverse functions in the virus life cycle. Virology 1998; 251:1-15.
2. Nguyen DH, Hildreth JE. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol 2000; 74:3264-3272.
3. Manes S, Del Real G, Lacalle RA, Lucas P, Gomez-Mouton C, Sanchez-Palomino S, et al. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep 2000; 1:190-196.
4. Liao Z, Cimakasky LM, Hampton R, Nguyen DH, Hildreth JE. Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1. AIDS Res Hum Retroviruses 2001; 17:1009-1019.
5. Viard M, Parolini I, Sargiacomo M, Fecchi K, Ramoni C, Ablan S, et al. Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells. J Virol 2002; 76:11584-11595.
6. Ono A, Freed EO. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci USA 2001; 98:13925-13930.
7. Del Real G, Jimenez-Baranda S, Mira E, Lacalle RA, Lucas P, Gomez-Mouton C, et al. Statins inhibit HIV-1 infection by down-regulating rho activity. J Exp Med 2004; 200:541-547.
8. Fichtenbaum CJ, Gerber JG, Rosenkranz SL, Segal Y, Aberg JA, Blaschke T, et al. Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047. AIDS 2002; 16:569-577.