Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis

Biochemistry

Volumn 44, Issue 25, 2005, Pages 9013-9021

  Siddiqi, Ferhan ^a   Bourque, Jennifer R ^a   Jiang, Haiyan ^b   Gardner, Marieke ^a   St Maurice, Martin ^a   Blouin, Christian ^a,b   Bearne, Stephen L ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; COMPUTER SIMULATION; CRYSTAL STRUCTURE; ENZYMES; GROUND STATE; HYDROPHOBICITY; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; MUTAGENESIS; PERTURBATION TECHNIQUES; PROTONS; SUBSTRATES; YEAST;

HYDROPHOBIC ACTIVITY; LIGANDS; MANDELATE RACEMASE; PSEUDOMONAS PUTIDA;

ENZYME KINETICS;

BENZILIC ACID; CYCLOHEXYLPHENYLGLYCOLIC ACID; GLYCOLIC ACID; MANDELATE RACEMASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; PSEUDOMONAS PUTIDA; RACEMIZATION; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; WILD TYPE;

BINDING SITES; CATALYSIS; COMPUTER SIMULATION; HYDROPHOBICITY; HYDROXYBUTYRATES; ISOMERISM; KINETICS; MANDELIC ACIDS; MODELS, MOLECULAR; MOVEMENT; MUTATION; PHENOL; PHENYLALANINE; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS PUTIDA; RACEMASES AND EPIMERASES;

PSEUDOMONAS PUTIDA;

EID: 21744454185     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0473096     Document Type: Article

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